1. Association of copy number variation across the genome with neuropsychiatric traits in the general population
- Author
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Anita Thapar, Michael Conlon O'Donovan, Stan Zammit, Santiago Rodriguez, James T.R. Walters, Joanna Martin, Michael John Owen, Tom R. Gaunt, Anna L. Guyatt, Evie Stergiakouli, Dheeraj Rai, and George Kirov
- Subjects
Male ,0301 basic medicine ,Longitudinal study ,Autism Spectrum Disorder ,Intelligence ,Anxiety ,0302 clinical medicine ,Longitudinal Studies ,Copy-number variation ,Child ,Research Articles ,Genetics (clinical) ,Genetics ,education.field_of_study ,Depression ,Mental Disorders ,ALSPAC ,Psychiatry and Mental health ,Phenotype ,Autism spectrum disorder ,Schizophrenia ,Female ,medicine.symptom ,Research Article ,Adult ,genetic epidemiology ,Adolescent ,DNA Copy Number Variations ,Population ,Polymorphism, Single Nucleotide ,Structural variation ,03 medical and health sciences ,Cellular and Molecular Neuroscience ,mental disorders ,medicine ,Humans ,Genetic Predisposition to Disease ,education ,childhood ,business.industry ,structural variation ,medicine.disease ,030104 developmental biology ,Genetic epidemiology ,Attention Deficit Disorder with Hyperactivity ,business ,030217 neurology & neurosurgery ,Genome-Wide Association Study - Abstract
Copy number variants (CNVs) are associated with psychiatric conditions in clinical populations. The relationship between rare CNV burden and neuropsychiatric traits in young, general populations is underexplored. A total of 6,807 children from the Avon Longitudinal Study of Parents and Children (ALSPAC) were studied. CNVs were inferred from single nucleotide polymorphism-array data using PennCNV. After excluding children with known candidate CNVs for schizophrenia (SCZ), rare (
- Published
- 2018