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33 results on '"Harms, Paul W."'

1. Porocarcinomas with PAK1/2/3 fusions: a series of 12 cases

Author

Kervarrec, Thibault, primary, Westphal, Danna, additional, Pissaloux, Daniel, additional, Legrand, Mélanie, additional, Tirode, Franck, additional, Neuhart, Anne, additional, Drouot, Francoise, additional, Becker, Jürgen C, additional, Macagno, Nicolas, additional, Seris, Alice, additional, Jouary, Thomas, additional, Beltzung, Fanny, additional, Jullie, Marie‐Laure, additional, Harms, Paul W, additional, Cribier, Bernard, additional, Mourah, Samia, additional, Jouenne, Fanélie, additional, Fromont, Gaelle, additional, Louveau, Baptiste, additional, Mancini, Maxence, additional, Kazakov, Dmitry V, additional, de la Fouchardière, Arnaud, additional, and Battistella, Maxime, additional

Published
2024
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4. Image‐based multiplex immune profiling of cancer tissues: translational implications. A report of the International Immuno‐oncology Biomarker Working Group on Breast Cancer

Author

Jahangir, Chowdhury Arif, primary, Page, David B, additional, Broeckx, Glenn, additional, Gonzalez, Claudia A, additional, Burke, Caoimbhe, additional, Murphy, Clodagh, additional, Reis‐Filho, Jorge S, additional, Ly, Amy, additional, Harms, Paul W, additional, Gupta, Rajarsi R, additional, Vieth, Michael, additional, Hida, Akira I, additional, Kahila, Mohamed, additional, Kos, Zuzana, additional, van Diest, Paul J, additional, Verbandt, Sara, additional, Thagaard, Jeppe, additional, Khiroya, Reena, additional, Abduljabbar, Khalid, additional, Acosta Haab, Gabriela, additional, Acs, Balazs, additional, Adams, Sylvia, additional, Almeida, Jonas S, additional, Alvarado‐Cabrero, Isabel, additional, Azmoudeh‐Ardalan, Farid, additional, Badve, Sunil, additional, Baharun, Nurkhairul Bariyah, additional, Bellolio, Enrique R, additional, Bheemaraju, Vydehi, additional, Blenman, Kim RM, additional, Botinelly Mendonça Fujimoto, Luciana, additional, Burgues, Octavio, additional, Chardas, Alexandros, additional, Cheang, Maggie Chon U, additional, Ciompi, Francesco, additional, Cooper, Lee AD, additional, Coosemans, An, additional, Corredor, Germán, additional, Dantas Portela, Flavio Luis, additional, Deman, Frederik, additional, Demaria, Sandra, additional, Dudgeon, Sarah N, additional, Elghazawy, Mahmoud, additional, Fernandez‐Martín, Claudio, additional, Fineberg, Susan, additional, Fox, Stephen B, additional, Giltnane, Jennifer M, additional, Gnjatic, Sacha, additional, Gonzalez‐Ericsson, Paula I, additional, Grigoriadis, Anita, additional, Halama, Niels, additional, Hanna, Matthew G, additional, Harbhajanka, Aparna, additional, Hart, Steven N, additional, Hartman, Johan, additional, Hewitt, Stephen, additional, Horlings, Hugo M, additional, Husain, Zaheed, additional, Irshad, Sheeba, additional, Janssen, Emiel AM, additional, Kataoka, Tatsuki R, additional, Kawaguchi, Kosuke, additional, Khramtsov, Andrey I, additional, Kiraz, Umay, additional, Kirtani, Pawan, additional, Kodach, Liudmila L, additional, Korski, Konstanty, additional, Akturk, Guray, additional, Scott, Ely, additional, Kovács, Anikó, additional, Lænkholm, Anne‐Vibeke, additional, Lang‐Schwarz, Corinna, additional, Larsimont, Denis, additional, Lennerz, Jochen K, additional, Lerousseau, Marvin, additional, Li, Xiaoxian, additional, Madabhushi, Anant, additional, Maley, Sai K, additional, Manur Narasimhamurthy, Vidya, additional, Marks, Douglas K, additional, McDonald, Elizabeth S, additional, Mehrotra, Ravi, additional, Michiels, Stefan, additional, Kharidehal, Durga, additional, Minhas, Fayyaz ul Amir Afsar, additional, Mittal, Shachi, additional, Moore, David A, additional, Mushtaq, Shamim, additional, Nighat, Hussain, additional, Papathomas, Thomas, additional, Penault‐Llorca, Frederique, additional, Perera, Rashindrie D, additional, Pinard, Christopher J, additional, Pinto‐Cardenas, Juan Carlos, additional, Pruneri, Giancarlo, additional, Pusztai, Lajos, additional, Rajpoot, Nasir Mahmood, additional, Rapoport, Bernardo Leon, additional, Rau, Tilman T, additional, Ribeiro, Joana M, additional, Rimm, David, additional, Vincent‐Salomon, Anne, additional, Saltz, Joel, additional, Sayed, Shahin, additional, Hytopoulos, Evangelos, additional, Mahon, Sarah, additional, Siziopikou, Kalliopi P, additional, Sotiriou, Christos, additional, Stenzinger, Albrecht, additional, Sughayer, Maher A, additional, Sur, Daniel, additional, Symmans, Fraser, additional, Tanaka, Sunao, additional, Taxter, Timothy, additional, Tejpar, Sabine, additional, Teuwen, Jonas, additional, Thompson, E Aubrey, additional, Tramm, Trine, additional, Tran, William T, additional, van der Laak, Jeroen, additional, Verghese, Gregory E, additional, Viale, Giuseppe, additional, Wahab, Noorul, additional, Walter, Thomas, additional, Waumans, Yannick, additional, Wen, Hannah Y, additional, Yang, Wentao, additional, Yuan, Yinyin, additional, Bartlett, John, additional, Loibl, Sibylle, additional, Denkert, Carsten, additional, Savas, Peter, additional, Loi, Sherene, additional, Specht Stovgaard, Elisabeth, additional, Salgado, Roberto, additional, Gallagher, William M, additional, and Rahman, Arman, additional

