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The differential effects of fungicidal applications on the incidence of ozone injury and injury from Atlernaria alternata Fr. Keissel infection on tobacco Nicotiana tabacum L. leaves were investigated. Spray applications of methyl 1-butylcarbamoyl-2-benzimidazolecarbamate (benomyl) were made to two cigar wrapper cultivars, Bel W/sub 3/ and Florida 2612 in the field. Applications of dodecylguanidine acetate (dodine) and manganous ethylenebisdithiocarbamate (maneb) were also observed on tobacco cultivar Bel W/sub 3/. The ozone and A. alternata injuries were observed before and after fungicidal applications. All of the fungicidal applications significantly decreased ozone injury to tobacco leaves. Benomyl was most effective, decreasing leaf injury by 59%. Maneb and dodine were less effective. Maneb significantly decreased brown spot by 66% and benomyl and dodine produced smaller decreases in brown spot. The results demonstrated the differential responses of these two leaf diseases to fungicidal applications. 9 references, 2 tables.