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211 results on '"Jackson, James"'

10. Is prospective MRI mapping of the changes in the volume of the prostate gland in prostate cancer patients undergoing 6 months of neo‐adjuvant androgen deprivation therapy a step towards a trial to determine those who may benefit from treatment intensification or extended duration?

Author

Christie, David RH, primary, Sharpley, Christopher F, additional, Mitina, Natalia, additional, MacAteer, Eamonn, additional, Jackson, James E, additional, and Lunn, Dominic, additional

Published
2020
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15. Developmental wave of Brn3b expression leading to RGC fate specification is synergistically maintained by miR-23a and miR-374

Author

Jackson James, Vazhanthodi Abdul Rasheed, Sivadasan Bindu Dhanesh, Thulasi Sheela Divya, Palakkottu K. Akhila, Sreekumaran Sreekanth, K Sivakumar, Chandramohan Subashini, Mundackal Sivaraman Divya, and Ani V. Das

Subjects
Retina, Retinal, Histogenesis, Biology, Cell fate determination, Cellular and Molecular Neuroscience, chemistry.chemical_compound, medicine.anatomical_structure, Developmental Neuroscience, Retinal ganglion cell, chemistry, microRNA, medicine, Axon guidance, sense organs, Neuroscience, Ganglion cell layer
Abstract

Differential regulation of Brn3b is essential for the Retinal Ganglion Cell (RGC) development in the two phases of retinal histogenesis. This biphasic Brn3b regulation is required first, during early retinal histogenesis for RGC fate specification and secondly, during late histogenesis, where Brn3b is needed for RGC axon guidance and survival. Here, we have looked into how the regulation of Brn3b at these two stages happens. We identified two miRNAs, miR-23a and miR-374, as regulators of Brn3b expression, during the early stage of RGC development. Temporal expression pattern of miR-23a during E10–19, PN1–7, and adult retina revealed an inverse relation with Brn3b expression. Though miR-374 did not show such a pattern, its co-expression with miR-23a evidently inhibited Brn3b. We further substantiated these findings by ex vivo overexpression of these miRNAs in E14 mice retina and found that miR-23a and miR-374 together brings about a change in Brn3b expression pattern in ganglion cell layer (GCL) of the developing retina. From our results, it appears that the combined expression of these miRNAs could be regulating the timing of the wave of Brn3b expression required for early ganglion cell fate specification and later for its survival and maturation into RGCs. Taken together, here we provide convincing evidences for the existence of a co-ordinated mechanism by miRNAs to down regulate Brn3b that will ultimately regulate the development of RGCs from their precursors. © 2014 Wiley Periodicals, Inc. Develop Neurobiol 74: 1155–1171, 2014

Published
2014

16. AHNS Series: Do you know your guidelines? Optimizing outcomes in reoperative parathyroid surgery: Definitive multidisciplinary joint consensus guidelines of the American Head and Neck Society and the British Association of Endocrine and Thyroid Surgeons

Author

Stack, Brendan C., primary, Tolley, Neil S., additional, Bartel, Twyla B., additional, Bilezikian, John P., additional, Bodenner, Donald, additional, Camacho, Pauline, additional, Cox, Jeremy P. D. T., additional, Dralle, Henning, additional, Jackson, James E., additional, Morris, John C., additional, Orloff, Lisa Ann, additional, Palazzo, Fausto, additional, Ridge, John A., additional, Scott-Coombes, David, additional, Steward, David, additional, Terris, David J., additional, Thompson, Geoffrey, additional, and Randolph, Gregory W., additional

Published
2018
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17. Pretreatment risk stratification of feeding tube use in patients treated with intensity‐modulated radiotherapy for head and neck cancer

Author

Anderson, Nigel J., primary, Jackson, James E., additional, Smith, Jennifer G., additional, Wada, Morikatsu, additional, Schneider, Michal, additional, Poulsen, Michael, additional, Rolfo, Maureen, additional, Fahandej, Maziar, additional, Gan, Hui, additional, Joon, Daryl Lim, additional, and Khoo, Vincent, additional

Published
2018
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20. Pilocarpine-loaded poly(DL-lactic-co-glycolic acid) nanoparticles as potential candidates for controlled drug delivery with enhanced ocular pharmacological response

Author

G. S. Vinod Kumar, Sasidharan Vidyanand, Jackson James, and K. Lekha Nair

Subjects
Miosis, Materials science, Polymers and Plastics, Alkaloid, Nanoparticle, General Chemistry, Pharmacology, Surfaces, Coatings and Films, chemistry.chemical_compound, PLGA, chemistry, Pilocarpine, In vivo, Drug delivery, Materials Chemistry, medicine, medicine.symptom, Glycolic acid, medicine.drug
Abstract

The poor corneal residence time of pilocarpine, an alkaloid extracted from the leaves of the Jaborandi plant, limits its ocular application. The aim of this study was to develop, characterize, and evaluate the potential of pilocarpine entrapped by poly(DL-lactic-co-glycolic acid) (PLGA) nanoparticle carriers for ocular drug delivery. Pilocarpine-loaded nanoparticles were prepared with a double-emulsion (water in oil in water) method and characterized with transmission electron microscopy and X-ray diffraction analysis. The nanoparticles exhibited an average size of 82.7 nm with an encapsulation efficiency of 57%. Stability studies showed the absence of agglomeration and constancy in the amount of drug entrapped; this indicated the solidity of these particles for long-term use. The in vitro release studies conducted in simulated tear fluid showed the sustained release of pilocarpine. In vivo evaluation of the nanoparticles was done in a rabbit model with a miosis assay and compared to an equal dose of commercially available eye drops of pilocarpine (Pilocar drops). The in vivo miosis studies showed that the duration of miotic response increased by 40% for the nanoparticles and produced an almost 68% increase in total miotic response when compared to the eye drops. In conclusion, this study clearly demonstrated the potential of pilocarpine-loaded PLGA nanoparticles for multiplying the therapeutic effect of ophthalmic drug delivery with enhanced bioavailability and pharmacological response. © 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2012

