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36 results on '"Khoury, Jane"'

1. Prepregnancy BMI, gestational weight gain, and susceptibility to autism‐related traits: the EARLI and HOME studies

Author

Patti, Marisa A., primary, Croen, Lisa A., additional, Chen, Aimin, additional, Fallin, M. Daniele, additional, Khoury, Jane, additional, Lyall, Kristen, additional, Newschaffer, Craig, additional, Hertz‐Picciotto, Irva, additional, Schmidt, Rebecca J., additional, Yolton, Kimberly, additional, and Braun, Joseph M., additional

Published
2023
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2. A 3‐Min Recumbent Stepper Test in Chronic Stroke

Author

Carl, Daniel, primary, Whitesel, Dustyn, additional, Meyrose, Colleen, additional, Westover, Jennifer, additional, Khoury, Jane, additional, Gerson, Myron, additional, Kissela, Brett, additional, Dunning, Kari, additional, and Boyne, Pierce, additional

Published
2022
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8. Sex differences in cardiovascular risk profiles of ischemic stroke patients with diabetes in the Greater Cincinnati/Northern Kentucky Stroke Study

Author

Madsen, Tracy E., primary, Khoury, Jane C., additional, Alwell, Kathleen A., additional, Moomaw, Charles J., additional, Demel, Stacie L., additional, Flaherty, Matthew L., additional, Woo, Daniel, additional, Mackey, Jason, additional, De Los Rios La Rosa, Felipe, additional, Martini, Sharyl, additional, Ferioli, Simona, additional, Adeoye, Opeolu, additional, Khatri, Pooja, additional, Kissela, Brett M., additional, and Kleindorfer, Dawn, additional

Published
2017
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10. Potentially Missed Diagnosis of Ischemic Stroke in the Emergency Department in the Greater Cincinnati/Northern Kentucky Stroke Study

Author

Madsen, Tracy E., primary, Khoury, Jane, additional, Cadena, Rhonda, additional, Adeoye, Opeolu, additional, Alwell, Kathleen A., additional, Moomaw, Charles J., additional, McDonough, Erin, additional, Flaherty, Matthew L., additional, Ferioli, Simona, additional, Woo, Daniel, additional, Khatri, Pooja, additional, Broderick, Joseph P., additional, Kissela, Brett M., additional, and Kleindorfer, Dawn, additional

Published
2016
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16. RNA in blood is altered prior to hemorrhagic transformation in ischemic stroke

Author

Jickling, Glen C., primary, Ander, Bradley P., additional, Stamova, Boryana, additional, Zhan, Xinhua, additional, Liu, Dazhi, additional, Rothstein, Lena, additional, Verro, Piero, additional, Khoury, Jane, additional, Jauch, Edward C., additional, Pancioli, Arthur M., additional, Broderick, Joseph P., additional, and Sharp, Frank R., additional

Published
2013
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21. Signatures of cardioembolic and large-vessel ischemic stroke

Author

Jickling, Glen C., primary, Xu, Huichun, additional, Stamova, Boryana, additional, Ander, Bradley P., additional, Zhan, Xinhua, additional, Tian, Yingfang, additional, Liu, Dazhi, additional, Turner, Renée J., additional, Mesias, Matthew, additional, Verro, Piero, additional, Khoury, Jane, additional, Jauch, Edward C., additional, Pancioli, Arthur, additional, Broderick, Joseph P., additional, and Sharp, Frank R., additional

Published
2010
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33. A 3-minute recumbent stepper test in chronic stroke.

Author

Carl DL, Whitesel D, Meyrose C, Westover J, Khoury J, Gerson M, Kissela B, Dunning K, and Boyne P

Subjects
Humans, Male, Blood Pressure, Heart Rate physiology, Oxygen Consumption physiology, Vital Signs, Female, Middle Aged, Aged, Exercise Test methods, Stroke diagnosis
Abstract

