1. Imaging asynchronous mechanical activation of the paced heart with tagged MRI
- Author
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Joshua E. Tsitlik, Henry R. Halperin, William C. Hunter, Frits W. Prinzen, Bradley T. Wyman, and Elliot R. McVeigh
- Subjects
medicine.medical_specialty ,Heart disease ,Heart Ventricles ,Article ,Free wall ,Dogs ,Heart Conduction System ,Electrical conduction ,Internal medicine ,Image Processing, Computer-Assisted ,medicine ,Animals ,Radiology, Nuclear Medicine and imaging ,Heart Atria ,Systole ,business.industry ,Cardiac Pacing, Artificial ,Anatomy ,medicine.disease ,Magnetic Resonance Imaging ,Myocardial Contraction ,medicine.anatomical_structure ,Dynamic models ,Entire left ventricle ,Circulatory system ,cardiovascular system ,Cardiology ,Right atrium ,business - Abstract
A method for imaging the rapid temporal-spatial evolution of myocardial deformations in the paced heart is proposed. High time resolution-tagged MR images were obtained after stimulation of the myocardium with an MR-compatible pacing system. The images were analyzed to reconstruct dynamic models of local 3D strains over the entire left ventricle during systole. Normal canine hearts were studied in vivo with pacing sites on the right atrium, left ventricular free wall and right ventricular apex. This method clearly resolved local variations in myocardial contraction patterns caused by ventricular pacing. Potential applications are noninvasive determination of electrical conduction abnormalities and the evaluation of new pacing therapies.
- Published
- 1998
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