26 results on '"Hasan O"'
Search Results
2. Extramedullary Plasmacytoma of the Maxillary Sinuses in a Patient With Multiple Myeloma
- Author
-
Caleb Boehler, Hasan Ozgur, Christopher Le, and Samuel Rogers
- Subjects
extramedullary plasmacytoma ,maxillary sinus ,multiple myeloma ,Otorhinolaryngology ,RF1-547 ,Surgery ,RD1-811 - Published
- 2024
- Full Text
- View/download PDF
3. Mating Season Influences Placental Characteristics, Plasma IGF Concentration, and mRNA Expression without Affecting Lamb Birth Weight in Akkaraman Ewes
- Author
-
Uğur Şen, Emre Şirin, Hasan Önder, Cem Tırınk, Aycan Mutlu Yağanoğlu, Saule Bostanova, Rashit Uskenov, and Thobela Louis Tyasi
- Subjects
Veterinary medicine ,SF600-1100 - Abstract
Seasonal variations significantly impact lambs’ birth weight and post-natal growth of lambs, yet the underlying physiological mechanisms remain insufficiently explored. Therefore, this study examined the effects of mating season on lamb birth weight, placental characteristics, maternal concentrations of insulin-like growth factors (IGFs) in plasma, and placental mRNA expression levels of IGFs in Akkaraman ewes reared under extensive conditions. Ewes were mated in the breeding season (September; n = 35) and out-of-breeding season (April; n = 27). Blood samples were taken from the jugular vein of all ewes using a vacutainer in sterile heparin tubes every month from mating to parturition. Post-lambing, both dam and lamb weights were recorded, and placental characteristics were documented within 12 hours of parturition in both seasons. The number and weight of cotyledons were higher (P
- Published
- 2024
- Full Text
- View/download PDF
4. Adult polyglucosan body disease presenting as a unilateral progressive plexopathy
- Author
-
Anthony J. Windebank, Elie Naddaf, Charles D. Kassardjian, Hasan O. Akman, and Yasemin Gulcan Kurt
- Subjects
0301 basic medicine ,Pathology ,medicine.medical_specialty ,Nerve biopsy ,Pyramidal tracts ,medicine.diagnostic_test ,Physiology ,business.industry ,Adult polyglucosan body disease ,medicine.disease ,Plexopathy ,03 medical and health sciences ,Cellular and Molecular Neuroscience ,030104 developmental biology ,0302 clinical medicine ,medicine.anatomical_structure ,Atrophy ,Physiology (medical) ,Corticospinal tract ,medicine ,Neurology (clinical) ,Endoneurium ,business ,030217 neurology & neurosurgery ,Lumbosacral joint - Abstract
Introduction Adult polyglucosan body disease (APBD) usually presents with progressive spastic paraparesis, neurogenic bladder, and distal lower limb sensory abnormalities. It is caused by mutations in the glycogen branching enzyme gene (GBE1). Methods We describe a woman with an unusual phenotype manifesting as progressive left brachial more than lumbosacral plexopathies, with central sensory and corticospinal tract involvement. Results Magnetic resonance imaging of the brain and cervical spine showed abnormal T2 signal within the ventral pons and medulla bilaterally, involving the pyramidal tracts and the medial leminisci. There was also medullary and cervical spine atrophy. On nerve biopsy, large polyglucosan bodies were noted in the endoneurium. The patient was found to be compound heterozygous for 2 novel mutations in GBE1. Peripheral blood leukocyte GBE activity was markedly reduced to 7% of normal, confirming the diagnosis of APBD. Conclusions In this report we describe a new phenotype of APBD associated with 2 novel mutations. Muscle Nerve 53: 976-981, 2016.
