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Membrane permeabilities to CO2 and HCO3 - constrain the function of CO2 concentrating mechanisms that algae use to supply inorganic carbon for photosynthesis. In diatoms and green algae, plasma membranes are moderately to highly permeable to CO2 but effectively impermeable to HCO3 - . Here, CO2 and HCO3 - membrane permeabilities were measured using an 18 O-exchange technique on two species of haptophyte algae, Emiliania huxleyi and Calcidiscus leptoporus, which showed that the plasma membranes of these species are also highly permeable to CO2 (0.006-0.02 cm · s-1 ) but minimally permeable to HCO3 - . Increased temperature and CO2 generally increased CO2 membrane permeabilities in both species, possibly due to changes in lipid composition or CO2 channel proteins. Changes in CO2 membrane permeabilities showed no association with the density of calcium carbonate coccoliths surrounding the cell, which could potentially impede passage of compounds. Haptophyte plasma-membrane permeabilities to CO2 were somewhat lower than those of diatoms but generally higher than membrane permeabilities of green algae. One caveat of these measurements is that the model used to interpret 18 O-exchange data assumes that carbonic anhydrase, which catalyzes 18 O-exchange, is homogeneously distributed in the cell. The implications of this assumption were tested using a two-compartment model with an inhomogeneous distribution of carbonic anhydrase to simulate 18 O-exchange data and then inferring plasma-membrane CO2 permeabilities from the simulated data. This analysis showed that the inferred plasma-membrane CO2 permeabilities are minimal estimates but should be quite accurate under most conditions.

Despite recent advancements of sonodynamic therapy (SDT) in cancer immunotherapy, challenges have yet to be surmounted to further boost its immunotherapeutic efficacy due to the low-level tumor antigens presentation of dendritic cells (DCs). Cell membrane camouflaged-nanoparticles can integrate the neoantigens of the cancer cell membrane with the multifunctionalities of synthetic nanocores. Herein, sono-responsive nanoparticles coated with DC-targeted antibody chimeric cancer cell membrane are investigated for multimodal therapy. The nanometal organic frameworks (MOFs) that respond to ultrasound are loaded successfully inside the vesicles displaying an anti-DEC205 antibody. The anti-DEC205 chimeric vesicles can directly target and activate DCs, promote tumor antigens cross-presentation, and then produce a cascade amplified T-cell immune response. Upon deep tissue-penetrating sonication, AMR-MOF@AuPt generates large amounts of reactive oxygen species that directly kill cancer cells, further initiating an anti-cancer T cell immune response. Such synergistic sono-immunotherapies effectually inhibit tumor growth and induce strong systemic and long-term immune memory against cancer recurrence and distant metastasis. The authors findings provide DCs and tumor cells of a dual active-targeting cell membrane-coated sono-immunotherapeutic nanoplatform for cancer therapy.

Spin-orbit torques (SOTs) that arise from materials with large spin-orbit coupling offer a new pathway for energy-efficient and fast magnetic information storage. SOTs in conventional heavy metals and topological insulators are explored extensively, while 5d transition metal oxides, which also host ions with strong spin-orbit coupling, are a relatively new territory in the field of spintronics. An all-oxide, SrTiO3 (STO)//La0.7 Sr0.3 MnO3 (LSMO)/SrIrO3 (SIO) heterostructure with lattice-matched crystal structure is synthesized, exhibiting an epitaxial and atomically sharp interface between the ferromagnetic LSMO and the high spin-orbit-coupled metal SIO. Spin-torque ferromagnetic resonance (ST-FMR) is used to probe the effective magnetization and the SOT efficiency in LSMO/SIO heterostructures grown on STO substrates. Remarkably, epitaxial LSMO/SIO exhibits a large SOT efficiency, ξ|| = 1, while retaining a reasonably low shunting factor and increasing the effective magnetization of LSMO by ≈50%. The findings highlight the significance of epitaxy as a powerful tool to achieve a high SOT efficiency, explore the rich physics at the epitaxial interface, and open up a new pathway for designing next-generation energy-efficient spintronic devices.

A new core structure-motivated strategy for the intramolecular aromatic spiroketalization process was found and used for the enantioselective synthesis of bisbenzannulated spiroketals, the bioactive core of rubromycins, with high levels of enantioselectivity (up to 98% ee) via an organohalogenite-mediated asymmetric intramolecular aromatic spiroketalization. This is the first organocatalytic method for the construction of optically pure bisbenzannulated spiroketals.

