1. Human glioblastoma-initiating cells invade specifically the subventricular zones and olfactory bulbs of mice after striatal injection
- Author
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Yves-Gauthier Boulanger, Didier Martin, Manuel Deprez, Pierre A. Robe, Vincent Bours, Fabian Provenzano, Jessica Nassen, Bernard Rogister, Jérôme Kroonen, and Valérie Capraro
- Subjects
Olfactory system ,Cancer Research ,Transplantation, Heterologous ,Central nervous system ,Mice, Nude ,Biology ,medicine.disease_cause ,Cerebral Ventricles ,Mice ,Cell Movement ,medicine ,Animals ,Humans ,neoplasms ,Tropism ,Brain Neoplasms ,Neurogenesis ,Cell migration ,Olfactory Bulb ,Corpus Striatum ,nervous system diseases ,Olfactory bulb ,medicine.anatomical_structure ,nervous system ,Oncology ,Immunology ,Neoplastic Stem Cells ,Cancer research ,Female ,Stem cell ,Glioblastoma ,Carcinogenesis ,Neoplasm Transplantation - Abstract
In patients with glioblastoma multiforme, recurrence is the rule despite continuous advances in surgery, radiotherapy and chemotherapy. Within these malignant gliomas, glioblastoma stem cells or initiating cells have been recently described, and they were shown to be specifically involved in experimental tumorigenesis. In this study, we show that some human glioblastoma cells injected into the striatum of immunodeficient nude mice exhibit a tropism for the subventricular zones. There and similarily to neurogenic stem cells, these subventricular glioblastoma cells were then able to migrate toward the olfactory bulbs. Finally, the glioblastoma cells isolated from the adult mouse subventricular zones and olfactory bulbs display high tumorigenicity when secondary injected in a new mouse brain. Together, these data suggest that neurogenic zones could be a reservoir for particular cancer-initiating cells.
- Published
- 2010
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