- Published
- 2016
5. A myopathy with unusual features caused byPNPLA2gene mutations
- Author
-
Daniela Tavian, Hasan O. Akman, Salvatore DiMauro, Sara Missaglia, Elena Maria Pennisi, and Cinzia Bernardi
- Subjects
medicine.medical_specialty ,Physiology ,Mutant ,Lipid metabolism ,Exercise intolerance ,Biology ,Gene mutation ,Cellular and Molecular Neuroscience ,Exon ,Endocrinology ,Biochemistry ,Physiology (medical) ,Lipid droplet ,Internal medicine ,Adipose triglyceride lipase ,medicine ,Neurology (clinical) ,medicine.symptom ,Myopathy - Abstract
Introduction: The PNPLA2 gene encodes the enzyme adipose triglyceride lipase (ATGL), which catalyzes the first step of triglyceride hydrolysis. Mutations in this gene are associated with an autosomal recessive lipid-storage myopathy, neutral lipid-storage disease with myopathy (NLSD-M). Results: A 72-year-old woman had late-onset myopathy, with mild weakness, cramps, and exercise intolerance. Electromyography showed myotonic discharges. A few leukocytes showed lipid droplets (Jordan anomaly). Deltoid and quadriceps muscle biopsies showed no lipid storage. Genetic analysis of PNPLA2 detected 2 heterozygous mutations: c.497A>G (p.Asp166Gly) in exon 5 and c.1442C>T (p.Pro481Leu) in exon 10. Expression of mutant PNPLA2 plasmids in HeLa cells resulted in impaired enzyme activity, confirming the pathological effects of the mutations. Conclusions: In this case of NLSD-M, the myopathy may be due to a metabolic defect rather than to a mechanical effect of lipid storage. This suggests that more than 1 mechanism contributes to muscle damage in NLSD-M. Muscle Nerve 51: 609–613, 2015
- Published
- 2015
6. Cerebral blood flow pulsatility and cerebral artery stiffness acutely decrease during hemodialysis
- Author
-
Mathilde Paré, Hasan Obeid, Lawrence Labrecque, Audrey Drapeau, Patrice Brassard, and Mohsen Agharazii
- Subjects
arterial stiffness ,cerebral pulsatility index ,end‐stage kidney disease ,hemodialysis ,middle cerebral artery mean blood velocity ,pulse wave velocity ,Physiology ,QP1-981 - Abstract
Abstract End‐stage kidney disease (ESKD) is associated with increased arterial stiffness and cognitive impairment. Cognitive decline is accelerated in ESKD patients on hemodialysis and may result from repeatedly inappropriate cerebral blood flow (CBF). The aim of this study was to examine the acute effect of hemodialysis on pulsatile components of CBF and their relation to acute changes in arterial stiffness. In eight participants (age: 63 ± 18 years, men: 5), CBF was estimated using middle cerebral artery blood velocity (MCAv) assessed with transcranial Doppler ultrasound before, during, and after a single hemodialysis session. Brachial and central blood pressure, along with estimated aortic stiffness (eAoPWV) were measured using an oscillometric device. Arterial stiffness from heart to MCA was measured as the pulse arrival time (PAT) between electrocardiogram (ECG) and transcranial Doppler ultrasound waveforms (cerebral PAT). During hemodialysis, there was a significant reduction in mean MCAv (−3.2 cm/s, p
- Published
- 2023
- Full Text
- View/download PDF
7. Adult polyglucosan body disease: A case report of a manifesting heterozygote
- Author
-
Eroboghene E. Ubogu, Hasan O. Akman, Stacey Tay Kiat Hong, Salvatore DiMauro, David C. Preston, Barbara E. Shapiro, and Bashar Katirji
- Subjects
Male ,Heterozygote ,Pathology ,medicine.medical_specialty ,Physiology ,Molecular Sequence Data ,Sural nerve ,Diagnosis, Differential ,Glycogen Storage Disease Type IV ,Cellular and Molecular Neuroscience ,chemistry.chemical_compound ,Degenerative disease ,1,4-alpha-Glucan Branching Enzyme ,Physiology (medical) ,medicine ,Humans ,Point Mutation ,Glycogen storage disease ,Glucans ,Aged ,Inclusion Bodies ,Base Sequence ,Glycogen ,business.industry ,Leukodystrophy ,Brain ,Adult polyglucosan body disease ,medicine.disease ,Magnetic Resonance Imaging ,Peripheral neuropathy ,chemistry ,Jews ,Chromosomes, Human, Pair 3 ,Neurology (clinical) ,business ,Rare disease - Abstract
A 62-year-old man developed progressive gait instability, bladder dysfunction, proximal weakness, distal sensory loss, and mild cognitive impairment over 6 years. Neurologic examination revealed upper and lower motor neuron dysfunction in the lower extremities, with distal sensory loss. Electrodiagnostic studies, magnetic resonance imaging of the brain, and sural nerve biopsy were consistent with adult polyglucosan body disease. Biochemical and genetic analyses demonstrated reduced glycogen brancher enzyme levels associated with a heterozygous point mutation (Tyr329Ser or Y329S) in the glycogen brancher enzyme gene on chromosome 3. Mutational heterozygosity in the glycogen brancher enzyme gene has not been previously reported as a cause for this rare disease. A review of the clinical presentation, pathogenesis, etiology, and diagnosis of this disease is presented.