Published
2024
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6. CD30 expression in cutaneous B‐cell lymphomas

Author

Afolayan‐Oloye, Olabisi, primary, Zhao, Lili, additional, Tejasvi, Trilokraj, additional, Chan, May P., additional, Harms, Paul W., additional, Fullen, Douglas R., additional, Wilcox, Ryan A., additional, and Hristov, Alexandra C., additional

Published
2023
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10. Cover Image

Author

Dunstan, Robert W., primary, Salte, Katherine M., additional, Todorović, Viktor, additional, Lowe, Margaret, additional, Wetter, Joseph B., additional, Harms, Paul W., additional, Burney, Richard E., additional, Scott, Victoria E., additional, Smith, Kathleen M., additional, Rosenblum, Michael D., additional, Gudjonsson, Johann E., additional, and Honore, Prisca, additional

Published
2021
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13. Histologic progression of acne inversa/hidradenitis suppurativa: Implications for future investigations and therapeutic intervention

Author

Dunstan, Robert W., primary, Salte, Katherine M., additional, Todorović, Viktor, additional, Lowe, Margaret, additional, Wetter, Joseph B., additional, Harms, Paul W., additional, Burney, Richard E., additional, Scott, Victoria E., additional, Smith, Kathleen M., additional, Rosenblum, Michael D., additional, Gudjonsson, Johann E., additional, and Honore, Prisca, additional

Published
2021
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17. A pediatric case of pigmented epithelioid melanocytoma with chromosomal copy number alterations in 15q and 17q and a novel NTRK3‐SCAPER gene fusion

Author

Friedman, Ben J., primary, Hernandez, Simon, additional, Fidai, Chelsea, additional, Jiang, Angela, additional, Shwayder, Tor A., additional, Carskadon, Shannon, additional, Andea, Aleodor A., additional, Harms, Paul W., additional, Chitale, Dhananjay, additional, and Palanisamy, Nallasivam, additional

Published
2019
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29. A case of NONO::TFE3 cutaneous epithelioid and spindle cell tumor with local recurrence after complete excision.

Author

Durgin JS, Smith EH, Harms PW, Brown NA, and Chan MP

Subjects
Humans, Female, Middle Aged, Biomarkers, Tumor metabolism, Oncogene Proteins, Fusion genetics, Skin Neoplasms pathology, Skin Neoplasms metabolism, Skin Neoplasms genetics, Neoplasm Recurrence, Local pathology, Neoplasm Recurrence, Local metabolism, Basic Helix-Loop-Helix Leucine Zipper Transcription Factors genetics, Basic Helix-Loop-Helix Leucine Zipper Transcription Factors metabolism
Abstract

Mesenchymal tumors may display morphologic and immunohistochemical overlap with melanocytic tumors, presenting a pitfall for misdiagnosis. We report a 62-year-old woman who presented with a recurrent dermal and subcutaneous tumor over the Achilles tendon 15 years following complete excision. Both the primary and the recurrent tumors were characterized by nests and sheets of epithelioid and spindle cells with eosinophilic cytoplasm and uniform ovoid nuclei. The tumor was positive for S100, SOX10, HMB45, cathepsin K, and p63 (weak), while negative for Melan-A, MiTF, smooth muscle actin, and desmin. Gene fusion analysis of the recurrent tumor revealed a NONO::TFE3 fusion which has been recently reported in two similar cutaneous cases. Our case highlights the potential of a NONO::TFE3 cutaneous epithelioid and spindle cell tumor to recur after a prolonged disease-free interval without evidence of high-grade transformation or distant metastasis. Our findings support its classification as a cutaneous mesenchymal neoplasm of intermediate malignancy., (© 2024 The Author(s). Journal of Cutaneous Pathology published by John Wiley & Sons Ltd.)

Published
2024
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30. MAP2K1-mutated melanocytic tumors have reproducible histopathologic features and share similarities with melanocytic tumors with BRAF V600E mutations.

