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Your search keyword '"Hunter, S J"' showing total 12 results
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12 results on '"Hunter, S J"'

2. The association between postprandial urinary C-peptide creatinine ratio and the treatment response to liraglutide: a multi-centre observational study

Author

Thong, K. Y., primary, McDonald, T. J., additional, Hattersley, A. T., additional, Blann, A. D., additional, Ramtoola, S., additional, Duncan, C., additional, Carr, S., additional, Adamson, K., additional, Nayak, A. U., additional, Khurana, R., additional, Hunter, S. J., additional, Ali, A., additional, Au, S., additional, and Ryder, R. E. J., additional

Published
2013
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12. Neuropeptide variability in man.

Author

Onuoha GN, Nugent AM, Hunter SJ, Alpar EK, McEneaney DJ, Campbell NP, Shaw C, Buchanan KD, and Nicholls DP

Subjects
Aged, Calcitonin Gene-Related Peptide blood, Chronic Disease, Endothelin-1 blood, Femoral Artery, Humans, Middle Aged, Neuropeptide Y blood, Pulmonary Artery, Radioimmunoassay, Vasoactive Intestinal Peptide blood, Veins, Heart Failure blood, Heart Failure physiopathology, Neuropeptides blood
Abstract

Background: Previous studies have established short-term variability in the circulating plasma levels of cardiac peptides such as atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP). Our aim was to investigate whether such variable patterns could be observed in other vasoactive peptides., Methods: We measured the immunoreactivity of vasoactive intestinal polypeptide (VIP), neuropeptide Y (NPY), endothelin-1 (ET-1) and calcitonin gene-related peptide (CGRP) in peripheral venous plasma collected at 2-min intervals over a 20-min period from patients with chronic cardiac failure (CCF) and from control subjects. In a second study, blood samples were obtained at 2-min intervals from the pulmonary artery, femoral artery and antecubital vein from patients with normal cardiac function while right atrial pressure and heart rate were constant., Results: Peripheral blood VIP, NPY and ET-1 had peaks and troughs (levels > 2SD from the mean) in both patients and controls, with approximate intervals of 10 min. Levels of CGRP showed little variation. The overall levels [median (range); pmol L-1] of VIP [patients 27 (2.1-85.5); controls 9.8 (0-34)] and NPY [patients 20 (0-110); controls 12 (5-19)] were higher in patients (P < 0.05). Circulating plasma levels of ET-1 and CGRP were about the same in both groups [ET-1: patients 18 (2-84); controls 18 (0-48); CGRP: patients 4 (1-18.5), controls 5.5 (1-15); P = NS]. Levels of CGRP, VIP and ET-1 were similar in the pulmonary and femoral arteries, whereas systemic arterial levels of NPY were higher than in the pulmonary artery., Conclusions: The data demonstrate marked variability in circulating levels of the neuropeptides studied. In addition, peaks and troughs were observed every 10-15 min from all three vascular beds. If these peptides are secreted in a pulsatile pattern, then interpretations of single measurements should be guarded. Furthermore, this study raises interesting questions about the physiology of hormone secretion in man.

Published
2000
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