Different metal ions were added as supplements to culture media to study sophorolipids production by Wickerhamiella domercqiae Y2A CGMCC 3798. The fermentation media were supplemented with different metal ions in the form of sulfate. A maximum yield 149.90 g/L was achieved in the presence of Cu2+ ions. The production of lactonic sophorolipids was favored when culture media wad supplied with Mg2+ ions, while Fe2+ ions were the optimal ions for acidic sophorolipids production. TLC, HPLC, and LC–MS analyses were used for further investigation on the sophorolipids production. The results of SDS–PAGE and enzymatic transformation of acidic sophorolipids showed differential expression of extracellular proteins of W. domercqiae Y2A CGMCC 3798 in presence of Mg2+ or Fe2+. Overall the results indicated potential selective production of different sophorolipids based on selected metal ions in culture media. Practical applications: During the fermentation process of sophorolipids, L-SLs and A-SLs were produced selectively by adding Mg2+ and Fe2+into fermentation media, respectively. Sophorolipid composition and production are different produced by Wickerhamiella domercqiae Y2A CGMCC 3798 cultured with Mg2+ (a) and Fe2+ (b), respectively by HPLC analysis.

A new core structure-motivated strategy for the intramolecular aromatic spiroketalization process was found and used for the enantioselective synthesis of bisbenzannulated spiroketals, the bioactive core of rubromycins, with high levels of enantioselectivity (up to 98% ee) via an organohalogenite-mediated asymmetric intramolecular aromatic spiroketalization. This is the first organocatalytic method for the construction of optically pure bisbenzannulated spiroketals.

The Dongmozhazhua deposit, the largest Pb–Zn deposit in south Qinghai, China, is stratabound, carbonatehosted and associated with epigenetic dolomitization and silicification of Lower–Middle Permian—Upper Triassic limestones in the hanging walls of a Cenozoic thrust fault system. The mineralization is localized in a Cenozoic thrust-folded belt along the northeastern edge of the Tibetan plateau, which was formed due to the India–Asia plate collision during the early Tertiary. The deposit comprises 16 orebodies with variable thicknesses (1.5–26.3 m) and lengths (160–1820 m). The ores occur as dissemination, vein, and breccia cement. The main sulfide assemblage is sphalerite + galena + pyrite + marcasite ± chalcopyrite ± tetrahedrite, and gangue minerals consist mainly of calcite, dolomite, barite, and quartz. Samples of pre- to post-ore stages calcite yielded d13C and d18O values that are, respectively, similar to and lower than those yielded by the host limestones, suggesting that the calcite formed from fluids derived from carbonate dissolution. Fluid inclusions in calcite and sphalerite in the polymetallic sulfidization stage mostly comprise liquid and gas phases at room temperature, with moderate homogenization temperatures (100–140°C) and high salinities (21–28 wt% NaCl eq.). Micro-thermometric fluid inclusion data point to polysaline brines as ore-forming fluids. The dD and d18O values of ore fluids, cation compositions of fluid inclusions, and geological information suggest two main possible fluid sources, namely basinal brines and evaporated seawater. The fluid inclusion data and regional geology suggest that basinal brines derived from Tertiary basins located southeast of the Dongmozhazhua deposit migrated along deep detachment zones of the regional thrust system, leached substantial base metals from country rocks, and finally ascended along thrust faults at Dongmozhazhua. There, the base-metal-rich basinal brines mixed with bacterially-reduced H2S-bearing fluids derived from evaporated seawater preserved in the Permo–Triassic carbonate strata. The mixing of the two fluids resulted in Pb–Zn mineralization. The Dongmozhazhua Pb–Zn deposit has many characteristics that are similar to MVT Pb–Zn deposits worldwide.

The crystal structure and physical properties of the double perovskite Sr 1.1 K 0.9 FeMoO 6 have been investigated. The structure of this double-perovskite compound is assigned to a tetragonal system with space group I4/mmm and X-ray diffraction data suggest that the Fe and Mo ions are partially ordered on B-sites. Thermal magnetization demonstrates that the metamagnetic transition temperature is about 275 K. At room temperature the isothermal magnetization, M―H, shows that the saturation magnetic moment per formula unit in the direction of the magnetization is 3.22μ B (300 K). The electrical resistivity is mainly governed by the Stoner spin fluctuation scattering below the metamagnetic transition and by spin waves and phonon scattering above 275 K. Evident magnetoresistance can be observed under 0.5 and 1.0 T magnetic fields in the studied temperature range.

