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The microstructure–properties relations and strengthening mechanisms of additively manufactured 316L stainless steel are comprehensively investigated in this work. The orientation dependency and the strain hardening are studied by tensile testing of as-built specimens fabricated by laser-based powder bed fusion (LPBF) in different directions. The results are compared with those obtained for wrought material. The microstructure of the wrought and the LPBF materials are also comprehensively investigated. Equiaxed grains with random orientation and relatively uniform size (≈30 μm) are observed in the wrought material, where the LPBF samples show columnar grains inside as well as fine equiaxed grains in the bottom of the molten pool. A bimodal grain size distribution, higher values of geometrically necessary dislocations density (≈25–32%), and lower fractions of high-angle grain boundaries (≈24–28%) are observed in LPBF 316L. A significant yield strength and considerable ultimate strength improvement without remarkable elongation decrease are obtained for the LPBF tensile specimens, resulting in a high strength-elongation balance (up to 26 122 MPa%). Two-stage strain hardening is depicted in both wrought and LPBF samples. This is successfully predicted with two-stage Hollomon analysis. However, the LPBF samples illustrate lower strain hardening exponents in comparison with the wrought ones.

Colorectal cancer (CRC) is one of the common human malignancies. Discovery and identification of novel therapeutic target is imperative to improve the prognosis of CRC patients. As a member of the PIM family, PIM3 has been found to be overexpressed in a variety of cancerous tumors. In this study, we evaluated the expression of PIM3 in CRC tissues and analyzed the role of PIM3 in CRC. Our results showed that PIM3 expression was significantly higher in CRC tissues compared with adjacent noncancerous tissues. The PIM3 expression level was found to be correlated with advanced disease stage and lymph node metastasis. Moreover, PIM3 was found to be able to predict poor prognosis in CRC patients as an independent factor. In vitro studies also showed that knockdown of PIM3 exhibited inhibitory effect on cell growth, promoted cell apoptosis and dampened invasive capability of HCT116 and SW620 cells. Moreover, PIM3 knockdown was able to delay tumor growth and suppress lung metastasis in xenograft model. Our results indicated that PIM3 is a potential therapeutic target for CRC. Anat Rec, 302:1552-1560, 2019. © 2018 American Association for Anatomy.

The sub/supercritical water oxidation (SCWO) of wastewater with high concentrations of pollutants from tall oil rosin production base was studied under the temperature range of 320°C–420°C and the pressure range of 11–25 MPa. The results showed that after pretreatment with Ca(OH)2 for SO42− ions removal, around 385 mg/L SO42− remained which inhibited the oxidation activity by reducing the concentration of hydroxyl radicals (•OH). Since the wastewater compounds were mainly cyclic organic materials, higher O2 contents (stoichiometric ratio over 2.5) and temperatures (over 380°C) are favorable for TOC removal. With O2 SR = 2.5 and T = 420°C, the TOC removal reached almost 100% (99.89%) in 30 min. A global kinetic model for TOC removal during SCWO treatment was built during the research. The kinetic data acquired through the model were fitted to a power-law function, and the data correlated well with the experimental data. © 2016 American Institute of Chemical Engineers Environ Prog, 35: 975–981, 2016