Published
2011

25. Cellular and molecular characterization of early and late retinal stem cells/progenitors: Differential regulation of proliferation and context dependent role of Notch signaling

Author

Ani V. Das, Jackson James, Jörg Rahnenführer, and Iqbal Ahmad

Subjects
Retina, General Neuroscience, Notch signaling pathway, Stem cell factor, Biology, Fibroblast growth factor, Cell biology, Cellular and Molecular Neuroscience, medicine.anatomical_structure, Epidermal growth factor, Neurosphere, medicine, Progenitor cell, Stem cell
Abstract

Retinal stem cells/progenitors that define the evolutionarily conserved early and late stages of retinal histogenesis are known to have distinct competence to give rise to stage-specific retinal cell types. However, the information regarding their innate proliferative behavior and phenotypic potential in terms of generating neurons and glia is lacking. Here we demonstrate that, like their counterparts in other central nervous system (CNS) regions during early and late stages of embryonic development, the early and late retinal stem cells/progenitors display different proliferative response to fibroblast growth factor 2 (FGF2) and epidermal growth factor (EGF) and bias towards generating neurons or glia. Although the former predominantly generate neurons, the latter are partial towards giving rise to glia. Transcription profiling identified classes of genes that are differentially expressed in early and late retinal stem cells/progenitors in proliferating conditions and suggested that the distinct proliferative response to FGF2 and EGF is likely due to differential expression of FGF receptor 1 (FGFR1) and EGF receptor (EGFR). However, the proliferative maintenance of retinal stem cells/progenitors is likely to include other signaling pathways such as those mediated by insulin-like growth factors (IGFs) and stem cell factor (SCF). Transcription profiling of early and late retinal stem cells/progenitors in proliferating and differentiating conditions suggested a context dependent role for Notch signaling, which may constitute one of the mechanisms underlying the stage-dependent phenotypic potential of retinal stem cells/progenitors. © 2004 Wiley Periodicals, Inc. J Neurobiol, 2004

Published
2004

26. Involvement of numb in vertebrate retinal development: Evidence for multiple roles of numb in neural differentiation and maturation

Author

Iqbal Ahmad, Jackson James, Constance M. Dooley, and C. Jane McGlade

Subjects
animal structures, Blotting, Western, Molecular Sequence Data, Notch signaling pathway, Fluorescent Antibody Technique, Cell Communication, Biology, Cell fate determination, Retina, Rats, Sprague-Dawley, Embryonic and Fetal Development, Cellular and Molecular Neuroscience, Tubulin, Lateral inhibition, Morphogenesis, medicine, Animals, Drosophila Proteins, Protein Isoforms, Mitosis, Cells, Cultured, Cellular Senescence, Neurons, Receptors, Notch, Reverse Transcriptase Polymerase Chain Reaction, General Neuroscience, fungi, Neurogenesis, Membrane Proteins, Cell Differentiation, Cell cycle, Embryo, Mammalian, Rats, Juvenile Hormones, Alternative Splicing, medicine.anatomical_structure, embryonic structures, NUMB, Neuroscience, hormones, hormone substitutes, and hormone antagonists, Signal Transduction
Abstract

Cell fate specification is regulated in part by lateral inhibition mediated by Notch signaling. Notch signaling is negatively regulated by Numb, an intrinsic factor that regulates cellular competence. In this study we have examined the involvement of Numb in retinal development, which has been shown to be influenced by Notch signaling. In the developing retina, Numb is asymmetrically distributed towards the ventricular and vitreal poles of different cells. Asymmetric localization is evident not only in mitotic cells but in postmitotic ganglion cells as well, suggesting that the subcellular distribution of Numb may play a role after cells have exited the cell cycle. This is supported by the expression of Numb in terminally differentiated neurons in the adult retina. Although Numb is an intrinsic factor, it is observed that its subcellular distribution is influenced by epigenetic cues such that a higher proportion of cells cultured at high density express Numb asymmetrically. A correlation is observed between asymmetric localization and cellular competence; cells in which Numb is asymmetric differentiate more readily in culture than those that express Numb symmetrically. We have identified alternative splice variants in the developing and adult retina that correspond to isoforms that have been shown to regulate proliferation and differentiation. The dynamic temporal expression patterns of alternative splice variants and isoforms suggest that Numb may influence proliferation and differentiation of retinal progenitors during neurogenesis and maturation of postmitotic neurons. Together, these results demonstrate the complex role of the distribution of Numb within progenitors and postmitotic neurons.

Published
2002

45. Impact of Evidence‐Based Standardized Assessment on the Disability Clinical Interview for Diagnosis of Service‐Connected PTSD: A Cluster‐Randomized Trial

Author

Speroff, Theodore, primary, Sinnott, Patricia L., additional, Marx, Brian, additional, Owen, Richard R., additional, Jackson, James C., additional, Greevy, Robert, additional, Sayer, Nina, additional, Murdoch, Maureen, additional, Shane, Andrea C., additional, Smith, Jeffrey, additional, Alvarez, JoAnn, additional, Nwosu, Samuel K., additional, Keane, Terence, additional, Weathers, Frank, additional, Schnurr, Paula P., additional, and Friedman, Matthew J., additional

Published
2012
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