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27 results on '"IACOVIELLO, MASSIMO"'

1. Pharmacoutilization and adherence to sacubitril/valsartan in real world: the REAL.IT study in HFrEF

Author

Iacoviello, Massimo, primary, Di Gesaro, Gabriele, additional, Sarullo, Filippo Maria, additional, Miani, Daniela, additional, Driussi, Mauro, additional, Correale, Michele, additional, Bilato, Claudio, additional, Passantino, Andrea, additional, Carluccio, Erberto, additional, Villani, Alessandra, additional, degli Esposti, Luca, additional, d'Agostino, Chiara, additional, Peruzzi, Elena, additional, Poli, Simone, additional, and di Lenarda, Andrea, additional

Published
2023
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2. Atrial paced rhythm and heart rate‐dependent worsening of left atrial and ventricular function

Author

Corbo, Maria Delia, primary, Terlizzi, Vito di, additional, Barone, Roberta, additional, Pellegrino, Pierluigi, additional, Goffredo, Giovanni, additional, Pugliese, Rosanna, additional, Correale, Michele, additional, Ieva, Riccardo, additional, Di Biase, Matteo, additional, Brunetti, Natale Daniele, additional, and Iacoviello, Massimo, additional

Published
2023
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3. Near zero vascular complications using echo‐guided puncture during catheter ablation of arrhythmias: A retrospective study and literature review

Author

Pellegrino, Pier Luigi, primary, Di Monaco, Antonio, additional, Santoro, Francesco, additional, Grimaldi, Massimo, additional, D'Arienzo, Girolamo, additional, Casavecchia, Grazia, additional, Ieva, Riccardo, additional, Di Biase, Matteo, additional, Iacoviello, Massimo, additional, and Brunetti, Natale Daniele, additional

Published
2022
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6. Renal effects of guideline‐directed medical therapies in heart failure: a consensus document from the Heart Failure Association of the European Society of Cardiology

Author

Mullens, Wilfried, primary, Martens, Pieter, additional, Testani, Jeffrey M., additional, Tang, W.H. Wilson, additional, Skouri, Hadi, additional, Verbrugge, Frederik H., additional, Fudim, Marat, additional, Iacoviello, Massimo, additional, Franke, Jennifer, additional, Flammer, Andreas J., additional, Palazzuoli, Alberto, additional, Barragan, Paola Morejon, additional, Thum, Thomas, additional, Marcos, Marta Cobo, additional, Miró, Òscar, additional, Rossignol, Patrick, additional, Metra, Marco, additional, Lassus, Johan, additional, Orso, Francesco, additional, Jankowska, Ewa A., additional, Chioncel, Ovidiu, additional, Milicic, Davor, additional, Hill, Loreena, additional, Seferovic, Petar, additional, Rosano, Giuseppe, additional, Coats, Andrew, additional, and Damman, Kevin, additional

Published
2022
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7. Pathophysiology of Takotsubo syndrome – a joint scientific statement from the Heart Failure Association Takotsubo Syndrome Study Group and Myocardial Function Working Group of the European Society of Cardiology – Part 1: overview and the central role for catecholamines and sympathetic nervous system

Author

Omerovic, Elmir, primary, Citro, Rodolfo, additional, Bossone, Eduardo, additional, Redfors, Bjorn, additional, Backs, Johannes, additional, Bruns, Bastian, additional, Ciccarelli, Michele, additional, Couch, Liam S., additional, Dawson, Dana, additional, Grassi, Guido, additional, Iacoviello, Massimo, additional, Parodi, Guido, additional, Schneider, Birke, additional, Templin, Christian, additional, Ghadri, Jelena R., additional, Thum, Thomas, additional, Chioncel, Ovidiu, additional, Tocchetti, C. Gabriele, additional, van der Velden, Jolanda, additional, Heymans, Stephane, additional, and Lyon, Alexander R., additional

Published
2022
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8. Pathophysiology of Takotsubo syndrome – a joint scientific statement from the Heart Failure Association Takotsubo Syndrome Study Group and Myocardial Function Working Group of the European Society of Cardiology – Part 2: vascular pathophysiology, gender and sex hormones, genetics, chronic cardiovascular problems and clinical implications

