1. Parents know it best: Prediction of asthma and lung function by parental perception of early wheezing episodes
- Author
-
Amandine Divaret-Chauveau, Anne M. Karvonen, Markus J. Ege, Juha Pekkanen, Alexander J. Hose, Jean-Charles Dalphin, Josef Riedler, Roger Lauener, Katharina Wawretzka, Tabea Brick, Caroline Roduit, Erika von Mutius, Department of Public Health, University of Helsinki, Department of Dermatology, Allergology and Venereology, and Clinicum
- Subjects
Male ,Parents ,Rural Population ,Pediatrics ,CHILDREN ,Cohort Studies ,early wheeze ,asthma risk ,0302 clinical medicine ,3123 Gynaecology and paediatrics ,Surveys and Questionnaires ,Recall bias ,Prevalence ,Immunology and Allergy ,Prospective Studies ,030212 general & internal medicine ,Child ,Lung function ,2. Zero hunger ,chromosome 17q21 ,Asthma Risk ,Childhood Asthma ,Chromosome 17q21 ,Early Wheeze ,Genetic Asthma Risk ,Parental Wheeze Recall ,ASSOCIATION ,Prognosis ,Europe ,genetic asthma risk ,INFECTIONS ,ATOPY ,Child, Preschool ,Female ,medicine.symptom ,medicine.medical_specialty ,parental wheeze recall ,Immunology ,PHENOTYPES ,1ST-YEAR ,DIAGNOSIS ,EARLY-LIFE ,03 medical and health sciences ,Wheeze ,medicine ,Humans ,Clinical significance ,Respiratory Sounds ,Retrospective Studies ,Asthma ,Recall ,business.industry ,Infant, Newborn ,CHILDHOOD ASTHMA ,Infant ,Odds ratio ,medicine.disease ,Confidence interval ,respiratory tract diseases ,030228 respiratory system ,3121 General medicine, internal medicine and other clinical medicine ,Pediatrics, Perinatology and Child Health ,RISK-FACTORS ,Perception ,business ,Follow-Up Studies - Abstract
Background: Childhood asthma is often preceded by early wheeze. Usually, wheezing episodes are recorded retrospectively, which may induce recall bias. Aims and objectives: The aim of this study was to investigate true-positive recall of parent-reported wheeze at 1year of age, its determinants, and its implications for asthma and lung function at 6years of age. Methods: The PASTURE (Protection Against Allergy—Study in Rural Environments) study followed 880 children from rural areas in 5 European countries from birth to age 6years. Wheeze symptoms in the first year were asked weekly. At age 6, parent-reported asthma diagnosis was ascertained and lung function measurements were conducted. Correct parental recall of wheeze episodes at the end of the first year was assessed for associations with lung function, asthma, and the asthma risk locus on chromosome 17q21. Results: Parents correctly recalled wheeze after the first year in 54% of wheezers. This true-positive recall was determined by number of episodes, timing of the last wheeze episode, and parental asthma. Independently from these determinants, true-positive recall predicted asthma at age 6years (odds ratio 4.54, 95% confidence interval (CI) [1.75-14.16]) and impaired lung function (β=−0.62, 95% CI [−1.12; −0.13], P-value=.02). Associations were stronger in children with asthma risk SNPs on chromosome 17q21. Conclusion: Correct parental recall of wheezing episodes may reflect clinical relevance of early wheeze and its impact on subsequent asthma and lung function impairment. Questions tailored to parental perception of wheezing episodes may further enhance asthma prediction.
- Published
- 2019