9 results on '"Joshua A. Gordon"'
Search Results
2. The two solitudes of Canadian nativism: Explaining the absence of a competitive anti‐immigration party in Canada
- Author
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Clifton van der Linden, Sanjay Jeram, and Joshua C. Gordon
- Subjects
Arts and Humanities (miscellaneous) ,Political economy ,Political science ,Political Science and International Relations ,Geography, Planning and Development ,Psychological nativism ,Anti immigration - Published
- 2019
3. Tendon Biomechanics and Crimp Properties Following Fatigue Loading Are Influenced by Tendon Type and Age in Mice
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Benjamin R. Freedman, Joshua A. Gordon, Joseph J. Sarver, Mark R. Buckley, Andrey Zuskov, and Louis J. Soslowsky
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musculoskeletal diseases ,Aging ,Materials science ,0206 medical engineering ,Strain (injury) ,02 engineering and technology ,In Vitro Techniques ,Article ,Viscoelasticity ,Weight-Bearing ,03 medical and health sciences ,0302 clinical medicine ,Patellar Ligament ,Ultimate tensile strength ,medicine ,Animals ,Orthopedics and Sports Medicine ,030203 arthritis & rheumatology ,Biomechanics ,musculoskeletal system ,medicine.disease ,020601 biomedical engineering ,Biomechanical Phenomena ,Tendon ,Mice, Inbred C57BL ,medicine.anatomical_structure ,Flexor Digitorum Longus ,Crimp ,Ligament ,Female ,Biomedical engineering - Abstract
In tendon, type-I collagen assembles together into fibrils, fibers, and fascicles that exhibit a wavy or crimped pattern that uncrimps with applied tensile loading. This structural property has been observed across multiple tendons throughout aging and may play an important role in tendon viscoelasticity, response to fatigue loading, healing, and development. Previous work has shown that crimp is permanently altered with the application of fatigue loading. This opens the possibility of evaluating tendon crimp as a clinical surrogate of tissue damage. The purpose of this study was to determine how fatigue loading in tendon affects crimp and mechanical properties throughout aging and between tendon types. Mouse patellar tendons (PT) and flexor digitorum longus (FDL) tendons were fatigue loaded while an integrated plane polariscope simultaneously assessed crimp properties at P150 and P570 days of age to model mature and aged tendon phenotypes (N = 10-11/group). Tendon type, fatigue loading, and aging were found to differentially affect tendon mechanical and crimp properties. FDL tendons had higher modulus and hysteresis, whereas the PT showed more laxity and toe region strain throughout aging. Crimp frequency was consistently higher in FDL compared with PT throughout fatigue loading, whereas the crimp amplitude was cycle dependent. This differential response based on tendon type and age further suggests that the FDL and the PT respond differently to fatigue loading and that this response is age-dependent. Together, our findings suggest that the mechanical and structural effects of fatigue loading are specific to tendon type and age in mice. © 2019 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 38:36-42, 2020.
- Published
- 2019
4. Ultrasound‐Guided Dry Needling of the Healthy Rat Supraspinatus Tendon Elicits Early Healing Without Causing Permanent Damage
- Author
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Susan M. Schultz, Louis J. Soslowsky, Joshua A. Gordon, Viviane Khoury, Mengcun Chen, and Corinne N. Riggin
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Male ,Percutaneous ,0206 medical engineering ,Population ,Tendinosis ,02 engineering and technology ,Article ,Rotator Cuff Injuries ,Rats, Sprague-Dawley ,Rotator Cuff ,03 medical and health sciences ,0302 clinical medicine ,Animals ,Medicine ,Orthopedics and Sports Medicine ,Ultrasonography, Doppler, Color ,education ,Ultrasonography, Interventional ,030203 arthritis & rheumatology ,Wound Healing ,Dry needling ,education.field_of_study ,business.industry ,Ultrasound ,Blood flow ,medicine.disease ,020601 biomedical engineering ,Biomechanical Phenomena ,Rats ,Tendon ,medicine.anatomical_structure ,Anesthesia ,Dry Needling ,Tendinopathy ,business - Abstract
Overuse-induced tendinopathy is highly prevalent in the general population. Percutaneous fenestration, or dry needling, techniques have been increasing in popularity, but despite their current use, there are no controlled laboratory studies to provide fundamental support for this practice. The objective of this study was to establish a model for percutaneous needling of the rat supraspinatus tendon using ultrasound guidance and to evaluate the biological response of needling healthy tendon. A total of 44 male Sprague-Dawley rats (477 ± 39 g) were used to evaluate the effect of dry needling on healthy supraspinatus tendon properties. Ten rats were reserved as un-needled control animals, and the remaining animals underwent either mild or moderate bilateral needling protocols and were sacrificed at 1 or 6 weeks post-needling (n = 8-10/group). Color Doppler ultrasound imaging was performed to analyze blood flow within the tendon. Histological and immunohistochemical analyses were used to determine cellular, inflammatory, and extracellular matrix properties of the tissue. Finally, quasi-static tensile mechanical analysis was performed to obtain viscoelastic, structural, and material properties to evaluate the tendon healing outcome. Data were tested for normality, and then two-way analysis of variance tests were performed followed by post hoc tests for multiple comparisons. Both the mild and moderate needling groups caused a transient healing response at early time points as shown by a statistically significant (p < 0.05) reduction in mechanical properties, and increase in blood flow, inflammation, and production of collagen III and glycosaminoglycans as compared to the control. Furthermore, mild needling properties returned to or exceeded pre-needling values at the 6-week time point. Clinical significance: Needling the rat supraspinatus tendon is a feasible technique that causes a transient healing response followed by a return to, or improvement of, normal tendon properties, indicating potential applicability in understanding the effects of current practices utilizing dry needling of tendons in humans. © 2019 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 37:2035-2042, 2019.