Background: Persons with stroke often have difficulty achieving target heart rate (HR) during graded exercise testing (GXT), which is known to limit test sensitivity for detecting clinically relevant cardiac conditions. A novel Recumbent Stepper 3-minute (RS 3Min) "all out" test may increase sensitivity of stress testing after stroke., Objective: To determine the feasibility of adding the RS 3Min test after GXT among persons after stroke., Design: A within-participant, nonrandomized, repeated measures design., Setting: Rehabilitation research laboratory and cardiovascular stress laboratory PARTICIPANTS: Fifteen participants with chronic stroke (56.7 ± 9.6 years; 6.4 ± 4.3 years post stroke; 8 male)., Interventions: All participants randomly completed (1) a symptom-limited treadmill GXT and (2) a symptom-limited RS GXT followed by RS 3Min critical power test., Main Outcome Measures: HR, ratings of perceived exertion, oxygen consumption, respiratory exchange ratio, and power output measured continuously during each test. Blood pressure measured every 2 minutes and or immediately post exercise. P value set at p < .05 from omnibus test for a significant difference among protocols., Results: The RS 3Min test had a significantly higher rate of achieving target HR compared to the RS GXT (9/14 vs 4/14, p = .02) and was not significantly different from the treadmill GXT (9/14 vs 5/14, p = .09). Minimum power output during the RS 3Min was significantly higher than peak power output during the RS GXT (110 ± 41 W vs. 84 ± 22 W, p = .02) with 12/15 participants reaching a VO 2 plateau., Conclusions: Although additional studies with randomized designs are needed, a novel RS 3Min "all out" test appears to be a promising method for enhancing test sensitivity in cardiovascular screening after stroke, while providing a potentially valid measure of critical power., (© 2022 The Authors. PM&R published by Wiley Periodicals LLC on behalf of American Academy of Physical Medicine and Rehabilitation.)

Published
2023
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34. Early exposure to flame retardants is prospectively associated with anxiety symptoms in adolescents: A prospective birth cohort study.

Author

Strawn JR, Xu Y, Cecil KM, Khoury J, Altaye M, Braun JM, Lanphear BP, Sjodin A, Chen A, and Yolton K

Subjects
Pregnancy, Child, Female, Adolescent, Humans, Cohort Studies, Maternal Exposure adverse effects, Prospective Studies, Birth Cohort, Anxiety epidemiology, Flame Retardants adverse effects
Abstract

Background: Anxiety disorders emerge during childhood and adolescence and are frequently preceded by subsyndromal anxiety symptoms. Environmental toxicants, including gestational polybrominated diphenyl ether (PBDE) exposure, are associated with neuropsychiatric sequelae; however, the role of PBDEs as risk factors for anxiety in adolescence is unclear., Methods: Using data from the Health Outcomes and Measures of the Environment (HOME) Study, a prospective pregnancy and birth cohort enrolled from 2003 to 2006, we investigated the relationship between gestational serum PBDE concentrations and anxiety symptoms in adolescents (N = 236). We measured five PBDE congeners (PBDE-28, -47, -99, -100, and -153) at 16 ± 3 weeks of gestation and calculated their sum (∑PBDE). We assessed self-reported anxiety symptoms using the Screen for Child Anxiety Related Emotional Disorders (SCARED) and depressive symptoms using the Children's Depression Inventory (CDI-2) at age 12 years. We estimated the associations of maternal PBDE concentrations with child anxiety and depressive symptoms using multivariable linear regression and modified Poisson regression. Covariates included child sex, maternal race, maternal age at delivery, maternal marital status, maternal education, and household income at the 12-year study visit as well as maternal depressive and anxiety symptoms. Sensitivity analyses were performed to control for maternal lead and mercury at delivery., Results: After adjusting for predetermined covariates, each doubling in maternal PBDE concentrations was associated with increased SCARED scores (e.g., for ∑PBDE, SCARED total score, β = 1.6 95% confidence interval [CI]: 0.3-2.9, p = .019) and a nonsignificant increase in depressive symptoms (e.g., for CDI total score, β = .8, 95% CI: -0.2-1.8, p = .11)., Conclusions: Gestational serum PBDE concentrations just before mid-pregnancy and during a period of active cortical and limbic neurogenesis, synaptogenesis and myelogenesis may be a risk factor for developing anxiety symptoms in early adolescence., (© 2022 The Authors. Depression and Anxiety published by Wiley Periodicals LLC.)