- Published
- 2005
8. Genetic diagnosis of Bartter syndrome in Iranian patients and detection of a novel homozygous CLCNKB mutation
- Author
-
Somayeh Takrim Nojehdeh, Marzieh Mojbafan, Nakysa Hooman, Rozita Hoseini, and Hasan Otukesh
- Subjects
Bartter syndrome ,CLC‐kb ,In silico analysis ,sanger sequencing ,Medicine ,Medicine (General) ,R5-920 - Abstract
Abstract An Iranian girl with clinical symptoms of Bartter syndrome like hypokalemia, polyuria, polydipsia, hyponatremia, and hypochloremic alkalosis was referred to us in whom the CLCNKB gene was genetically evaluated using Sanger sequencing. A homozygous pathogenic variant of c.1332_1335delCTCT was detected in this patient.
- Published
- 2022
- Full Text
- View/download PDF
9. Outcomes after cesarean myomectomy versus cesarean alone among pregnant women with uterine leiomyomas
- Author
-
Topçu, Hasan O., primary, İskender, Can T., additional, Timur, Hakan, additional, Kaymak, Oktay, additional, Memur, Tuba, additional, and Danışman, Nuri, additional
- Published
- 2015
- Full Text
- View/download PDF
10. Levodopa Responsive Parkinsonism in Two Patients With Phosphoglycerate Kinase Deficiency
- Author
-
Virmani, Tuhin, primary, Rotstein, Michael, additional, Spiegel, Ronen, additional, Akman, Hasan O., additional, DiMauro, Salvatore, additional, and Greene, Paul E., additional
- Published
- 2014
- Full Text
- View/download PDF
11. Polyglucosan body myopathy caused by defective ubiquitin ligase RBCK1
- Author
-
Nilsson, Johanna, primary, Schoser, Benedikt, additional, Laforet, Pascal, additional, Kalev, Ognian, additional, Lindberg, Christopher, additional, Romero, Norma B., additional, Dávila López, Marcela, additional, Akman, Hasan O., additional, Wahbi, Karim, additional, Iglseder, Stephan, additional, Eggers, Christian, additional, Engel, Andrew G., additional, DiMauro, Salvatore, additional, and Oldfors, Anders, additional
- Published
- 2013
- Full Text
- View/download PDF
12. The Role of Inflammation after Surgery for Elders (RISE) study: Study design, procedures, and cohort profile
- Author
-
Tammy T. Hshieh, Sarinnapha M. Vasunilashorn, Madeline L. D'Aquila, Steven E. Arnold, Bradford C. Dickerson, Tamara G. Fong, Richard N. Jones, Edward R. Marcantonio, Eva M. Schmitt, Guoquan Xu, Yun Gou, Fan Chen, Lisa J. Kunze, Kamen V. Vlassakov, Ayesha R. Abdeen, Jeffrey K. Lange, Brandon E. Earp, Alexandra Touroutoglou, Becky C. Carlyle, Pia Kivisakk‐Webb, Thomas G. Travison, Simon T. Dillon, Towia A. Libermann, Sharon K. Inouye, RISE Study Group, Steven Arnold, Bradford Dickerson, Tamara Fong, Richard Jones, Thomas Travison, Michele Cavallari, Jacob Hooker, Tammy Hshieh, Savannah Kandigian, Long Ngo, Hasan Otu, Bianca Trombetta, Sarinnapha Vasunilashorn, Ayesha Abdeen, Douglas Ayres, Brandon Earp, Jeffrey Lange, Gregory Brick, Antonia Chen, Robert Davis, Jacob Drew, Richard Iorio, Fulton Kornack, Michael Weaver, Anthony Webber, Richard Wilk, Lisa Kunze, David Shaff, Kamen Vlassakov, Brett Armstrong, Angelee Banda, Sylvie Bertrand, Madeline D'Aquila, Jacqueline Gallagher, Baileigh Hightower, Shannon Malloy, Jacqueline Nee, Chloe Nobuhara, Abigail Overstreet, Annie Racine, David Urick, Grae Arabasz, Michael Brickhouse, Regan Butterfield, Shirley Hsu, Sara Makaretz, Judit Sore, Douglas Tommet, Sabrina Carretie, Ted Gruen, and Katherine Tasker
- Subjects
Inflammation ,Biomarkers ,Plasma ,Cerebrospinal fluid ,Positron emission tomography ,Surgery ,Neurology. Diseases of the nervous system ,RC346-429 ,Geriatrics ,RC952-954.6 - Abstract
