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3. Baseline incision characteristics and early scar maturation indices following cardiac device implantation

Author

Nishaki Kiran Mehta, Katerina Morgaenko, David Haines, Edward Rojas‐Pena, Brittney Heard, Rohit Malhotra, Andrew Darby, James Michael Mangrum, Pamela Mason, Christopher Campbell, and Kenneth Bilchick

Subjects
cardiac implantable devices, durometer measurements, incision characteristics, scar healing, skin thickness, wound complications, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Abstract Aims Dermatologic evaluation for cardiac implantable electronic devices (CIEDs) has not been established. We sought to ascertain baseline wound scar features using quantifiable surgical tools and scar scales on post‐CIED patients. Methods A single‐center, prospective observational case‐control study was performed where 92 study subjects (40 healthy volunteers and 52 post‐CIED patients) completed the study. Durometer was used to quantify skin pliability before CIED placement, postprocedure, and 2 weeks postprocedure. Higher durometer readings signified reduced skin pliability. Durometer readings were compared to the patients’ contralateral pectoral skin and to a healthy volunteer's cohort skin within the prepectoral region. Patient wounds were observed and graded using the Patient Observer Scar Assessment Scale (POSAS) and Manchester Scar Scale (MSS). Results Baseline pectoral skin pliability readings were similar in healthy volunteers and CIED patient population. In comparison to preprocedural measurements, surgical site skin pliability decreased in postprocedural and 2 weeks follow‐up time points (P‐value .004 and 75 over time, P = .008). POSAS evaluations showed on average a thin painless hypopigmented scar with moderate stiffness. MSS scar evaluation showed a palpable scar with slight contour differences and color mismatch and appeared to be slightly better in the African American population. There was no difference in scar characteristics with preprocedural use of antiplatelet or anticoagulation or staple closure or gender. Conclusions Serial measurements could be of value for development of new strategies for cosmesis and improved wound healing.

Published
2021
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6. Deep Resequencing of the 1q22 Locus in Non‐Lobar Intracerebral Hemorrhage

Author

Parodi, Livia, primary, Comeau, Mary E., additional, Georgakis, Marios K., additional, Mayerhofer, Ernst, additional, Chung, Jaeyoon, additional, Falcone, Guido J., additional, Malik, Rainer, additional, Demel, Stacie L., additional, Worrall, Bradford B., additional, Koch, Sebastian, additional, Testai, Fernando D., additional, Kittner, Steven J., additional, McCauley, Jacob L., additional, Hall, Christiana E., additional, Mayson, Douglas J., additional, Elkind, Mitchell S.V., additional, James, Michael L., additional, Woo, Daniel, additional, Rosand, Jonathan, additional, Langefeld, Carl D., additional, and Anderson, Christopher D., additional

Published
2023
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12. Characteristics and outcomes of young patients with laryngeal cancer: National <scp>hospital‐based</scp> retrospective cohort analysis

Author

Alex Yang, Priscilla Tanamal, Kathleen Tibbetts, Baran Sumer, James‐Michael Blackwell, Kelly Schostag, David Sher, and Andrew Day

Subjects
Cohort Studies, Male, Otorhinolaryngology, Papillomavirus Infections, Humans, Female, Middle Aged, Laryngeal Neoplasms, Hospitals, Retrospective Studies
Abstract

The relative incidence of laryngeal cancer is rising in young patients, yet their characteristics, risk factors, and outcomes relative to older patients are poorly understood.Retrospective cohort analysis of the National Cancer Database from 2006 to 2015.Among 25 029 total patients, 923 (3.7%) were young (45 years old) and 3266 underwent tumor HPV testing. Compared to older patients, a greater proportion of young patients were female (30.3%, 23.3%; p 0.001) and seen with high-risk HPV-positive tumors (29.9%, 12.4%; p 0.001). In subset analyses of young patients, females with higher income (≥$38 000) exhibited a decreased risk of overall mortality compared to all other sex-income subcategories (adjusted hazard ratio [aHR]: 0.43, 95% confidence interval [CI]: 0.25-0.72). In subset analyses of patients of all ages with known tumor HPV status, patients with high-risk HPV-positive tumors exhibited a reduced risk of all-cause mortality (aHR: 0.74, 95%CI: 0.60-0.92, p = 0.007).The interdependent associations between age, sex, tumor HPV status, and income on laryngeal cancer outcomes warrant further investigation.