Author

Omerovic, Elmir, primary, Citro, Rodolfo, additional, Bossone, Eduardo, additional, Redfors, Bjorn, additional, Backs, Johannes, additional, Bruns, Bastian, additional, Ciccarelli, Michele, additional, Couch, Liam S., additional, Dawson, Dana, additional, Grassi, Guido, additional, Iacoviello, Massimo, additional, Parodi, Guido, additional, Schneider, Birke, additional, Templin, Christian, additional, Ghadri, Jelena R., additional, Thum, Thomas, additional, Chioncel, Ovidiu, additional, Tocchetti, C. Gabriele, additional, van der Velden, Jolanda, additional, Heymans, Stephane, additional, and Lyon, Alexander R., additional

Published
2021
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11. Eligibility of outpatients with chronic heart failure for sodium–glucose co‐transporter‐2 inhibitors

Author

Angelini, Gianmarco, primary, Albanese, Miriam, additional, Ursi, Raffaella, additional, Lisi, Francesco, additional, Bellino, Maria Consiglia, additional, Amato, Luca, additional, Gioia, Margherita Ilaria, additional, Parisi, Giuseppe, additional, Brunetti, Natale Daniele, additional, Piazzolla, Giuseppina, additional, Ciccone, Marco Matteo, additional, and Iacoviello, Massimo, additional

Published
2021
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14. Heart and brain interaction in patients with heart failure: overview and proposal for a taxonomy. A position paper from the Study Group on Heart and Brain Interaction of the Heart Failure Association

Author

Doehner, Wolfram, primary, Ural, Dilek, additional, Haeusler, Karl Georg, additional, Čelutkienė, Jelena, additional, Bestetti, Reinaldo, additional, Cavusoglu, Yuksel, additional, Peña-Duque, Marco A., additional, Glavas, Duska, additional, Iacoviello, Massimo, additional, Laufs, Ulrich, additional, Alvear, Ricardo Marmol, additional, Mbakwem, Amam, additional, Piepoli, Massimo F., additional, Rosen, Stuart D., additional, Tsivgoulis, Georgios, additional, Vitale, Cristiana, additional, Yilmaz, M. Birhan, additional, Anker, Stefan D., additional, Filippatos, Gerasimos, additional, Seferovic, Petar, additional, Coats, Andrew J.S., additional, and Ruschitzka, Frank, additional

Published
2017
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15. Continuing Medical Education activity inEchocardiographyJuly 2016

Author

Iacoviello, Massimo, additional, Citarelli, Gaetano, additional, Antoncecchi, Valeria, additional, Romito, Roberta, additional, Monitillo, Francesco, additional, Leone, Marta, additional, Puzzovivo, Agata, additional, Lattarulo, Maria Silvia, additional, Rizzo, Caterina, additional, Caldarola, Pasquale, additional, and Ciccone, Marco Matteo, additional

Published
2016
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16. Right Ventricular Longitudinal Strain Measures Independently Predict Chronic Heart Failure Mortality

Author

Iacoviello, Massimo, primary, Citarelli, Gaetano, additional, Antoncecchi, Valeria, additional, Romito, Roberta, additional, Monitillo, Francesco, additional, Leone, Marta, additional, Puzzovivo, Agata, additional, Lattarulo, Maria Silvia, additional, Rizzo, Caterina, additional, Caldarola, Pasquale, additional, and Ciccone, Marco Matteo, additional

Published
2016
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17. The renal arterial resistance index: a marker of renal function with an independent and incremental role in predicting heart failure progression

Author

Ciccone, Marco Matteo, primary, Iacoviello, Massimo, additional, Gesualdo, Loreto, additional, Puzzovivo, Agata, additional, Antoncecchi, Valeria, additional, Doronzo, Annalisa, additional, Monitillo, Francesco, additional, Citarelli, Gaetano, additional, Paradies, Valeria, additional, and Favale, Stefano, additional

Published
2013
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21. Prognostic value of brain natriuretic peptide in the management of patients receiving cardiac resynchronization therapy

Author

Pitzalis, Maria Vittoria, primary, Iacoviello, Massimo, additional, Di Serio, Francesca, additional, Romito, Roberta, additional, Guida, Pietro, additional, De Tommasi, Elisabetta, additional, Luzzi, Giovanni, additional, Anaclerio, Matteo, additional, Varraso, Lucia, additional, Forleo, Cinzia, additional, and Pansini, Nicola, additional

Published
2006
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23. Pathophysiology of Takotsubo syndrome - a joint scientific statement from the Heart Failure Association Takotsubo Syndrome Study Group and Myocardial Function Working Group of the European Society of Cardiology - Part 1: overview and the central role for catecholamines and sympathetic nervous system