The Tethyside orogen, a direct consequence of the separation of the Gondwanaland and the accretion of Eurasia, is a huge composite orogenic system that was generated during Paleozoic–Mesozoic Tethyan accretionary and Cenozoic continent–continent collisional orogenesis within the Tethyan domain. The Tethyside orogenic system consists of a group of diverse Tethyan blocks, including the Istanbul, Sakarya, Anatolide–Taurides, Central Iran, Afghanistan, Songpan–Ganzi, Eastern Qiangtang, Western Qiangtang, Lhasa, Indochina, Sibumasu, and Western Burma blocks, which were separated from Gondwana, drifted northwards, and accreted to the Eurasian continent by opening and closing of two successive Tethyan oceanic basins (Paleo-Tethyan and Neo-Tethyan), and subsequent continental collision. The Tethyan domain represents a metallogenic amalgamation across diverse geodynamic settings, and is the best endowed of all large orogenic systems, such as those associated with the Cordilleran and Variscan orogenies. The ore deposits within the Tethyan domain include porphyry Cu–Mo–Au, granite-related Sn–W, podiform chromite, sediment-hosted Pb–Zn deposits, volcanogenic massive sulfide (VMS) Cu–Pb–Zn deposits, epithermal and orogenic Au polymetallic deposits, as well as skarn Fe polymetallic deposits. At least two metallogenic supergroups have been identified within the eastern Tethyan metallogenic domain (ETMD): (1) metallogenesis related to the accretionary orogen, including the Zhongdian, Bangonghu, and Pontides porphyry Cu belts, the Pontides, Sanandaj–Sirjan, and Sanjiang VMS belts, the Lasbela–Khuzdar sedimentary exhalative-type (SEDEX) Pb–Zn deposits, and podiform chromite deposits along the Tethyan ophiolite zone; and (2) metallogenesis related to continental collision, including the Gangdese, Yulong, Arasbaran–Kerman and Chagai porphyry Cu belts, the Taurus, Sanandaj–Sirjan, and Sanjiang Mississippi Valley-type (MVT) Pb–Zn belts, the Southeast Asia and Tengchong–Lianghe Sn–W belts or districts, the Himalayan epithermal Sb–Au–Pb–Zn belt, the Piranshahr–Saqez–Sardasht and Ailaoshan orogenic Au belts, and the northwest Iran and northeastern Gangdese skarn Fe polymetallic belts. Mineral deposits that are generated with tectonic evolution of the Tethys form in specific settings, such as accretionary wedges, magmatic arcs, backarcs, and passive continental margins within accretionary orogens, and the foreland basins, foreland thrust zones, collisional sutures, collisional magmatic zones, and collisional deformation zones within collisional orogens. Synthesizing the architecture and tectonic evolution of collisional orogens within the ETMD and comparisons with other collisional orogenic systems have led to the identification of four basic types of collision: orthogonal and asymmetric (e.g., the Tibetan collision), orthogonal and symmetric (Pyrenees), oblique and symmetric (Alpine), and oblique and asymmetric (Zagros). The tectonic evolution of collisional orogens typically includes three major processes: (1) syn-collisional continental convergence, (2) late-collisional tectonic transform, and (3) post-collisional crustal extension, each forming distinct types of ore deposits in specific settings. The resulting synthesis leads us to propose a new conceptual framework for the collision-related metallogenic systems, which may aid in deciphering relationships among ore types in other comparable collisional orogens. Three significant processes, such as breaking-off of subducted Tethyan slab, large-scale strike-slip faulting, shearing and thrusting, and delamination (or broken-off) of lithosphere, developed in syn-, late- and post-collisional periods, repsectively, were proposed to act as major driving forces, resulting in the formation of the collision-related metallogenic systems. Widespread appearance of juvenile crust and intense inteaction between mantle and crust within the Himalayan–Zagros orogens indicate that collisional orogens have great potential for the discovery of large or giant mineral deposits.