1. Maternal characteristics and pregnancy outcomes of hospitalized pregnant women with SARS‐CoV‐2 infection in South Africa: An International Network of Obstetric Survey Systems‐based cohort study
- Author
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Chantal Stewart, Eduard Langenegger, Nnabuike Chibuoke Ngene, Priya Soma-Pillay, Gregory Petro, Serantha Foolchand, Hennie Lombaard, Ahminah Fakier, Mala Panday, Amy Wise, Liesl de Waard, Shastra Bhoora, Priya Israel, Logie Govender, Charlene Maistry, Felicia Molokoane, Lawrence Chauke, Nondumiso Ngxola, Salome Maswime, Mzuvele Hlabisa, Nomandla V Tsibiyane, Keshree Naidoo, Samantha Budhram, Emma Wynne, Unati Mbewu, Catherine Cluver, Mama-Asu Koranteng-Peprah, Mushi Matjila, Mfundo Mabenge, Elizabeth J. van Rensburg, Chrysanthi Georgiou, Gaynor M Balie, Ayesha Osman, Adrie Bekker, Matthew S Mojela, John P Habineza, Sylvia N. Cebekhulu, Tshililo Mashamba, Tanita Botha, Sue Fawcus, Mareli Venter, Sumaiya Adam, Natalie Odell, Santhi Venkatachalam, Sean Mould, Valerie Vannevel, Laura M Yates, Sudhir Prithipal, Gareth Goldman, Kay Tunkyi, Siva Moodley, Terence Moodley, Sibusiso Phinzi, Emmanuel M C Ati, Nontsikelelo Gubu-Ntaba, and Ongombe Lunda
- Subjects
education.field_of_study ,medicine.medical_specialty ,International network ,Tuberculosis ,business.industry ,Obstetrics ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,Population ,Obstetrics and Gynecology ,General Medicine ,medicine.disease ,Case fatality rate ,Health care ,Medicine ,business ,education ,Pregnancy outcomes ,Cohort study - Abstract
OBJECTIVE: To describe risk factors and outcomes of pregnant women infected with SARS-CoV-2 admitted to South African healthcare facilities. METHODS: A population-based cohort study was conducted utilizing an amended International Obstetric Surveillance System protocol. Data on pregnant women with SARS-CoV-2 infection, hospitalized between April 14, 2020, and November 24, 2020, were analyzed. RESULTS: A total of 36 hospitals submitted data on 673 infected hospitalized pregnant women; 217 (32.2%) were admitted for COVID-19 illness and 456 for other indications. There were 39 deaths with a case fatality rate of 6.3%: 32 (14.7%) deaths occurred in women admitted for COVID-19 illness compared to 7 (1.8%) in women admitted for other indications. Of the women, 106 (15.9%) required critical care. Maternal tuberculosis, but not HIV co-infection or other co-morbidities, was associated with admission for COVID-19 illness. Rates of cesarean delivery did not differ significantly between women admitted for COVID-19 and those admitted for other indications. There were 179 (35.4%) preterm births, 25 (4.7%) stillbirths, 12 (2.3%) neonatal deaths, and 162 (30.8%) neonatal admissions. Neonatal outcomes did not differ significantly from those of infected women admitted for other indications. CONCLUSION: The maternal mortality rate was high among women admitted with SARS-CoV-2 infection and higher in women admitted primarily for COVID-19 illness with tuberculosis being the only co-morbidity associated with admission.
- Published
- 2021