Author

Elmir, Omerovic, Rodolfo, Citro, Eduardo, Bossone, Bjorn, Redfors, Johannes, Backs, Bastian, Bruns, Michele, Ciccarelli, Liam S, Couch, Dana, Dawson, Guido, Grassi, Massimo, Iacoviello, Guido, Parodi, Birke, Schneider, Christian, Templin, Jelena R, Ghadri, Thomas, Thum, Ovidiu, Chioncel, C Gabriele, Tocchetti, Jolanda, van der Velden, Stephane, Heymans, Alexander R, Lyon, Omerovic, Elmir, Citro, Rodolfo, Bossone, Eduardo, Redfors, Bjorn, Backs, Johanne, Bruns, Bastian, Ciccarelli, Michele, Couch, Liam S, Dawson, Dana, Grassi, Guido, Iacoviello, Massimo, Parodi, Guido, Schneider, Birke, Templin, Christian, Ghadri, Jelena R, Thum, Thoma, Chioncel, Ovidiu, Tocchetti, Carlo Gabriele, Van Der Velden, Jolanda, Heymans, Stephane, Lyon, Alexander R, Omerovic, E, Citro, R, Bossone, E, Redfors, B, Backs, J, Bruns, B, Ciccarelli, M, Couch, L, Dawson, D, Grassi, G, Iacoviello, M, Parodi, G, Schneider, B, Templin, C, Ghadri, J, Thum, T, Chioncel, O, Tocchetti, C, van der Velden, J, Heymans, S, Lyon, A, University of Zurich, Cardiologie, MUMC+: MA Med Staf Spec Cardiologie (9), and RS: Carim - H02 Cardiomyopathy

Subjects
Sympathetic Nervous System, Cardiac & Cardiovascular Systems, TAKO-TSUBO CARDIOMYOPATHY, G protein coupled receptor kinase, Takotsubo syndrome, beta-adrenergic signaling, catecholamine, electrophysiology, inflammation, metabolism, pathophysiology, DIAGNOSTIC-CRITERIA, BALLOONING SYNDROME, Cardiology, 610 Medicine & health, Pathophysiology, Catecholamines, Takotsubo Cardiomyopathy, STRESS-INDUCED CARDIOMYOPATHY, Humans, Beta-adrenergic signalling, G-protein coupled receptor kinase, Heart Failure, Inflammation, VENTRICULAR DYSFUNCTION, Science & Technology, NATRIURETIC PEPTIDE, CLINICAL-FEATURES, COUPLED-RECEPTOR KINASE-5, Electrophysiology, Metabolism, QT INTERVAL PROLONGATION, 10209 Clinic for Cardiology, Cardiovascular System & Cardiology, Catecholamine, LIFE-THREATENING ARRHYTHMIAS, Life Sciences & Biomedicine
Abstract

This is the first part of a scientific statement from the Heart Failure Association (HFA) of the European Society of Cardiology focused upon the pathophysiology of Takotsubo syndrome and is complimentary to the previous HFA position statement on Takotsubo syndrome which focused upon clinical management. In part 1 we provide an overview of the pathophysiology of Takotsubo syndrome and fundamental questions to consider. We then review and discuss the central role of catecholamines and the sympathetic nervous system in the pathophysiology, and the direct effects of high surges in catecholamines upon myocardial biology including β-adrenergic receptor signalling, G-protein coupled receptor kinases, cardiomyocyte calcium physiology, myofilament physiology, cardiomyocyte gene expression, myocardial electrophysiology and arrhythmogenicity, myocardial inflammation, metabolism and energetics. The integrated effects upon ventricular haemodynamics are discussed and integrated into the pathophysiological model. ispartof: EUROPEAN JOURNAL OF HEART FAILURE vol:24 issue:2 pages:257-273 ispartof: location:England status: published

Published
2022

24. OPTImal PHARMacological therapy for patients with heart failure: Rationale and design of the OPTIPHARM-HF registry.

Author

Inciardi RM, Vaduganathan M, Lombardi CM, Gussago C, Agostoni P, Ameri P, Aspromonte N, Calò L, Cameli M, Carluccio E, Carugo S, Cipriani M, De Caterina R, De Ferrari GM, Emdin M, Fornaro A, Guazzi M, Iacoviello M, Imazio M, La Rovere MT, Leonardi S, Maccallini M, Masarone D, Moschini L, Palazzuoli A, Patti G, Pedretti RFE, Perrone Filardi P, Piepoli MF, Potena L, Salzano A, Sciacqua A, Senni M, Sinagra G, Specchia C, Taddei S, Vizza D, Savarese G, Rosano G, Volterrani M, and Metra M

