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1. Myocardial perfusion in cardiac amyloidosis

Author

Chacko, Liza, primary, Kotecha, Tushar, additional, Ioannou, Adam, additional, Patel, Niket, additional, Martinez‐Naharro, Ana, additional, Razvi, Yousuf, additional, Patel, Rishi, additional, Massa, Paolo, additional, Venneri, Lucia, additional, Brown, James, additional, Porcari, Aldostefano, additional, Knott, Kristopher, additional, Manisty, Charlotte, additional, Knight, Daniel, additional, Lockie, Tim, additional, Rakhit, Roby, additional, Lachmann, Helen, additional, Wechelakar, Ashutosh, additional, Whelan, Carol, additional, Ponticos, Markella, additional, Moon, James, additional, González, Arantxa, additional, Gilbertson, Janet, additional, Riefolo, Mattia, additional, Leone, Ornella, additional, Xue, Hui, additional, Hawkins, Philip, additional, Kellman, Peter, additional, Gillmore, Julian, additional, and Fontana, Marianna, additional

Published
2024
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2. Albuminuria in cardiac ATTR amyloidosis: prevalence, progression and prognostic importance

Author

Ioannou, Adam, primary, Rauf, Muhammad U, additional, Patel, Rishi K, additional, Razvi, Yousuf, additional, Porcari, Aldostefano, additional, Martinez‐Naharro, Ana, additional, Venneri, Lucia, additional, Bandera, Francesco, additional, Virsinskaite, Ruta, additional, Kotecha, Tushar, additional, Knight, Dan, additional, Petrie, Aviva, additional, Whelan, Carol, additional, Wechalekar, Ashutosh, additional, Lachmann, Helen, additional, Hawkins, Philip N, additional, Solomon, Scott D, additional, Gillmore, Julian D, additional, and Fontana, Marianna, additional

Published
2023
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3. Deep phenotyping of p.(V142I)‐associated variant ATTR amyloid cardiomyopathy: distinct from wild‐type ATTR amyloidosis?

Author

Razvi, Yousuf, primary, Ioannou, Adam, additional, Patel, Rishi K, additional, Chacko, Liza, additional, Karia, Nina, additional, Riefolo, Mattia, additional, Porcari, Aldostefano, additional, Rauf, Muhammad Umaid, additional, Starr, Neasa, additional, Ganesananthan, Sashiananthan, additional, Blakeney, Iona, additional, Kaza, Nandita, additional, Filisetti, Stefano, additional, Bolhuis, Roos Eline, additional, Rowczenio, Dorota, additional, Gilbertson, Janet, additional, Hutt, David, additional, Mahmood, Shameem, additional, Lachmann, Helen J, additional, Wechalekar, Ashutosh D, additional, Kotecha, Tushar, additional, Knight, Daniel S, additional, Coghlan, John G, additional, Petrie, Aviva, additional, Whelan, Carol J, additional, Venneri, Lucia, additional, Martinez‐Naharro, Ana, additional, Hawkins, Phillip, additional, Fontana, Marianna, additional, and Gillmore, Julian D, additional

Published
2023
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5. Prevalence, characteristics and outcomes of older patients with hereditary versus wild‐type transthyretin amyloid cardiomyopathy

Author

Porcari, Aldostefano, primary, Razvi, Yousuf, additional, Masi, Ambra, additional, Patel, Rishi, additional, Ioannou, Adam, additional, Rauf, Muhammad U., additional, Hutt, David F., additional, Rowczenio, Dorota, additional, Gilbertson, Janet, additional, Martinez‐Naharro, Ana, additional, Venneri, Lucia, additional, Whelan, Carol, additional, Lachmann, Helen, additional, Wechalekar, Ashutosh, additional, Quarta, Candida Cristina, additional, Merlo, Marco, additional, Sinagra, Gianfranco, additional, Hawkins, Philip N., additional, Fontana, Marianna, additional, and Gillmore, Julian D., additional