Abstract Introduction The Role of Inflammation after Surgery for Elders study correlates novel inflammatory markers measured in blood, cerebrospinal fluid (CSF) assays, and [11C]‐PBR28 positron‐emission tomography imaging. Methods This study involved a prospective cohort design with patients who underwent elective hip and knee arthroplasty under spinal anesthesia. Sixty‐five adults participated with their family members. Inflammatory biomarker assays were measured preoperatively on day 1 and postoperatively at one month. Results On average, participants were 75 years old, and 72% were female. 54% underwent total knee arthroplasty, and 46% underwent total hip arthroplasty. The mean Modified Mini‐Mental State (3MS) Examination score was 89.3; four patients (6%) scored ≤77 points. Plasma assays were completed in 63 (97%) participants, cerebrospinal fluid assays in 61 (94%), and PET imaging in 44 (68%). Discussion This complex study presents an innovative effort to correlate peripheral and central inflammatory biomarkers before and after major surgery in older adults. Strengths include collecting concurrent blood, cerebrospinal fluid, and positron‐emission tomography with detailed clinical characterization of delirium, cognition, and functional status.
- Published
- 2019
- Full Text
- View/download PDF
13. Adult polyglucosan body disease: Natural History and Key Magnetic Resonance Imaging Findings
- Author
-
Mochel, Fanny, primary, Schiffmann, Raphael, additional, Steenweg, Marjan E., additional, Akman, Hasan O., additional, Wallace, Mary, additional, Sedel, Frédéric, additional, Laforêt, Pascal, additional, Levy, Richard, additional, Powers, J. Michael, additional, Demeret, Sophie, additional, Maisonobe, Thierry, additional, Froissart, Roseline, additional, Da Nobrega, Bruno Barcelos, additional, Fogel, Brent L., additional, Natowicz, Marvin R., additional, Lubetzki, Catherine, additional, Durr, Alexandra, additional, Brice, Alexis, additional, Rosenmann, Hanna, additional, Barash, Varda, additional, Kakhlon, Or, additional, Gomori, J. Moshe, additional, van der Knaap, Marjo S., additional, and Lossos, Alexander, additional
- Published
- 2012
- Full Text
- View/download PDF
14. A constitutive model for the nonlinear viscoelastic viscoplastic behavior of glassy polymers
- Author
-
Hasan, O. A., primary and Boyce, M. C., additional
- Published
- 1995
- Full Text
- View/download PDF
15. Identification and quantification of endogenous gibberellins in apical buds and the cambial region of Eucalyptus
- Author
-
Hasan, O., primary, Ridoutt, B. G., additional, Ross, J. J., additional, Davies, N. W., additional, and Reid, J. B., additional
- Published
- 1994
- Full Text
- View/download PDF
16. An Artificial Neural Network Model to Predict the Thermal Properties of Concrete Using Different Neurons and Activation Functions
- Author
-
Sehmus Fidan, Hasan Oktay, Suleyman Polat, and Sarper Ozturk
- Subjects
Materials of engineering and construction. Mechanics of materials ,TA401-492 - Abstract