Published
2022

13. Engineered bacteria producing aryl‐hydrocarbon receptor agonists protect against ethanol‐induced liver disease in mice

Author

Kouno, Tetsuya, primary, Zeng, Suling, additional, Wang, Yanhan, additional, Duan, Yi, additional, Lang, Sonja, additional, Gao, Bei, additional, Hartmann, Phillipp, additional, Cabré, Noemí, additional, Llorente, Cristina, additional, Galbert, Chloé, additional, Emond, Patrick, additional, Sokol, Harry, additional, James, Michael, additional, Chao, Chun Cheih, additional, Gao, Jian‐Rong, additional, Perreault, Mylene, additional, Hava, David L., additional, and Schnabl, Bernd, additional

Published
2023
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19. The multifaceted nature of the response to adversity in an Italian sample of refugee community leaders

Author

James Michael Perry, Alessandra Talamo, Giampaolo Nicolais, Caterina Nicolais, and Camilla Modesti

Subjects
Motivation, Refugees, Civil society, media_common.quotation_subject, Refugee, Exploratory research, Resistance (psychoanalysis), Suicidal Ideation, Stress Disorders, Post-Traumatic, Psychiatry and Mental health, Clinical Psychology, Distress, Prevalence, medicine, Humans, Psychological resilience, medicine.symptom, Thematic analysis, Psychology, Suicidal ideation, Social psychology, media_common
Abstract

The end of the last decade saw record numbers of refugee arrivals to Italy, straining the existing reception and integration systems. Although significant research attention has focused on the prevalence of posttraumatic stress disorder (PTSD), depression, and suicidal ideation in refugee populations, there are increasing calls to study the interactions between distress, resilience, and positive outcomes of adversity. To fully understand the complexity of the refugee experience, these voices must be heard in dialogue. Studies must be framed within a more nuanced view of refugees, characterizing them not exclusively as victims but also as advocates for their own well-being and the well-being of their communities. This exploratory study performed a thematic analysis of 15 interviews conducted with refugee community leaders in Italy, each a founder or leader of a community association and actively engaged in civil society. In keeping with Papadopoulos' (2007) construct of adversity-activated development, an inductive analysis identified three distinct patterns of positive adversity response: meaning, motivation, and mobilization. A deductive analysis identified the most appropriate theories of resilience to describe the sample, which included resilience as a dynamic positive adaptation and resilience as resistance to change in moral codes and personal value systems. The resulting image of refugee community leaders in Italy is that of individuals who are exposed to adversity and experiences of suffering and distress but safeguard their core values while positively adapting to a new country.

Published
2021

22. Extracapsular extension, pathologic node status, and adjuvant treatment in primary surgery patients with human papillomavirus <scp>‐mediated</scp> oropharyngeal cancer: National h <scp>ospital‐based</scp> retrospective cohort analysis

Author

Saad A. Khan, James-Michael Blackwell, Alex M. Yang, Ellen Wang, Priscilla J. Tanamal, Justin A. Bishop, David J. Sher, Randall S. Hughes, Andrew T. Day, and Baran D. Sumer

Subjects
medicine.medical_specialty, business.industry, medicine.medical_treatment, Hazard ratio, Cancer, Retrospective cohort study, Disease, medicine.disease, Confidence interval, Surgery, Clinical trial, Otorhinolaryngology, medicine, Human papillomavirus, business, Adjuvant
Abstract