Subjects
Humans, Prospective Studies, Stroke Volume physiology, Guideline Adherence, Female, Male, Italy epidemiology, Heart Failure drug therapy, Registries
Abstract

Aims: Patients with heart failure (HF) remain often undertreated for multiple reasons, including treatment inertia, contraindications, and intolerance. The OPTIimal PHARMacological therapy for patients with Heart Failure (OPTIPHARM-HF) registry is designed to evaluate the prevalence of evidence-based medical treatment prescription and titration, as well as the causes of its underuse, in a broad real-world population of consecutive patients with HF across the whole ejection fraction spectrum and among different clinical phenotypes., Methods: The OPTIPHARM-HF registry (NCT06192524) is a prospective, multicenter, observational, national study of adult patients with symptomatic HF, as defined by current international guidelines, regardless of ejection fraction. Both outpatients and inpatients with chronic and acute decompensated HF will be recruited. The study will enroll up to 2500 patients with chronic HF at approximately 35 Italian HF centres. Patients will be followed for a maximum duration of 24 months. The primary objective of the OPTIPHARM-HF registry is to assess prescription and adherence to evidence-based guideline-directed medical therapy (GDMT) in patients with HF. The primary outcome is to describe the prevalence of GDMT use according to target guideline recommendation. Secondary objectives include implementation of comorbidity treatment, evaluation of sequence of treatment introduction and up-titration, description of GDMT implementation in the specific HF population, main causes of GDMT underuse, and assessment of cumulative rate of cardiovascular events., Conclusion: The OPTIPHARM-HF registry will provide important implications for improving patient care and adoption of recommended medical therapy into clinical practice among HF patients., (© 2024 The Authors. European Journal of Heart Failure published by John Wiley & Sons Ltd on behalf of European Society of Cardiology.)

Published
2024
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25. Pathophysiology of Takotsubo syndrome - a joint scientific statement from the Heart Failure Association Takotsubo Syndrome Study Group and Myocardial Function Working Group of the European Society of Cardiology - Part 2: vascular pathophysiology, gender and sex hormones, genetics, chronic cardiovascular problems and clinical implications.

Author

Omerovic E, Citro R, Bossone E, Redfors B, Backs J, Bruns B, Ciccarelli M, Couch LS, Dawson D, Grassi G, Iacoviello M, Parodi G, Schneider B, Templin C, Ghadri JR, Thum T, Chioncel O, Tocchetti CG, van der Velden J, Heymans S, and Lyon AR

Subjects
Gonadal Steroid Hormones, Humans, Cardiology, Heart Failure genetics, MicroRNAs, Takotsubo Cardiomyopathy genetics
Abstract

While the first part of the scientific statement on the pathophysiology of Takotsubo syndrome was focused on catecholamines and the sympathetic nervous system, in the second part we focus on the vascular pathophysiology including coronary and systemic vascular responses, the role of the central and peripheral nervous systems during the acute phase and abnormalities in the subacute phase, the gender differences and integrated effects of sex hormones, genetics of Takotsubo syndrome including insights from microRNA studies and inducible pluripotent stem cell models of Takotsubo syndrome. We then discuss the chronic abnormalities of cardiovascular physiology in survivors, the limitations of current clinical and preclinical studies, the implications of the knowledge of pathophysiology for clinical management and future perspectives and directions of research., (© 2021 The Authors. European Journal of Heart Failure published by John Wiley & Sons Ltd on behalf of European Society of Cardiology.)

Published
2022
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26. Heart and brain interaction in patients with heart failure: overview and proposal for a taxonomy. A position paper from the Study Group on Heart and Brain Interaction of the Heart Failure Association.