Growing concerns on energy consumption of buildings by heating and cooling applications have led to a demand for improved insulating performances of building materials. The establishment of thermal property for a building structure is the key performance indicator for energy efficiency, whereas high accuracy and precision tests are required for its determination which increases time and experimental costs. The main scope of this study is to develop a model based on artificial neural network (ANN) in order to predict the thermal properties of concrete through its mechanical characteristics. Initially, different concrete samples were prepared, and their both mechanical and thermal properties were tested in accordance with ASTM and EN standards. Then, the Levenberg–Marquardt algorithm was used for training the neural network in the single hidden layer using 5, 10, 15, 20, and 25 neurons, respectively. For each thermal property, various activation functions such as tangent sigmoid functions and triangular basis functions were used to examine the best solution performance. Moreover, a cross-validation technique was used to ensure good generalization and to avoid overtraining. ANN results showed that the best overall R2 performances for the prediction of thermal conductivity, specific heat, and thermal diffusivity were obtained as 0.996, 0.983, and 0.995 for tansig activation functions with 25, 25, and 20 neurons, respectively. The performance results showed that there was a great consistency between the predicted and tested results, demonstrating the feasibility and practicability of the proposed ANN models for predicting the thermal property of a concrete.
- Published
- 2019
- Full Text
- View/download PDF
17. The Effect of Taxifolin on Cisplatin-Induced Pulmonary Damage in Rats: A Biochemical and Histopathological Evaluation
- Author
-
Edhem Unver, Mustafa Tosun, Hasan Olmez, Mehmet Kuzucu, Ferda Keskin Cimen, and Zeynep Suleyman
- Subjects
Pathology ,RB1-214 - Abstract
The effect of taxifolin on cisplatin-induced oxidative pulmonary damage was investigated biochemically and histopathologically in male albino Wistar rats. There were four groups, with six animals in each group: 50 mg/kg of taxifolin plus 2.5 mg/kg of cisplatin (TC) group, 2.5 mg/kg of cisplatin only (CIS) group, 50 mg/kg of taxifolin only (TG) group, and a healthy control group (HG). In terms of the experimental procedure, the animals in the TC and TG groups were first treated via oral gavage. The CIS and HG groups received distilled water as solvent, respectively. One hour later, the TC and CIS groups received cisplatin at a dose of 2.5 mg/kg (injected intraperitoneally). Taxifolin, cisplatin, and the distilled water were administered at the indicated dose and volume, using the same method daily for 14 d. At the end of this period, the animals were killed with a high dosage of thiopental anaesthesia (50 mg/kg). Blood and lung tissue samples were taken for biochemical (malondialdehyde (MDA), myeloperoxidase (MPO), total glutathione (tGSH), and 8-hydroxy-2 deoxyguanosine (8-OHdG)) analyses and histopathological examinations. The biochemical and histopathological results in the TC and HG groups were then compared with those in the CIS group. Cisplatin increased the levels of MDA, myeloperoxidase, and 8-OHdG, a marker of oxidative DNA damage, and reduced the amount of tGSH in the lung tissue. Moreover, severe alveolar damage, including oedema and extensive alveolar septal fibrosis, in addition to infiltration of polymorphic nuclear leucocytes and haemorrhagic foci, was observed in the CIS group. These histopathological findings demonstrate that taxifolin provides protection against pulmonary oxidative stress by preventing increases in oxidant parameters and decreases in antioxidants.