Published
2022
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35. Clinical Trial of Vitamin D 2 vs D 3 Supplementation in Critically Ill Pediatric Burn Patients.

Author

Gottschlich MM, Mayes T, Khoury J, and Kagan RJ

Subjects
Adolescent, Biomarkers blood, Burns blood, Child, Child, Preschool, Cholecalciferol blood, Double-Blind Method, Ergocalciferols blood, Female, Humans, Infant, Male, Parathyroid Hormone blood, Prospective Studies, Treatment Outcome, Vitamin D Deficiency blood, Vitamin D Deficiency drug therapy, Vitamins administration & dosage, Vitamins blood, Burns drug therapy, Cholecalciferol administration & dosage, Critical Illness therapy, Dietary Supplements, Ergocalciferols administration & dosage
Abstract

Background: Hypovitaminosis D exists postburn. However, evidence-based guidelines for vitamin D repletion are unknown. This investigation examined differences between D 2 and D 3 supplementation on outcome in children with burn injuries., Methods: Fifty patients with total body surface area burn of 55.7% ± 2.6% and full-thickness injury of 40.8% ± 3.8% were enrolled, ranging in age from 0.7-18.4 years. All participants received multivitamin supplementation per standardized clinical protocol. In addition, 100 IU/kg D 2 , D 3 , or placebo was administered daily during hospitalization using a randomized, double-blinded study design. Assay of total 25-hydroxyvitamin D (D25), 1,25-dihydroxyvitamin D (D1,25), 25-hydroxyvitamin D 2 (25-OH-D 2 ), 25-hydroxyvitamin D 3 (25-OH-D 3 ), and parathyroid hormone (PTH) was performed at 4 preplanned time intervals (baseline, midpoint, discharge, and 1 year postburn). Differences in vitamin D status were compared over time and at each specific study interval., Results: There were no significant differences in serum vitamin D levels between groups, but >10% of patients had low D25 at discharge, and percent deficiency worsened by the 1-year follow up for the placebo (75%), D 2 (56%), and D 3 (25%) groups. There were no statistical differences in PTH or clinical outcomes between treatment groups, although vitamin D supplementation demonstrated nonsignificant but clinically relevant decreases in exogenous insulin requirements, sepsis, and scar formation., Conclusions: The high incidence of low serum D25 levels 1 year following serious thermal injury indicates prolonged compromise. Continued treatment with vitamin D 3 beyond the acute phase postburn is recommended to counteract the trajectory of abnormal serum levels and associated morbidity.

Published
2017
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36. Stool pattern changes in toddlers consuming a follow-on formula supplemented with polydextrose and galactooligosaccharides.

Author

Ribeiro TC, Costa-Ribeiro H Jr, Almeida PS, Pontes MV, Leite ME, Filadelfo LR, Khoury JC, Bean JA, Mitmesser SH, Vanderhoof JA, and Scalabrin DM

Subjects
Acute Disease, Animals, Child, Preschool, Constipation prevention & control, Double-Blind Method, Female, Glucans administration & dosage, Humans, Infant, Infant Formula chemistry, Male, Milk, Oligosaccharides administration & dosage, Proportional Hazards Models, Prospective Studies, Defecation drug effects, Diarrhea prevention & control, Glucans pharmacology, Infant Formula pharmacology, Oligosaccharides pharmacology, Prebiotics, Respiratory Tract Infections prevention & control
Abstract

Healthy 9- to 48-month-old children (n = 133) were randomized to receive a cow's-milk-based follow-on formula (control) or the same formula with polydextrose and galactooligosaccharides (PDX/GOS) for 108 days. Pediatricians assessed diarrheal disease, stool pattern, acute respiratory infection, systemic antibiotic use, and growth. The 2 groups had similar weight-for-length/height z score and similar odds of having diarrheal disease, acute respiratory infection, and systemic antibiotic use; however, PDX/GOS had greater odds of increased defecation than control (P ≤ 0.01). Addition of PDX and GOS to a follow-on formula was well tolerated and induced a pattern of more frequent and softer stools in toddlers.

Published
2012
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