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Your search keyword '"Higgins, Claire"' showing total 29 results
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29 results on '"Higgins, Claire"'

4. Refugees are a valuable but overlooked economic resource, and it is time to update our approach to migration

Author

Tani Bertuol, Massimiliano ; https://orcid.org/0000-0001-7642-8343, Baker, sally ; https://orcid.org/0000-0001-9143-5816, Higgins, claire ; https://orcid.org/0000-0003-1756-4200, Cousins, Stephanie, Tani Bertuol, Massimiliano ; https://orcid.org/0000-0001-7642-8343, Baker, sally ; https://orcid.org/0000-0001-9143-5816, Higgins, claire ; https://orcid.org/0000-0003-1756-4200, and Cousins, Stephanie

Abstract

The view that welcoming refugees represents a cost to a country's welfare services has become anachronistic; nowadays refugees are increasingly recognised for their high levels of education and skills, and their ability to make an economic contribution to a host country. Yet, most states' approach to migration management prevents displaced people from migrating based on the human capital that they can supply. Australia is trialling a new approach that enables refugees to access skilled migration through employer sponsorship. This article describes the pilot project and suggests ways to encourage employers to view refugees as a valuable solution to workforce shortages.

Published
2022

9. Methods for the isolation and 3D culture of dermal papilla cells from human hair follicles

Author

Topouzi, Helena, Logan, Niall J., Williams, Greg, Higgins, Claire A., and Medical Research Council (MRC)

Subjects
ANDROGENETIC ALOPECIA, Biopsy, Cell Culture Techniques, Methods Review (Invited), Cell Count, Cell Separation, Dermatology, spheroid culture, dermal papilla, inversion, stomatognathic system, REGENERATION, Skin Physiological Phenomena, Cell Adhesion, Humans, Cells, Cultured, Skin, Science & Technology, integumentary system, hair follicle, urogenital system, INDUCTION, Dermatology & Venereal Diseases, Mesenchymal Stem Cells, micro-dissection, 1103 Clinical Sciences, Dermis, Extracellular Matrix, STEM-CELL, PATTERN, DIFFERENTIATION, GROWTH, RAT, micro‐dissection, Life Sciences & Biomedicine, SHEATH, Hair
Abstract

The dermal papilla is a cluster of mesenchymal cells located at the base of the hair follicle which have a number of important roles in the regulation of hair growth. As a consequence, in vitro models of these cells are widely used to study the molecular mechanisms which underlie hair follicle induction, growth and maintenance. While dermal papilla from rodent hair follicles can be digested prior to cell isolation, the unique extracellular matrix composition found in human dermal papilla renders enzymes such as trypsin and collagenase insufficient for digestion of the dermal papilla into a single cell suspension. As such, to grow human dermal papilla cells in vitro, the papilla has to first be isolated via a micro‐dissection approach from the follicle. In this article we describe the micro‐dissection and culture methods, which we use within our laboratory, for the study of human dermal papilla cells.

Published
2017

27. Atypical cutaneous manifestations of methicillin resistant Staphylococcus aureus infections in two immunocompetent pediatric patients: Case reports and review of the literature.

Author

Bash GN, Higgins C, McClanahan D, Dunlap R, Dhossche J, Leitenberger S, Small A, Koon SM, White KP, and Funk T

Subjects
Humans, Male, Female, Child, Immunocompetence, Diagnosis, Differential, Anti-Bacterial Agents therapeutic use, Panniculitis diagnosis, Panniculitis microbiology, Panniculitis drug therapy, Panniculitis pathology, Staphylococcal Infections drug therapy, Staphylococcal Infections diagnosis, Child, Preschool, Methicillin-Resistant Staphylococcus aureus isolation & purification, Staphylococcal Skin Infections drug therapy, Staphylococcal Skin Infections diagnosis
Abstract

Although many clinical variants of Staphylococcus aureus infection are well-recognized, atypical presentations may mimic other conditions. We describe two cases of atypical S. aureus infections in pediatric patients: a S. aureus infection presenting with a vesicopustular rash mimicking varicella zoster virus and a case of multifocal panniculitis. Both of these cases were specifically caused by methicillin-resistant S. aureus (MRSA). Additional cases of atypical S. aureus infections and presenting features from the current literature are also discussed., (© 2024 Wiley Periodicals LLC.)

Published
2025
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29. Mast cells reside in myometrium and cervix, but are dispensable in mice for successful pregnancy and labor.

Author

Menzies FM, Higgins CA, Shepherd MC, Nibbs RJ, and Nelson SM

Subjects
Animals, Cervix Uteri immunology, Female, Gene Expression Regulation genetics, Gene Expression Regulation immunology, Humans, Interleukin-10 genetics, Interleukin-10 metabolism, Mast Cells immunology, Mast Cells pathology, Mice, Mice, Inbred C57BL, Mice, Knockout, Myometrium immunology, Parturition genetics, Pregnancy, Receptors, IgE genetics, Receptors, IgE metabolism, Uterine Contraction genetics, Cervix Uteri metabolism, Mast Cells metabolism, Myometrium metabolism, Parturition immunology
Abstract

Parturition is associated with myometrial and cervical inflammation. The causes and consequences of this inflammatory response are not clear. Mast cells (MCs) are important inducers of allergic and non-allergic inflammation, and their secreted products can induce myometrial contractions. Thus, mast cell activation has been hypothesized to have a role in initiating labor and/or driving labor-associated inflammation. We report that small numbers of MCs expressing chymase and tryptase are present in the myometrium and cervix of pregnant women. Labor did not lead to any change in mast cell abundance in these tissues, but was associated with reduced expression of the mast-cell regulator FcεR1A, indicative of a change in mast cell properties. This coincided with contraction-dependent myocyte production of interleukin-10 (IL-10), a known suppressor of FcεR1A expression. MCs were also found in the uterine horn and cervical region of pregnant C57BL/6 mice, increasing in number in the cervix, but not the myometrium, with labor. As expected, these cells were absent from mast-cell-deficient Kit(W-sh) mice. Nonetheless, pregnant Kit(W-sh) mice showed no defects in the timing of labor induction or in the upregulation of leukocyte markers during labor. Thus, MCs are present in the uterus and cervix of humans and mice, and our mouse studies suggest that they do not have a vital role in the induction of labor, or in the promotion of labor-associated inflammation.

Published
2012
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