- Published
- 2019
- Full Text
- View/download PDF
18. Cross Section Prediction for Inclusive Production of Z Boson in pp Collisions at s=14 TeV: A Study of Systematic Uncertainty due to Scale Dependence
- Author
-
Hasan Ogul and Kamuran Dilsiz
- Subjects
Physics ,QC1-999 - Abstract
Prediction of Z→l+l- production cross section (where l±=e±,μ±) in proton-proton collisions at s=14 TeV is estimated up to next-to-next-to-leading order (NNLO) in perturbative QCD including next-to-leading order (NLO) electroweak (EW) corrections. The total inclusive Z boson production cross section times leptonic branching ratio, within the invariant mass window 66
- Published
- 2017
- Full Text
- View/download PDF
19. High Order QCD Predictions for Inclusive Production of W Bosons in pp Collisions at s=13 TeV
- Author
-
Hasan Ogul, Kamuran Dilsiz, Emrah Tiras, Ping Tan, Yasar Onel, and Jane Nachtman
- Subjects
Physics ,QC1-999 - Abstract
Predictions of fiducial cross sections, differential cross sections, and lepton charge asymmetry are presented for the production of W± bosons with leptonic decay up to next-to-next-to-leading order (NNLO) in perturbative QCD. Differential cross sections of W± bosons and W boson lepton charge asymmetry are computed as a function of lepton pseudorapidity for a defined fiducial region in pp collisions at s=13 TeV. Numerical results of fiducial W± cross section predictions are presented with the latest modern PDF models at next-to-leading order (NLO) and NNLO. It is found that the CT14 and NNPDF 3.0 predictions with NNLO QCD corrections are about 4% higher than the NLO CT14 and NNPDF 3.0 predictions while MMHT 2014 predictions with NLO QCD corrections are smaller than its NNLO QCD predictions by approximately 6%. In addition, the NNLO QCD corrections reduce the scale variation uncertainty on the cross section by a factor of 3.5. The prediction of central values and considered uncertainties are obtained using FEWZ 3.1 program.
- Published
- 2016
- Full Text
- View/download PDF
20. The Utility of Serum Receptor-Binding Cancer Antigen Expressed on Siso Cells in Gastrointestinal Tract Cancers
- Author
-
Şahin Çoban, Hasan Özkan, Seyfettin Köklü, Osman Yüksel, Muhammed Cem Koçkar, Tarik Akar, and Necati Örmeci
- Subjects
Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
BACKGROUND: Receptor-binding cancer antigen expressed on SiSo cells (RCAS1) is a novel tumour marker that has been described in various kinds of cancer. The majority of observations include immunohistochemical studies; however, there are not enough data about the utility of this antigen as a serum tumour marker and its tumour specificity.
- Published
- 2006
- Full Text
- View/download PDF
21. On the Homomorphisms of the Lie Groups and
- Author
-
Fatma Özdemir and Hasan Özekes
- Subjects
Mathematics ,QA1-939 - Abstract
We first construct all the homomorphisms from the Heisenberg group to the 3-sphere. Also, defining a topology on these homomorphisms, we regard the set of these homomorphisms as a topological space. Next, using the kernels of homomorphisms, we define an equivalence relation on this topological space. We finally show that the quotient space is a topological group which is isomorphic to .
- Published
- 2013
- Full Text
- View/download PDF
22. On New Inequalities via Riemann-Liouville Fractional Integration
- Author
-
Mehmet Zeki Sarikaya and Hasan Ogunmez
- Subjects
Mathematics ,QA1-939 - Abstract
We extend the Montgomery identities for the Riemann-Liouville fractional integrals. We also use these Montgomery identities to establish some new integral inequalities. Finally, we develop some integral inequalities for the fractional integral using differentiable convex functions.