- Published
- 2019
5. Association of clinical measures of periodontal disease with blood pressure and hypertension among postmenopausal women
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Joshua H Gordon, Robert J. Genco, Jean Wactawski-Wende, Kathleen M. Hovey, Thomas R. Cimato, Michael J. LaMonte, and Jiwei Zhao
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medicine.medical_specialty ,Cross-sectional study ,Osteoporosis ,Bleeding on probing ,Blood Pressure ,030204 cardiovascular system & hematology ,Article ,03 medical and health sciences ,0302 clinical medicine ,Periodontal disease ,Internal medicine ,Periodontal Attachment Loss ,medicine ,Tooth loss ,Humans ,Prospective Studies ,Prospective cohort study ,Periodontal Diseases ,Periodontitis ,business.industry ,030206 dentistry ,medicine.disease ,Postmenopause ,Cross-Sectional Studies ,Blood pressure ,Hypertension ,Periodontics ,Female ,medicine.symptom ,business - Abstract
BACKGROUND Hypertension and periodontal disease are common conditions among postmenopausal women. Periodontal disease has been found associated with hypertension in previous studies, but data in postmenopausal women is limited. METHODS We assessed the cross-sectional associations of clinically measured periodontal disease with prevalent hypertension and measured systolic blood pressure (SBP) among 1341 postmenopausal women enrolled in the Buffalo Osteoporosis and Periodontal Disease (OsteoPerio) study, an ancillary study of the Women's Health Initiative-Observational Study. RESULTS Clinical attachment level (CAL) and number of teeth missing were positively associated with SBP among those not taking antihypertensive medication in crude and multivariable adjusted linear regression models (both P
- Published
- 2018
6. Ultrasonographic Evaluation of Zone II Partial Flexor Tendon Lacerations of the Fingers: A Cadaveric Study
- Author
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Viviane Khoury, Nikolas H. Kazmers, David R. Steinberg, Kristen L. Buterbaugh, David J. Bozentka, and Joshua A. Gordon
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030222 orthopedics ,medicine.medical_specialty ,Radiological and Ultrasound Technology ,Flexor tendon ,business.industry ,030230 surgery ,musculoskeletal system ,Confidence interval ,Surgery ,Tendon ,Linear array ,03 medical and health sciences ,0302 clinical medicine ,medicine.anatomical_structure ,medicine ,Standard test ,Radiology, Nuclear Medicine and imaging ,Ultrasonography ,business ,Cadaveric spasm ,Tendon laceration - Abstract
Objectives Accurate assessment of zone II partial flexor tendon lacerations in the finger is clinically important. Surgical repair is recommended for lacerations of greater than 50% to 60%. Our goal was to evaluate ultrasonographic test characteristics and accuracy in identifying partial flexor tendon lacerations in a cadaveric model. Methods From fresh-frozen above-elbow human cadaveric specimens, 32 flexor digitorum profundus tendons were randomly selected to remain intact or receive low- or high-grade lacerations involving 10% to 40% and 60% to 90% of the radioulnar width within Verdan Zone II, respectively. Static and dynamic ultrasonography using a linear array 14-MHz transducer was performed by a blinded musculoskeletal radiologist. Sensitivities, specificities, and other standard test performance metrics were calculated. Actual and measured percentages of tendon laceration were compared by the paired t test. Results After randomization, 24 tendons were lacerated (12 low- and 12 high-grade), whereas 8 remained intact. The sensitivity and specificity in detecting the presence versus absence of a partial laceration were 0.54 and 0.75, respectively, with positive and negative likelihood ratio values of 2.17 and 0.61. For low-grade lacerations, the sensitivity and specificity were 0.25 and 0.85, compared to 0.83 and 0.85 for high-grade lacerations. Ultrasonography underestimated the percentage of tendon involvement by a mean of 18.1% for the study population as a whole (95% confidence interval, 9.0% to 27.2%; P
- Published
- 2017
7. Scapular dyskinesis is detrimental to shoulder tendon properties and joint mechanics in a rat model
- Author
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Stephen S. Liu, Louis J. Soslowsky, Pankti R. Bhatt, Sarah M. Yannascoli, Katherine E. Reuther, Joshua A. Gordon, Adam C. Caro, Andrew F. Kuntz, Stephen J. Thomas, Rameen P. Vafa, and Jennica J. Tucker
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musculoskeletal diseases ,business.industry ,Anatomy ,musculoskeletal system ,Tendon ,medicine.anatomical_structure ,Animal model ,Scapula ,Medicine ,Orthopedics and Sports Medicine ,Rotator cuff ,Shoulder joint ,business ,Range of motion ,Pathological ,Scapular dyskinesis - Abstract