Published
2023
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6. Sex differences among patients with transthyretin amyloid cardiomyopathy – from diagnosis to prognosis

Author

Patel, Rishi K., primary, Ioannou, Adam, additional, Razvi, Yousuf, additional, Chacko, Liza, additional, Venneri, Lucia, additional, Bandera, Francesco, additional, Knight, Daniel, additional, Kotecha, Tushar, additional, Martinez‐Naharro, Ana, additional, Masi, Ambra, additional, Porcari, Aldostefano, additional, Brown, James, additional, Patel, Kiara, additional, Manisty, Charlotte, additional, Moon, James, additional, Rowczenio, Dorota, additional, Gilbertson, Janet A., additional, Sinagra, Gianfranco, additional, Lachmann, Helen, additional, Wechalekar, Ashutosh, additional, Petrie, Aviva, additional, Whelan, Carol, additional, Hawkins, Philip N., additional, Gillmore, Julian D., additional, and Fontana, Marianna, additional

Published
2022
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7. Progression of echocardiographic parameters and prognosis in transthyretin cardiac amyloidosis

Author

Chacko, Liza, primary, Karia, Nina, additional, Venneri, Lucia, additional, Bandera, Francesco, additional, Passo, Beatrice Dal, additional, Buonamici, Lodovico, additional, Lazari, Jonathan, additional, Ioannou, Adam, additional, Porcari, Aldostefano, additional, Patel, Rishi, additional, Razvi, Yousuf, additional, Brown, James, additional, Knight, Daniel, additional, Martinez‐Naharro, Ana, additional, Whelan, Carol, additional, Quarta, Candida C., additional, Manisty, Charlotte, additional, Moon, James, additional, Rowczenio, Dorota, additional, Gilbertson, Janet A., additional, Lachmann, Helen, additional, Wechelakar, Ashutosh, additional, Petrie, Aviva, additional, Moody, William E., additional, Steeds, Richard P., additional, Potena, Luciano, additional, Riefolo, Mattia, additional, Leone, Ornella, additional, Rapezzi, Claudio, additional, Hawkins, Philip N., additional, Gillmore, Julian D., additional, and Fontana, Marianna, additional

Published
2022
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10. External electrical and pharmacological cardioversion for atrial fibrillation, atrial flutter or atrial tachycardias: a network meta-analysis

Author

Providencia, Rui, primary, Chew, Derek, additional, Taylor, Julie, additional, Kukendra-Rajah, Kishore, additional, Papageorgiou, Nikolaos, additional, Ioannou, Adam, additional, Mead, Gillian E, additional, Nevis, Immaculate IF, additional, Wilton, Stephen B, additional, Lambiase, Pier, additional, and Morillo, Carlos A, additional

Published
2019
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11. Interrupted versus uninterrupted novel oral anticoagulant peri-implantation of cardiac device: A single-center randomized prospective pilot trial

Author

Ricciardi, Danilo, primary, Creta, Antonio, additional, Colaiori, Iginio, additional, Scordino, Domenico, additional, Ragni, Laura, additional, Picarelli, Francesco, additional, Calabrese, Vito, additional, Providência, Rui, additional, Ioannou, Adam, additional, and Di Sciascio, Germano, additional

Published
2018
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12. Dual-site right ventricular pacing in patients undergoing cardiac resynchronization therapy: Results of a multicenter propensity-matched analysis

Author

Providencia, Rui, primary, Barra, Sergio, additional, Papageorgiou, Nikolaos, additional, Ioannou, Adam, additional, Rogers, Dominic, additional, Wongwarawipat, Tanakal, additional, Falconer, Debbie, additional, Duehmke, Rudolf, additional, Colicchia, Martina, additional, Babu, Girish, additional, Segal, Oliver R., additional, Sporton, Simon, additional, Dhinoja, Mehul, additional, Ahsan, Syed, additional, Ezzat, Vivienne, additional, Rowland, Edward, additional, Lowe, Martin, additional, Lambiase, Pier D., additional, Agarwal, Sharad, additional, and Chow, Anthony W., additional