BACKGROUND The significance of extracapsular extension (ECE) and adjuvant treatment paradigm in patients with surgically managed human papillomavirus-positive (HPV+) oropharyngeal cancer (OPC) is debated. METHODS National, hospital-based, retrospective cohort study of 2663 patients pN+ HPV+ OPC who underwent primary surgery. RESULTS Patients with ECE had a 1.74-times risk of death (95% confidence interval [CI]: 1.26-2.40, p = 0.001) compared to patients without ECE. Among patients with pN1, ECE-positive disease, risk of overall mortality was similar across treatment paradigms (surgery alone: ref; adjuvant radiation therapy [RT]: aHR: 0.81; 95% CI: 0.36-1.85; p = 0.62; adjuvant CRT: aHR: 0.66; 95% CI: 0.34-1.32; p = 0.24). Patients with pN2 ECE-positive disease treated with adjuvant RT alone exhibited similar risk of all-cause mortality (hazard ratio: 1.04, 95% CI: 0.24-4.47, p = 0.96) compared to adjuvant chemoradiation (CRT). In patients with advanced, ECE-positive disease (e.g., pT3-T4pN2), adjuvant CRT did not reduce the risk of overall mortality relative to adjuvant RT. CONCLUSION Although pathologic ECE negatively predicts for survival in patients with HPV+ OPC, our analyses support expansion of postoperative de-intensification clinical trial eligibility criteria in patients with ECE-positive disease.

Published
2021

26. On the outside looking in: roles of endogenous and exogenous strigolactones

Author

James Michael Bradley, Bruno Aquino, and Shelley Lumba

Subjects
0106 biological sciences, 0301 basic medicine, Parasitic plant, Plant Development, Endogeny, Plant Science, 01 natural sciences, Lactones, 03 medical and health sciences, Inorganic phosphate, Plant Growth Regulators, Mycorrhizae, Signalling molecules, Genetics, Symbiosis, Rhizosphere, integumentary system, biology, fungi, food and beverages, Phosphorus, Cell Biology, 15. Life on land, biology.organism_classification, Cell biology, Plant development, Quorum sensing, 030104 developmental biology, Arbuscular mycorrhizal, Heterocyclic Compounds, 3-Ring, 010606 plant biology & botany
Abstract

A collection of small molecules called strigolactones (SLs) act as both endogenous hormones to control plant development and as ecological communication cues between organisms. SL signalling overlaps with that of a class of smoke-derived compounds, karrikins (KARs), which have distinct yet overlapping developmental effects on plants. Although the roles of SLs in shoot and root development, in the promotion of arbuscular mycorrhizal (AM) fungal branching and in parasitic plant germination have been well characterized, recent data have illustrated broader roles for these compounds in the rhizosphere. Here, we review the known roles of SLs in development, growth of AM fungi and germination of parasitic plants to develop a framework for understanding the use of SLs as molecules of communication in the rhizosphere. It appears, for example, that there are many connections between SLs and phosphate utilization. Low phosphate levels regulate SL metabolism and, in turn, SLs sculpt root and shoot architecture to coordinate growth and optimize phosphate uptake from the environment. Plant-exuded SLs attract fungal symbionts to deliver inorganic phosphate (Pi) to the host. These and other examples suggest the boundary between exogenous and endogenous SL functions can be easily blurred and a more holistic view of these small molecules is likely to be required to fully understand SL biology. Related to this, we summarize and discuss evidence for a primitive role of SLs in moss as a quorum sensing-like molecule, providing a unifying concept of SLs as endogenous and exogenous signalling molecules.