Shoulder tendon injuries are frequently seen in the presence of abnormal scapular motion, termed scapular dyskinesis. The cause and effect relationship between scapular dyskinesis and shoulder injury has not been directly defined. We developed and used an animal model to examine the initiation and progression of pathological changes in the rotator cuff and biceps tendon. Sixty male Sprague-Dawley rats were randomized into two groups: nerve transection (to induce scapular dyskinesis, SD) or sham nerve transection (control). The animals were euthanized 4 and 8 weeks after surgery. Shoulder function and passive joint mechanics were evaluated over time. Tendon mechanical, histological, organizational, and compositional properties were evaluated at both time points. Gross observation demonstrated alterations in scapular motion, consistent with scapular "winging." Shoulder function, passive internal range of motion, and tendon mechanical properties were significantly altered. Histology results, consistent with tendon pathology (rounded cell shape and increased cell density), were observed, and protein expression of collagen III and decorin was altered. This study presents a new model of scapular dyskinesis that can rigorously evaluate cause and effect relationships in a controlled manner. Our results identify scapular dyskinesis as a causative mechanical mechanism for shoulder tendon pathology.
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- 2014
8. Bone density in post-pubertal adolescent survivors of childhood brain tumors
- Author
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Laurie E. Cohen, Joshua H. Gordon, Catherine M. Gordon, Mark W. Kieran, Erica Popovsky, Henry A. Feldman, and Nina N. Sainath
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Male ,musculoskeletal diseases ,Peak bone mass ,medicine.medical_specialty ,Adolescent ,Bone density ,medicine.medical_treatment ,Urology ,Article ,Growth hormone deficiency ,Fractures, Bone ,Absorptiometry, Photon ,Bone Density ,Risk Factors ,Humans ,Medicine ,Survivors ,Age of Onset ,Child ,Retrospective Studies ,Femoral neck ,Bone mineral ,Radiotherapy ,Brain Neoplasms ,Human Growth Hormone ,business.industry ,Hypogonadism ,Puberty ,Chemoradiotherapy ,Hematology ,musculoskeletal system ,medicine.disease ,Surgery ,Radiation therapy ,medicine.anatomical_structure ,Oncology ,Pediatrics, Perinatology and Child Health ,Menarche ,Female ,Cranial Irradiation ,Age of onset ,business - Abstract
Background Childhood cancer survivors are at high risk for reduced bone mineral density (BMD). Our objective was to determine whether post-pubertal adolescent survivors of brain tumors, whose tumor or treatments placed them at risk for pituitary hormone deficiencies, have low BMD near time of peak bone mass accrual, and to assess risk factors for decreased BMD. Procedure Chart review of 36 post-pubertal adolescents with history of tumor or radiation therapy (RT) of the hypothalamic–pituitary area who had undergone BMD screening via dual-energy X-ray absorptiometry (DXA). Results Age at DXA was 16.9 ± 1.9 years (mean ± SD). Time since diagnosis was 8.5 ± 3.6 years. Median BMD Z scores were –0.95 (range −2.7 to 1.7) at the femoral neck, −1.20 (−3.6 to 1.8) at the hip, and −0.90 (−3.7 to 1.8) at the spine. Bone mineral apparent density (BMAD) Z scores were −0.23 (−2.7 to 1.9) at the femoral neck and −0.45 (−3.0 to 2.3) at the spine. Those with history of ≥1 fracture had lower BMD Z scores of the femoral neck, total hip, and spine (P
- Published
- 2011
9. Oral Microbiome Is Associated With Incident Hypertension Among Postmenopausal Women
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Michael J. LaMonte, Joshua H. Gordon, Patricia Diaz‐Moreno, Christopher A. Andrews, Daichi Shimbo, Kathleen M. Hovey, Michael J. Buck, and J. Wactawski‐Wende
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epidemiology ,hypertension ,menopause ,microbiome ,women’s health ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Background Oral microbiota are thought to influence blood pressure (BP) regulation. However, epidemiological data supporting this hypothesis are limited. We examined associations between oral microbiota, BP, and incident hypertension in postmenopausal women. Methods and Results Baseline (1997–2001) examinations were completed on 1215 women (mean age, 63 years) during which subgingival plaque was collected, BP was measured, and medical and lifestyle histories and medication inventory were obtained. Microbiome composition of subgingival plaque was measured using 16S ribosomal RNA gene amplicon sequencing. Baseline measured BP was defined as normotensive (systolic
- Published
- 2022
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