1. Microvascular anastomosis using a photochemical tissue bonding technique
- Author
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Jonathan M. Winograd, Anne C. O'Neill, Irene E. Kochevar, T. Shane Johnson, Robert W. Redmond, Kenneth E. Bujold, Mark A. Randolph, and Jose Zeballos
- Subjects
Male ,Microsurgery ,medicine.medical_specialty ,Brachial Artery ,Photochemistry ,Swine ,Dermatology ,Femoral artery ,In Vitro Techniques ,Anastomosis ,Rats, Sprague-Dawley ,Suture (anatomy) ,In vivo ,medicine.artery ,medicine ,Animals ,Aneurysm formation ,Vascular Patency ,Analysis of Variance ,Rose Bengal ,business.industry ,Suture Techniques ,Rats ,Surgery ,Femoral Artery ,Disease Models, Animal ,Microvascular anastomosis ,Feasibility Studies ,Tissue Adhesives ,Thermal damage ,Laser Therapy ,business ,Ex vivo - Abstract
Background and Objectives Photochemical tissue bonding (PTB) combines photoactive dyes with visible light to create fluid-tight seals between tissue surfaces without causing collateral thermal damage. The potential of PTB to improve outcomes over standard of care microsurgical reanastomoses of blood vessels in ex vivo and in vivo models was evaluated. Study Design The mechanical strength and integrity of PTB and standard microsurgical suture repairs in ex vivo porcine brachial arteries (n = 10) were compared using hydrostatic testing of leak point pressure (LPP). Femoral artery repair in vivo was measured in Sprague–Dawley rats using either standard microvascular sutures (n = 20) or PTB (n = 20). Patency was evaluated at 6 hours (n = 10) and 8 weeks post-repair (n = 10) for each group. Results PTB produced significantly higher LPPs (1,100± 150 mmHg) than suture repair (350±40 mmHg, P
- Published
- 2007