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Purpose: To implement a free-breathing sequence for simultaneous quantification of T 1 , T 2 , and T 2 ∗ for comprehensive tissue characterization of the myocardium in a single scan using a multi-gradient-echo readout with saturation and T 2 preparation pulses., Methods: In the proposed Saturation And T 2 -prepared Relaxometry with Navigator-gating (SATURN) technique, a series of multi-gradient-echo (GRE) images with different magnetization preparations was acquired during free breathing. A total of 35 images were acquired in 26.5 ± 14.9 seconds using multiple saturation times and T 2 preparation durations and with imaging at 5 echo times. Bloch simulations and phantom experiments were used to validate a 5-parameter fit model for accurate relaxometry. Free-breathing simultaneous T 1 , T 2 , and T 2 ∗ measurements were performed in 10 healthy volunteers and 2 patients using SATURN at 3T and quantitatively compared to conventional single-parameter methods such as SASHA for T 1 , T 2 -prepared bSSFP, and multi-GRE for T 2 ∗ ., Results: Simulations confirmed accurate fitting with the 5-parameter model. Phantom measurements showed good agreement with the reference methods in the relevant range for in vivo measurements. Compared to single-parameter methods comparable accuracy was achieved. SATURN produced in vivo parameter maps that were visually comparable to single-parameter methods. No significant difference between T 1 , T 2 , and T 2 ∗ times acquired with SATURN and single-parameter methods was shown in quantitative measurements (SATURN T 1 = 1573 ± 86 ms , T 2 = 33.2 ± 3.6 ms , T 2 ∗ = 25.3 ± 6.1 ms ; conventional methods: T 1 = 1544 ± 107 ms , T 2 = 33.2 ± 3.6 ms , T 2 ∗ = 23.8 ± 5.5 ms ; P > . 2 ) CONCLUSION: SATURN enables simultaneous quantification of T 1 , T 2 , and T 2 ∗ in the myocardium for comprehensive tissue characterization with co-registered maps, in a single scan with good agreement to single-parameter methods., (© 2021 The Authors. Magnetic Resonance in Medicine published by Wiley Periodicals LLC on behalf of International Society for Magnetic Resonance in Medicine.)

Purpose: To develop an accelerated postprocessing pipeline for reproducible and efficient assessment of white matter lesions using quantitative magnetic resonance fingerprinting (MRF) and deep learning., Methods: MRF using echo-planar imaging (EPI) scans with varying repetition and echo times were acquired for whole brain quantification of T 1 and T 2 ∗ in 50 subjects with multiple sclerosis (MS) and 10 healthy volunteers along 2 centers. MRF T 1 and T 2 ∗ parametric maps were distortion corrected and denoised. A CNN was trained to reconstruct the T 1 and T 2 ∗ parametric maps, and the WM and GM probability maps., Results: Deep learning-based postprocessing reduced reconstruction and image processing times from hours to a few seconds while maintaining high accuracy, reliability, and precision. Mean absolute error performed the best for T 1 (deviations 5.6%) and the logarithmic hyperbolic cosinus loss the best for T 2 ∗ (deviations 6.0%)., Conclusions: MRF is a fast and robust tool for quantitative T 1 and T 2 ∗ mapping. Its long reconstruction and several postprocessing steps can be facilitated and accelerated using deep learning., (© 2021 The Authors. Magnetic Resonance in Medicine published by Wiley Periodicals LLC on behalf of International Society for Magnetic Resonance in Medicine.)

Purpose: To evaluate the use of magnetic resonance fingerprinting (MRF) for simultaneous quantification of T 1 and T 2 ∗ in a single breath-hold in the kidneys., Methods: The proposed kidney MRF sequence was based on MRF echo-planar imaging. Thirty-five measurements per slice and overall 4 slices were measured in 15.4 seconds. Group matching was performed for in-line quantification of T 1 and T 2 ∗ . Images were acquired in a phantom and 8 healthy volunteers in coronal orientation. To evaluate our approach, region of interests were drawn in the kidneys to calculate mean values and standard deviations of the T 1 and T 2 ∗ times. Precision was calculated across multiple repeated MRF scans. Gaussian filtering is applied on baseline images to improve SNR and match stability., Results: T 1 and T 2 ∗ times acquired with MRF in the phantom showed good agreement with reference measurements and conventional mapping methods with deviations of less than 5% for T 1 and less than 10% for T 2 ∗ . Baseline images in vivo were free of artifacts and relaxation times yielded good agreement with conventional methods and literature (deviation T 1 : 7 ± 4 % , T 2 ∗ : 6 ± 3 % )., Conclusions: In this feasibility study, the proposed renal MRF sequence resulted in accurate T 1 and T 2 ∗ quantification in a single breath-hold., (© 2020 The Authors. Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine.)