- Published
- 2012
- Full Text
- View/download PDF
23. Formal reasoning about synthetic biology using higher-order-logic theorem proving.
- Author
-
Abed S, Rashid A, and Hasan O
- Subjects
- Models, Biological, Logic, Computer Simulation, Algorithms, Models, Genetic, Humans, Synthetic Biology, Gene Regulatory Networks
- Abstract
Synthetic biology is an interdisciplinary field that uses well-established engineering principles for performing the analysis of the biological systems, such as biological circuits, pathways, controllers and enzymes. Conventionally, the analysis of these biological systems is performed using paper-and-pencil proofs and computer simulation methods. However, these methods cannot ensure accurate results due to their inherent limitations. Higher-order-logic (HOL) theorem proving is proposed and used as a complementary approach for analysing linear biological systems, which is based on developing a mathematical model of the genetic circuits and the bio-controllers used in synthetic biology based on HOL and analysing it using deductive reasoning in an interactive theorem prover. The involvement of the logic, mathematics and the deductive reasoning in this method ensures the accuracy of the analysis. It is proposed to model the continuous dynamics of the genetic circuits and their associated controllers using differential equations and perform their transfer function-based analysis using the Laplace transform in a theorem prover. For illustration, the genetic circuits of activated and repressed expressions and autoactivation of protein, and phase lag and lead controllers, which are widely used in cancer-cell identifiers and multi-input receptors for precise disease detection, are formally analyzed.
- Published
- 2020
- Full Text
- View/download PDF
24. Diffusion Tensor Imaging of the Superior Thalamic Radiation and Cerebrospinal Fluid Distribution in Idiopathic Normal Pressure Hydrocephalus.
- Author
-
Younes K, Hasan KM, Kamali A, McGough CE, Keser Z, Hasan O, Melicher T, Kramer LA, and Schulz PE
- Subjects
- Aged, Aged, 80 and over, Alzheimer Disease pathology, Diagnosis, Differential, Female, Humans, Hydrocephalus, Normal Pressure pathology, Male, Middle Aged, Pyramidal Tracts diagnostic imaging, Pyramidal Tracts pathology, Thalamus pathology, White Matter pathology, Alzheimer Disease diagnostic imaging, Diffusion Tensor Imaging methods, Hydrocephalus, Normal Pressure diagnostic imaging, Thalamus diagnostic imaging, White Matter diagnostic imaging
- Abstract
Background and Purpose: Ventricular enlargement in elderly raises a challenging differential diagnosis to physicians. While Alzheimer's disease is the most common form of dementia, idiopathic normal pressure hydrocephalus (iNPH) constitutes a potentially reversible syndrome. iNPH has a unique pathophysiology pertaining to cerebrospinal fluid (CSF) dynamics and periventricular white matter. We aimed to determine the effects of iNPH on periventricular white matter bundles and to further characterize its ventricular and sulcal CSF distribution by using diffusion tensor tractography (DTT) and CSF volumetrics on high resolution T1-weighted magnetic resonance imaging data., Methods: Deterministic DTT and validated volumetric parcellation were performed on 20 healthy elderly, 13 Alzheimer's disease (AD), and 9 iNPH patients. The superior thalamic radiation, corticospinal tract, and dentatorubrothalamic tract were traced and quantified using DTI studio software. Cloud-based volumetric parcellation was also performed on 138 healthy subjects across the lifespan, 13 AD, and 9 iNPH-patients. Ventricular and sulcal CSF volumes in the three groups were compared., Results: Combining increased mean diffusivity of the superior thalamic radiation with ventricular volume resulted in clear separation of iNPH from the AD and age-matched healthy subject groups. Additionally, ventricular to sulcal CSF ratio, utilizing fully automated methods, was significantly greater in the iNPH patients compared to AD and healthy age-matched controls., Conclusions: Combined microstructural (DTT) and macrostructural (ventricular volume) changes is a promising radiological approach in studying ventriculomegaly. Automated estimation of the disproportionate ventricular and sulcal CSF ratio in patients presenting with ventriculomegaly may be important as radiologic markers in differentiating iNPH from other causes of ventriculomegaly., (© 2018 by the American Society of Neuroimaging.)
