1. High dose intravenous gammaglobulin and platelet transfusions in leukaemic HLA-immunized patients
- Author
-
N. Duedari, P. Bierling, Catherine Cordonnier, Jean-Paul Vernant, M. Rodet, A. Pesce, and Henri Rochant
- Subjects
Adult ,Blood Platelets ,Male ,Cell Survival ,Dose-Response Relationship, Immunologic ,Platelet Transfusion ,Human leukocyte antigen ,Refractory ,HLA Antigens ,Isoantibodies ,Pregnancy ,hemic and lymphatic diseases ,Humans ,Medicine ,Blood Transfusion ,Hla antibodies ,Platelet ,Platelet recovery ,business.industry ,Intravenous gammaglobulin ,Gamma globulin ,Hematology ,Acute leukaemias ,Leukemia, Myeloid, Acute ,Injections, Intravenous ,Immunology ,Female ,Immunization ,gamma-Globulins ,business - Abstract
3 aplastic patients with acute leukaemia, strongly HLA-immunized and refractory to platelet transfusions, received polyvalent gammaglobulin i.v. infusions (0.4 g/kg/d for 5 or 6 d) in association with daily random platelet transfusions. Platelet recovery was obtained in 2 patients. The 3rd patient did not show any significant rise in platelet count. The ability of gammaglobulin to prolong the life-span of incompatible transfused platelets could facilitate the management of HLA-immunized patients.
- Published
- 2009