Published
2020

28. Evaluation of a novel mechanical compression device for hematoma prevention and wound cosmesis after CIED implantation

Author

Rojas, Edward, primary, Morgaenko, Katerina, additional, Brown, Louis, additional, Kim, Sieu, additional, Mazimba, Sula, additional, Malhotra, Rohit, additional, Darby, Andrew, additional, Monfredi, Oliver, additional, Mason, Pamela, additional, Mangrum, James Michael, additional, Haines, David E., additional, Campbell, Christopher, additional, Bilchick, Kenneth, additional, and Mehta, Nishaki, additional

Published
2022
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30. BIOANALYSIS AND BIOTRANSFORMATION OF OLIGONUCLEOTIDE THERAPEUTICS BY LIQUID CHROMATOGRAPHY‐MASS SPECTROMETRY

Author

Jaeah Kim, Noha M. El Zahar, Michael G. Bartlett, and James Michael Sutton

Subjects
Bioanalysis, Oligonucleotide, Chemistry, Oligonucleotides, Computational biology, Condensed Matter Physics, Mass Spectrometry, General Biochemistry, Genetics and Molecular Biology, Specimen Handling, Analytical Chemistry, Biotransformation, Liquid chromatography–mass spectrometry, Spectroscopy, Chromatography, Liquid
Abstract

Since 2016, eight new oligonucleotide therapies have been approved which has led to increased interest in oligonucleotide analysis. There is a particular need for powerful bioanalytical tools to study the metabolism and biotransformation of these molecules. This review provides the background on the biological basis of these molecules as currently used in therapies. The article also reviews the current state of analytical methodology including state of the art sample preparation techniques, liquid chromatography-mass spectrometry methods, and the current limits of detection/quantitation. Finally, the article summarizes the challenges in oligonucleotide bioanalysis and provides future perspectives for this emerging field. © 2020 John Wiley & Sons Ltd.

Published
2020

31. Comparing detailed and less detailed pre‐lineup instructions

Author

Paulie Phillips, Brittany Race, Alexander P. Wolf, Nathalie Moriarty, James Michael Lampinen, and Andrew M. Smith

Subjects
business.industry, Law enforcement, Experimental and Cognitive Psychology, computer.software_genre, Identification (information), Arts and Humanities (miscellaneous), Developmental and Educational Psychology, Artificial intelligence, Psychology, business, computer, Natural language processing, Eyewitness identification, Expected utility hypothesis
Published
2020

36. Extracapsular extension, pathologic node status, and adjuvant treatment in primary surgery patients with human papillomavirus ‐mediated oropharyngeal cancer: National h ospital‐based retrospective cohort analysis

Author

Day, Andrew T., primary, Yang, Alex M., additional, Tanamal, Priscilla, additional, Blackwell, James‐Michael, additional, Wang, Ellen, additional, Sumer, Baran D., additional, Bishop, Justin A., additional, Hughes, Randall S., additional, Khan, Saad A., additional, and Sher, David J., additional

Published
2021
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40. Baseline incision characteristics and early scar maturation indices following cardiac device implantation

Author

Mehta, Nishaki Kiran, primary, Morgaenko, Katerina, additional, Haines, David, additional, Rojas‐Pena, Edward, additional, Heard, Brittney, additional, Malhotra, Rohit, additional, Darby, Andrew, additional, Mangrum, James Michael, additional, Mason, Pamela, additional, Campbell, Christopher, additional, and Bilchick, Kenneth, additional

Published
2021
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41. The role of context expectations and cost of reporting on prospective person memory performance

Author

James Michael Lampinen, Andrew C. Provenzano, and Kara N. Moore

Subjects
Arts and Humanities (miscellaneous), Context effect, 05 social sciences, 050501 criminology, Developmental and Educational Psychology, 0501 psychology and cognitive sciences, Experimental and Cognitive Psychology, Context (language use), Memory performance, Psychology, 050105 experimental psychology, 0505 law, Cognitive psychology
Published
2018

42. Social network analysis: Presenting an underused method for nursing research

Author

James Michael Parnell and Jennifer C. Robinson

Subjects
Nursing literature, 030504 nursing, Social network, Computer science, business.industry, Nursing research, Information Storage and Retrieval, Social Support, CINAHL, Data science, Article, Nursing Research, 03 medical and health sciences, 0302 clinical medicine, Research Design, Humans, 030212 general & internal medicine, 0305 other medical science, Complex adaptive system, business, Social network analysis, Research question, Qualitative Research, General Nursing, Qualitative research
Abstract

