Search

Objective: Objective assessment of nasal patency in patients with nasal septal deviation should be required to determine the severity of the symptoms. The purpose of this study was to compare results of nasal sound spectral analysis (NSSA) with results of 4-phase rhinomanometry.Method: NSSA and 4-phase rhinomanometry were performed on 53 patients with nasal septal deviation and 55 healthy subjects. Cutoffs for NSSA and 4-phase rhinomanometry were defined by receiver operating characteristic analysis.Results: A significant difference was observed in either NSSA values or 4-phase rhinomanometry values between the nasal deviated patients and the control group (P < .001). A correlation was observed in patients between NSSA results of nasal intensity (dB) and its frequency (Hz) at a frequency range of 2 to 4 kHz and 4-phase results of effective resistance and verteresistance. No significant differences in terms of sensitivity of NSSA and 4-phase rhinomanometry (79.3% versus 75.5%), specificity (80.0% versus 85...

Objectives: Caffeic acids are known to have anti-oxidant, anti-inflammatory, immunomodulatory, and tissue reparative effects. The purposes of this study were to determine the effect of caffeic acid on transforming growth factor (TGF)-β1-induced myofibroblast differentiation and collagen production, and to determine whether caffeic acid is involved in the antioxidant effect.Method: Nasal polyp-derived fibroblasts (NPDFs) were pre-treated with caffeic acid (5-25 µM) for 2 hours and stimulated with TGF-β1 (5 ng/mL) for 24 hours. The expression of α-SMA, collagen types I and III, and Nox4 mRNA was determined by a reverse transcription-polymerase chain reaction, and the expression of α-SMA protein was determined by immunofluorescence microscopy. The amount of total soluble collagen production was analyzed by the Sircol collagen dye-binding assay. The reactive oxygen species (ROS) generated by NPDFs were determined using 2′,7′-dichlorfluorescein-diacetate. siNox4 was used to determine the effect of Nox4.Results...