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Your search keyword '"Hulmi, Juha J"' showing total 12 results
Start Over Author "Hulmi, Juha J" Publisher wiley
12 results on '"Hulmi, Juha J"'

1. Skeletal muscle hypertrophy rewires glucose metabolism: An experimental investigation and systematic review

Author

Baumert, Philipp, primary, Mäntyselkä, Sakari, additional, Schönfelder, Martin, additional, Heiber, Marie, additional, Jacobs, Mika Jos, additional, Swaminathan, Anandini, additional, Minderis, Petras, additional, Dirmontas, Mantas, additional, Kleigrewe, Karin, additional, Meng, Chen, additional, Gigl, Michael, additional, Ahmetov, Ildus I., additional, Venckunas, Tomas, additional, Degens, Hans, additional, Ratkevicius, Aivaras, additional, Hulmi, Juha J., additional, and Wackerhage, Henning, additional

Published
2024
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2. Skeletal muscle hypertrophy rewires glucose metabolism: an experimental investigation and systematic review

Author

Baumert, Philipp, Mäntyselkä, Sakari, Schönfelder, Martin, Heiber, Marie, Jacobs, Mika Jos, Swaminathan, Anandini, Minderis, Petras, Dirmontas, Mantas, Kleigrewe, Karin, Meng, Chen, Gigl, Michael, Ahmetov, Ildus I, Venckunas, Tomas, Degens, Hans, Ratkevicius, Aivaras, Hulmi, Juha J, Wackerhage, Henning, Baumert, Philipp, Mäntyselkä, Sakari, Schönfelder, Martin, Heiber, Marie, Jacobs, Mika Jos, Swaminathan, Anandini, Minderis, Petras, Dirmontas, Mantas, Kleigrewe, Karin, Meng, Chen, Gigl, Michael, Ahmetov, Ildus I, Venckunas, Tomas, Degens, Hans, Ratkevicius, Aivaras, Hulmi, Juha J, and Wackerhage, Henning

Abstract

BACKGROUND: Proliferating cancer cells shift their metabolism towards glycolysis, even in the presence of oxygen, to especially generate glycolytic intermediates as substrates for anabolic reactions. We hypothesize that a similar metabolic remodelling occurs during skeletal muscle hypertrophy. METHODS: We used mass spectrometry in hypertrophying C2C12 myotubes in vitro and plantaris mouse muscle in vivo and assessed metabolomic changes and the incorporation of the [U-13C6]glucose tracer. We performed enzyme inhibition of the key serine synthesis pathway enzyme phosphoglycerate dehydrogenase (Phgdh) for further mechanistic analysis and conducted a systematic review to align any changes in metabolomics during muscle growth with published findings. Finally, the UK Biobank was used to link the findings to population level. RESULTS: The metabolomics analysis in myotubes revealed insulin-like growth factor-1 (IGF-1)-induced altered metabolite concentrations in anabolic pathways such as pentose phosphate (ribose-5-phosphate/ribulose-5-phosphate: +40%; P = 0.01) and serine synthesis pathway (serine: -36.8%; P = 0.009). Like the hypertrophy stimulation with IGF-1 in myotubes in vitro, the concentration of the dipeptide l-carnosine was decreased by 26.6% (P = 0.001) during skeletal muscle growth in vivo. However, phosphorylated sugar (glucose-6-phosphate, fructose-6-phosphate or glucose-1-phosphate) decreased by 32.2% (P = 0.004) in the overloaded muscle in vivo while increasing in the IGF-1-stimulated myotubes in vitro. The systematic review revealed that 10 metabolites linked to muscle hypertrophy were directly associated with glycolysis and its interconnected anabolic pathways. We demonstrated that labelled carbon from [U-13C6]glucose is increasingly incorporated by ~13% (P = 0.001) into the non-essential amino acids in hypertrophying myotubes, which is accompanied by an increased depletion of media serine (P = 0.006). The inhibition of Phgdh suppressed muscle protein synt

Published
2024

5. Systemic blockade of ACVR2B ligands attenuates muscle wasting in ischemic heart failure without compromising cardiac function

Author

Szabó, Zoltán, primary, Vainio, Laura, additional, Lin, Ruizhu, additional, Swan, Julia, additional, Hulmi, Juha J., additional, Rahtu‐Korpela, Lea, additional, Serpi, Raisa, additional, Laitinen, Mika, additional, Pasternack, Arja, additional, Ritvos, Olli, additional, Kerkelä, Risto, additional, and Magga, Johanna, additional

Published
2020
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9. PGC-1 isoforms and their target genes are expressed differently in human skeletal muscle following resistance and endurance exercise

Author

Silvennoinen, Mika, primary, Ahtiainen, Juha P., additional, Hulmi, Juha J., additional, Pekkala, Satu, additional, Taipale, Ritva S., additional, Nindl, Bradley C., additional, Laine, Tanja, additional, Häkkinen, Keijo, additional, Selänne, Harri, additional, Kyröläinen, Heikki, additional, and Kainulainen, Heikki, additional

Published
2015
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10. Are skeletal muscleFNDC5gene expression and irisin release regulated by exercise and related to health?

Author

Pekkala, Satu, primary, Wiklund, Petri K., additional, Hulmi, Juha J., additional, Ahtiainen, Juha P., additional, Horttanainen, Mia, additional, Pöllänen, Eija, additional, Mäkelä, Kari A., additional, Kainulainen, Heikki, additional, Häkkinen, Keijo, additional, Nyman, Kai, additional, Alén, Markku, additional, Herzig, Karl-Heinz, additional, and Cheng, Sulin, additional

Published
2013
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