Author

Doehner W, Ural D, Haeusler KG, Čelutkienė J, Bestetti R, Cavusoglu Y, Peña-Duque MA, Glavas D, Iacoviello M, Laufs U, Alvear RM, Mbakwem A, Piepoli MF, Rosen SD, Tsivgoulis G, Vitale C, Yilmaz MB, Anker SD, Filippatos G, Seferovic P, Coats AJS, and Ruschitzka F

Subjects
Disease Progression, Humans, Brain physiopathology, Cardiology, Cognition physiology, Consensus, Heart Failure classification, Heart Failure physiopathology, Hemodynamics physiology, Societies, Medical
Abstract

Heart failure (HF) is a complex clinical syndrome with multiple interactions between the failing myocardium and cerebral (dys-)functions. Bi-directional feedback interactions between the heart and the brain are inherent in the pathophysiology of HF: (i) the impaired cardiac function affects cerebral structure and functional capacity, and (ii) neuronal signals impact on the cardiovascular continuum. These interactions contribute to the symptomatic presentation of HF patients and affect many co-morbidities of HF. Moreover, neuro-cardiac feedback signals significantly promote aggravation and further progression of HF and are causal in the poor prognosis of HF. The diversity and complexity of heart and brain interactions make it difficult to develop a comprehensive overview. In this paper a systematic approach is proposed to develop a comprehensive atlas of related conditions, signals and disease mechanisms of the interactions between the heart and the brain in HF. The proposed taxonomy is based on pathophysiological principles. Impaired perfusion of the brain may represent one major category, with acute (cardio-embolic) or chronic (haemodynamic failure) low perfusion being sub-categories with mostly different consequences (i.e. ischaemic stroke or cognitive impairment, respectively). Further categories include impairment of higher cortical function (mood, cognition), of brain stem function (sympathetic over-activation, neuro-cardiac reflexes). Treatment-related interactions could be categorized as medical, interventional and device-related interactions. Also interactions due to specific diseases are categorized. A methodical approach to categorize the interdependency of heart and brain may help to integrate individual research areas into an overall picture., (© 2017 The Authors. European Journal of Heart Failure © 2017 European Society of Cardiology.)

Published
2018
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27. The renal arterial resistance index: a marker of renal function with an independent and incremental role in predicting heart failure progression.

Author

Ciccone MM, Iacoviello M, Gesualdo L, Puzzovivo A, Antoncecchi V, Doronzo A, Monitillo F, Citarelli G, Paradies V, and Favale S

Subjects
Aged, Cardio-Renal Syndrome diagnostic imaging, Cardio-Renal Syndrome physiopathology, Chronic Disease, Cohort Studies, Disease Progression, Echocardiography, Doppler, Color, Female, Heart Failure diagnostic imaging, Humans, Kidney diagnostic imaging, Longitudinal Studies, Male, Middle Aged, Multivariate Analysis, Prognosis, Proportional Hazards Models, Prospective Studies, Renal Artery physiopathology, Ultrasonography, Doppler, Pulsed, Heart Failure physiopathology, Kidney blood supply, Renal Artery diagnostic imaging, Vascular Resistance physiology
Abstract

Aims: The renal arterial resistance index (RRI) is a measure of renal blood flow obtained by Doppler ultrasonography, which has been demonstrated to reflect both vascular and parenchymal renal abnormalities. The aim of the study was to evaluate clinical correlates and the prognostic relevance of RRI in a group of patients affected by chronic heart failure (CHF)., Methods and Results: We enrolled 250 CHF outpatients in a stable clinical condition and receiving conventional therapy. Peak systolic velocity and end-diastolic velocity of a segmental renal artery were obtained by pulsed Doppler flow. Then the RRI was calculated. Standard renal function assessment was obtained by the measurement of creatinine serum levels and the estimation of the glomerular filtration rate (GFR). During follow-up (21.4 ± 11.3 months), 41 patients experienced heart failure progression (hospitalization and/or heart transplantation and/or death due to worsening heart failure). Considered as a continuous variable, RRI was associated with events at univariate [hazard ratio (HR) 1.14; 95% confidence interval (CI) 1.09-1.19; P < 0.001] as well as at multivariate Cox regression analysis (HR 1.08; 95% CI 1.02-1.13; P = 0.004) after correction for independent predictors of the reference model. When the RRI was added to the reference model including GFR, a significant improvement of reclassification according to both category-free net reclassification improvement (NRI, 47%; 95% CI 13-80%; P = 0.006) and integrated discrimination improvement (IDI, 0.034; 95% CI 0.006-0.061; P = 0.016) was observed., Conclusions: Quantification of arterial renal perfusion provides a new parameter that independently predicts CHF patient outcome, thus strengthening its possible role in current clinical practice in order to better characterize renal function and stratify patients' prognosis., (© 2013 The Authors. European Journal of Heart Failure © 2013 European Society of Cardiology.)

Published
2014
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