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Your search keyword '"Junginger, H."' showing total 19 results
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19 results on '"Junginger, H."'

2. Modeling the impacts of wood pellet demand on forest dynamics in southeastern United States

Author

Duden, Anna S., Verweij, Pita A., Junginger, H. Martin, Abt, Robert C., Henderson, Jesse D., Dale, Virginia H., Kline, Keith L., Karssenberg, Derek, Verstegen, Judith A., Faaij, André P.C., van der Hilst, Floor, Biobased Economy, Energy System Analysis, Landdegradatie en aardobservatie, Energy and Resources, Landscape functioning, Geocomputation and Hydrology, Biobased Economy, Energy System Analysis, Landdegradatie en aardobservatie, Energy and Resources, and Landscape functioning, Geocomputation and Hydrology

Subjects
020209 energy, Biodiversity, spatial variation, Bioengineering, HARVEST, 02 engineering and technology, bioenergy, Ecosystem services, BIOMASS, land-use change, CARBON, Environmental protection, Bioenergy, southeastern USA, Urbanization, 0202 electrical engineering, electronic engineering, information engineering, Land use, land-use change and forestry, Renewable Energy, BIOENERGY PRODUCTION, Biomass (ecology), LAND-COVER CHANGE, Forest dynamics, Land use, Sustainability and the Environment, Renewable Energy, Sustainability and the Environment, wood pellets, AVAILABILITY, modeling, MARKET, Environmental science, BIODIVERSITY, TRANSITION, NORTH-CAROLINA
Abstract

The export of wood pellets from the southeastern United States (USA) has grown significantly in recent years, following rising demand from Europe. Increased wood pellet demand could lead to spatially variable changes in timberland management and area in the USA. This study presents an assessment of the impacts of increasing wood pellet demand (an additional 11.6 Mt by 2030) on land-use dynamics, taking into account developments in other wood product markets as well as expected changes in other land uses. An economic model for the forest sector of the southeastern USA (SRTS) was linked to a land-use change model (PLUC) to identify potential locations of land-use change following scenarios of demand for pellets and other wood products. Projections show that in the absence of additional demand for wood pellets, natural timberland area is projected to decline by 450-15 000 km(2) by 2030, mainly through urbanization and pine plantation establishment. Under the high wood pellet demand scenario, more (2000-7500 km(2)) natural timberland area is retained and more (8000-20 000 km(2)) pine plantation is established. Shifts from natural timberland to pine plantation occur predominantly in the Atlantic coastal region. Future work will assess the impact of projected transitions in natural timberland and pine plantations on biodiversity and carbon storage. This modeling framework can be applied for multiple scenarios and land-use projections to identify locations of timberland area changes for the whole southeastern USA, thereby informing the debate about potential impacts of wood pellet demand on land-use dynamics and environmental services. (c) 2017 The Authors. Biofuels, Bioproducts and Biorefining published by Society of Chemical Industry and John Wiley & Sons, Ltd.

Published
2017
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3. Modeling the impacts of wood pellet demand on forest dynamics in southeastern United States

Author

Biobased Economy, Energy System Analysis, Landdegradatie en aardobservatie, Energy and Resources, Landscape functioning, Geocomputation and Hydrology, Duden, Anna S., Verweij, Pita A., Junginger, H. Martin, Abt, Robert C., Henderson, Jesse D., Dale, Virginia H., Kline, Keith L., Karssenberg, Derek, Verstegen, Judith A., Faaij, André P.C., van der Hilst, Floor, Biobased Economy, Energy System Analysis, Landdegradatie en aardobservatie, Energy and Resources, Landscape functioning, Geocomputation and Hydrology, Duden, Anna S., Verweij, Pita A., Junginger, H. Martin, Abt, Robert C., Henderson, Jesse D., Dale, Virginia H., Kline, Keith L., Karssenberg, Derek, Verstegen, Judith A., Faaij, André P.C., and van der Hilst, Floor

Published
2017

19. Evidence of P-glycoprotein mediated apical to basolateral transport of flunisolide in human broncho-tracheal epithelial cells (Calu-3).

Author

Florea BI, van der Sandt IC, Schrier SM, Kooiman K, Deryckere K, de Boer AG, Junginger HE, and Borchard G

Subjects
ATP Binding Cassette Transporter, Subfamily B, Member 1 antagonists & inhibitors, ATP Binding Cassette Transporter, Subfamily B, Member 1 metabolism, Animals, Biological Transport drug effects, Bronchi cytology, Bronchi metabolism, Cell Line, Cell Polarity, Cell Survival, Cyclosporins pharmacology, Deoxyglucose pharmacology, Dibenzocycloheptenes pharmacology, Epithelial Cells cytology, Humans, Immunoblotting, Mass Spectrometry, Microscopy, Confocal, Quinolines pharmacology, Sodium Azide pharmacology, Temperature, Time Factors, Trachea cytology, Trachea metabolism, Verapamil pharmacology, ATP Binding Cassette Transporter, Subfamily B, Member 1 physiology, Epithelial Cells metabolism, Fluocinolone Acetonide analogs & derivatives, Fluocinolone Acetonide metabolism
Abstract

1. Transepithelial transport of flunisolide was studied in reconstituted cell monolayers of Calu-3, LLC-PK1 and the MDR1-P-glycoprotein transfected LLC-MDR1 cells. 2. Flunisolide transport was polarized in the apical (ap) to basolateral (bl) direction in Calu-3 cells and was demonstrated to be ATP-dependent. In LLC-MDR1 cells, flunisolide was transported in the bl to ap direction and showed no polarization in LLC-PK1 cells. 3. Non-specific inhibition of cellular metabolism at low temperature (4 degrees C) or by 2-deoxy-D-glucose (2-d-glu) and sodium azide (NaN(3)) abolished the polarized transport. Polarized flunisolide transport was also inhibited by the specific Pgp inhibitors verapamil, SDZ PSC 833 and LY335979. 4. Under all experimental conditions and in the presence of all used inhibitors, no decrease in the TransEpithelial Electrical Resistance (TEER) values was detected. From all inhibitors used, only the general metabolism inhibitors 2-deoxy-D-glucose and NaN(3), decreased the survival of Calu-3 cells. 5. Western blotting analysis and confocal laser scanning microscopy demonstrated the presence of MDR1-Pgp at mainly the basolateral side of the plasma membrane in Calu-3 cells and at the apical side in LLC-MDR1 cells. Mass spectroscopy studies demonstrated that flunisolide is transported unmetabolized across Calu-3 cells. 6. In conclusion, these results show that the active ap to bl transport of flunisolide across Calu-3 cells is facilitated by MDR1-Pgp located in the basolateral plasma membrane.

Published
2001
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