Aim This paper introduces social network analysis as a versatile method with many applications in nursing research. Background Social networks have been studied for years in many social science fields. The methods continue to advance but remain unknown to most nursing scholars. Design Discussion paper. Data sources English language and interpreted literature was searched from Ovid Healthstar, CINAHL, PubMed Central, Scopus and hard copy texts from 1965 - 2017. Discussion Social network analysis first emerged in nursing literature in 1995 and appears minimally through present day. To convey the versatility and applicability of social network analysis in nursing, hypothetical scenarios are presented. The scenarios are illustrative of three approaches to social network analysis and include key elements of social network research design. Implications for nursing The methods of social network analysis are underused in nursing research, primarily because they are unknown to most scholars. However, there is methodological flexibility and epistemological versatility capable of supporting quantitative and qualitative research. The analytic techniques of social network analysis can add new insight into many areas of nursing inquiry, especially those influenced by cultural norms. Furthermore, visualization techniques associated with social network analysis can be used to generate new hypotheses. Conclusion Social network analysis can potentially uncover findings not accessible through methods commonly used in nursing research. Social networks can be analysed based on individual-level attributes, whole networks and subgroups within networks. Computations derived from social network analysis may stand alone to answer a research question or incorporated as variables into robust statistical models.

Published
2018

43. Blood‐based biomarkers of human papillomavirus–associated cancers: A systematic review and meta‐analysis

Author

Balachandra, Sanjana, primary, Kusin, Samuel B., additional, Lee, Rebecca, additional, Blackwell, James‐Michael, additional, Tiro, Jasmin A., additional, Cowell, Lindsay G., additional, Chiang, Cheng‐Ming, additional, Wu, Shwu‐Yuan, additional, Varma, Sanskriti, additional, Rivera, Erika L., additional, Mayo, Helen G., additional, Ding, Lianghao, additional, Sumer, Baran D., additional, Lea, Jayanthi S., additional, Bagrodia, Aditya, additional, Farkas, Linda M., additional, Wang, Richard, additional, Fakhry, Carole, additional, Dahlstrom, Kristina R., additional, Sturgis, Erich M., additional, and Day, Andrew T., additional

Published
2020
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45. Environmental drivers of Sphagnum growth in peatlands across the Holarctic region

Author

Bengtsson, Fia, primary, Rydin, Håkan, additional, Baltzer, Jennifer L., additional, Bragazza, Luca, additional, Bu, Zhao‐Jun, additional, Caporn, Simon J. M., additional, Dorrepaal, Ellen, additional, Flatberg, Kjell Ivar, additional, Galanina, Olga, additional, Gałka, Mariusz, additional, Ganeva, Anna, additional, Goia, Irina, additional, Goncharova, Nadezhda, additional, Hájek, Michal, additional, Haraguchi, Akira, additional, Harris, Lorna I., additional, Humphreys, Elyn, additional, Jiroušek, Martin, additional, Kajukało, Katarzyna, additional, Karofeld, Edgar, additional, Koronatova, Natalia G., additional, Kosykh, Natalia P., additional, Laine, Anna M., additional, Lamentowicz, Mariusz, additional, Lapshina, Elena, additional, Limpens, Juul, additional, Linkosalmi, Maiju, additional, Ma, Jin‐Ze, additional, Mauritz, Marguerite, additional, Mitchell, Edward A. D., additional, Munir, Tariq M., additional, Natali, Susan M., additional, Natcheva, Rayna, additional, Payne, Richard J., additional, Philippov, Dmitriy A., additional, Rice, Steven K., additional, Robinson, Sean, additional, Robroek, Bjorn J. M., additional, Rochefort, Line, additional, Singer, David, additional, Stenøien, Hans K., additional, Tuittila, Eeva‐Stiina, additional, Vellak, Kai, additional, Waddington, James Michael, additional, and Granath, Gustaf, additional

Published
2020
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