Published
2017
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13. Sex differences among patients with transthyretin amyloid cardiomyopathy – from diagnosis to prognosis

Author

Rishi K. Patel, Adam Ioannou, Yousuf Razvi, Liza Chacko, Lucia Venneri, Francesco Bandera, Daniel Knight, Tushar Kotecha, Ana Martinez‐Naharro, Ambra Masi, Aldostefano Porcari, James Brown, Kiara Patel, Charlotte Manisty, James Moon, Dorota Rowczenio, Janet A. Gilbertson, Gianfranco Sinagra, Helen Lachmann, Ashutosh Wechalekar, Aviva Petrie, Carol Whelan, Philip N. Hawkins, Julian D. Gillmore, Marianna Fontana, Patel, Rishi K., Ioannou, Adam, Razvi, Yousuf, Chacko, Liza, Venneri, Lucia, Bandera, Francesco, Knight, Daniel, Kotecha, Tushar, Martinez-Naharro, Ana, Masi, Ambra, Porcari, Aldostefano, Brown, Jame, Patel, Kiara, Manisty, Charlotte, Moon, Jame, Rowczenio, Dorota, Gilbertson, Janet A., Sinagra, Gianfranco, Lachmann, Helen, Wechalekar, Ashutosh, Petrie, Aviva, Whelan, Carol, Hawkins, Philip N., Gillmore, Julian D., and Fontana, Marianna

Subjects
Male, Heart Failure, Amyloid Neuropathies, Familial, Sex Characteristics, diagnosis, Amyloidosis, Prognosis, echocardiography, sex, prognosis, diagnosi, Disease Progression, Amyloidosi, Humans, Prealbumin, Female, Cardiomyopathies, Cardiology and Cardiovascular Medicine
Abstract

Aims: transthyretin amyloid cardiomyopathy (ATTR-CM) is predominantly diagnosed in men. The few available studies suggest affected women have a more favourable cardiac phenotype. We aimed to characterize sex differences among consecutive patients with non-hereditary and two prevalent forms of hereditary (h)ATTR-CM diagnosed over a 20-year period. Methods and results: analysis of deep phenotyping at presentation, changes on serial echocardiography and overall prognosis were evaluated. In total, 1732 consecutive patients were studied, comprising: 1095 with wild-type (wt)ATTR-CM; 206 with T60A-hATTR-CM; and 431 with V122I-hATTR-CM. Female prevalence was greater in T60A-hATTR-CM (29.6%) and V122I-hATTR-CM (27.8%) compared to wtATTR-CM (6%). At presentation, females were 3.3 years older than males (wtATTR-CM: 81.9 vs. 77.8 years; T60A-hATTR-CM: 68.7 vs. 65.1 years; V122I-hATTR-CM: 77.1 vs. 74.9 years). Body size significantly influenced measures of disease severity; when indexed, overall structural and functional phenotype was similar between sexes, the few significant differences suggested a mildly worse phenotype in females. No significant differences were observed in both disease progression on serial echocardiography and mortality across the overall population (p = 0.459) and when divided by genotype (wtATTR-CM: p = 0.730; T60A-hATTR-CM: p = 0.161; V122I-hATTR-CM: p = 0.056). Conclusion: this study of a well-characterized large cohort of ATTR-CM patients did not demonstrate overall differences between sexes in either clinical phenotype, when indexed, or with respect to disease progression and prognosis. Non-indexed wall thickness measurements may have contributed to both under-representation and delays in diagnosis for affected females and highlights the potential role of utilizing indexed echocardiographic parameters for a more accurate assessment of patients at diagnosis and for disease prognostication.

Published
2022
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