- Published
- 2019
- Full Text
- View/download PDF
25. SmartSIM - a virtual reality simulator for laparoscopy training using a generic physics engine.
- Author
-
Khan ZA, Kamal N, Hameed A, Mahmood A, Zainab R, Sadia B, Mansoor SB, and Hasan O
- Subjects
- Algorithms, Biomechanical Phenomena, Computer Simulation, Computer Systems, Computer-Assisted Instruction instrumentation, Computer-Assisted Instruction statistics & numerical data, Equipment Design, Female, Humans, Male, Physics, Robotic Surgical Procedures education, Robotic Surgical Procedures instrumentation, Robotic Surgical Procedures statistics & numerical data, Software, User-Computer Interface, Computer-Assisted Instruction methods, Laparoscopy education, Virtual Reality
- Abstract
Virtual reality (VR) training simulators have started playing a vital role in enhancing surgical skills, such as hand-eye coordination in laparoscopy, and practicing surgical scenarios that cannot be easily created using physical models. We describe a new VR simulator for basic training in laparoscopy, i.e. SmartSIM, which has been developed using a generic open-source physics engine called the simulation open framework architecture (SOFA). This paper describes the systems perspective of SmartSIM including design details of both hardware and software components, while highlighting the critical design decisions. Some of the distinguishing features of SmartSIM include: (i) an easy-to-fabricate custom-built hardware interface; (ii) use of a generic physics engine to facilitate wider accessibility of our work and flexibility in terms of using various graphical modelling algorithms and their implementations; and (iii) an intelligent and smart evaluation mechanism that facilitates unsupervised and independent learning., (Copyright © 2016 John Wiley & Sons, Ltd.)
- Published
- 2017
- Full Text
- View/download PDF
26. Insurance status and hospital care for myocardial infarction, stroke, and pneumonia.
- Author
-
Hasan O, Orav EJ, and Hicks LS
- Subjects
- Adolescent, Adult, Databases, Factual, Female, Health Care Costs, Healthcare Disparities, Hospital Mortality, Humans, Length of Stay, Male, Middle Aged, Retrospective Studies, United States, Young Adult, Hospitalization, Insurance Coverage statistics & numerical data, Insurance, Health statistics & numerical data, Myocardial Infarction economics, Pneumonia economics, Stroke economics
- Abstract
Background: Despite widely documented variations in health care outcomes by insurance status, few nationally representative studies have examined such disparities in the inpatient setting., Objective: To determine whether there are insurance-related differences in hospital care for 3 common medical conditions., Design and Subjects: Retrospective database analysis of 154,381 adult discharges (age 18-64 years) with a principal diagnosis of acute myocardial infarction (AMI), stroke, or pneumonia from the 2005 Nationwide Inpatient Sample (NIS)., Measurements: For each diagnosis, we compared in-hospital mortality, length of stay (LOS), and cost per hospitalization for Medicaid and uninsured patients with the privately insured., Results: Compared with the privately insured, in-hospital mortality among AMI and stroke patients was significantly higher for the uninsured (adjusted odds ratio [OR] 1.52, 95% confidence interval [CI] [1.24-1.85] for AMI and 1.49 [1.29-1.72] for stroke) and among pneumonia patients was significantly higher for Medicaid recipients (1.21 [1.01-1.45]). Excluding patients who died during hospitalization, LOS was consistently longer for Medicaid recipients for all 3 conditions (adjusted ratio 1.07, 95% CI [1.05-1.09] for AMI, 1.17 [1.14-1.20] for stroke, and 1.04 [1.03-1.06] for pneumonia), although costs were significantly higher for Medicaid recipients for only 2 of the 3 conditions (adjusted ratio 1.06, 95% CI [1.04-1.09] for stroke and 1.05 [1.04-1.07] for pneumonia)., Conclusions: In this nationally representative study of working-age Americans hospitalized for 3 common medical conditions, significantly lower in-hospital mortality was noted for privately insured patients compared with the uninsured or Medicaid recipients. Interventions to reduce insurance-related gaps in inpatient quality of care should be investigated.
- Published
- 2010
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.