Author

Alomari AK, Harms PW, Andea AA, and Warren SJ

Subjects
Female, Humans, Male, Proto-Oncogene Proteins B-raf genetics, Retrospective Studies, Ultraviolet Rays, Chromosome Aberrations, MAP Kinase Kinase 1 genetics, Melanoma pathology, Skin Neoplasms pathology, Nevus, Epithelioid and Spindle Cell genetics
Abstract

Background: Melanocytic tumors driven by MAP2K1 in-frame deletions are among the most recently described class of melanocytic neoplasms. The reported range of diagnoses and associated genomic aberrations in these neoplasms is wide and includes melanomas, deep penetrating melanocytomas, and pigmented epithelioid melanocytoma. However, little is known about the characteristics of these tumors, especially in the absence of well-known second molecular "hits." Moreover, despite their frequent spitzoid cytomorphology, their potential categorization among the Spitz tumors is debatable., Materials and Methods: We conducted a retrospective search through our molecular archives to identify sequenced melanocytic tumors with MAP2K1 in-frame deletions. We reviewed the clinical and histomorphological features of these tumors and compared them to similar neoplasms reported to date. In addition, we performed single-nucleotide polymorphism (SNP) array testing to identify structural chromosomal aberrations., Results: Of 27 sequenced tumors, 6 (22%) showed a pathogenic MAP2K1 in-frame deletion (with or without insertion) and were included in this series. Five (83%) were females with lesions involving the upper limb. Histopathologically, all neoplasms were compounded with plaque-like or wedge-shaped silhouettes, spitzoid cytomorphology, and impaired cytologic maturation. All cases showed background actinic damage with sclerotic stroma replacing solar elastosis, variable pagetoid scatter, and occasional dermal mitotic figures (range 1-2/mm 2 ). Five cases (83%) had a small component of nevic-looking melanocytes. Biologically, these tumors likely fall within the spectrum of unusual nevi. Five cases (83%) had a relatively high mutational burden and four (67%) showed an ultraviolet radiation signature. Four cases (67%) showed in-frame deletion involving the p.I103_K104del locus while two cases (33%) showed in-frame deletion involving the p.Q58_E62del locus. SNP array testing showed structural abnormalities ranging from 1 to 5 per case. Five of these cases showed a gain of chromosome 15 spanning the MAP2K1 gene locus., Discussion and Conclusion: Melanocytic tumors with MAP2K1 in-frame deletion could represent another spectrum of melanocytic tumors with close genotypic-phenotypic correlation. They are largely characterized by a spectrum that encompasses desmoplastic Spitz nevus as shown in our series and Spitz and Clark nevus as shown by others. Evolutionary, they share many similarities with tumors with BRAF V600E mutations, suggesting they are better classified along the conventional pathway rather than the Spitz pathway despite the frequent spitzoid morphology., (© 2023 The Authors. Journal of Cutaneous Pathology published by John Wiley & Sons Ltd.)

Published
2023
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31. Cutaneous follicle center lymphomas with plasmacytic differentiation.

Author

Skala SL, Harms PW, Fullen DR, Brown NA, Tejasvi T, Wilcox RA, Boyer DF, and Hristov AC

Subjects
Adult, Aged, Biopsy, Cell Differentiation, Female, Humans, Immunoglobulin lambda-Chains metabolism, Immunophenotyping methods, Lymphoma, B-Cell pathology, Lymphoma, Follicular surgery, Lymphoma, Follicular ultrastructure, Male, Middle Aged, Plasma Cells metabolism, Treatment Outcome, Immunoglobulin kappa-Chains metabolism, Lymphoma, B-Cell diagnosis, Lymphoma, Follicular diagnosis, Plasma Cells pathology, Skin Neoplasms pathology
Abstract

Follicle center lymphomas, including primary cutaneous follicle center lymphoma (PCFCL), may rarely show plasmacytic differentiation. Such cases can pose a diagnostic challenge and can be mistaken for other lymphomas that more commonly include plasma cells. Here, we report four cases of PCFCL and one case of systemic follicular lymphoma involving the skin with associated monotypic plasma cells, including the clinical, morphologic and immunophenotypic features., (© 2020 John Wiley & Sons A/S . Published by John Wiley & Sons Ltd.)

Published
2021
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32. Expression of p16 in Merkel cell carcinoma.

Author

Talsma CE, Wang M, Andea AA, Fullen DR, Harms PW, and Chan MP

Subjects
Biomarkers, Tumor immunology, Carcinoma, Merkel Cell diagnosis, Carcinoma, Squamous Cell diagnosis, Carcinoma, Squamous Cell pathology, Diagnosis, Differential, Humans, Immunohistochemistry methods, Papillomavirus Infections complications, Carcinoma, Merkel Cell metabolism, Carcinoma, Merkel Cell pathology, Carcinoma, Squamous Cell metabolism, Cyclin-Dependent Kinase Inhibitor p16 metabolism, Skin Neoplasms pathology
Published
2021
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33. A pediatric case of pigmented epithelioid melanocytoma with chromosomal copy number alterations in 15q and 17q and a novel NTRK3-SCAPER gene fusion.

Author

Friedman BJ, Hernandez S, Fidai C, Jiang A, Shwayder TA, Carskadon S, Andea AA, Harms PW, Chitale D, and Palanisamy N

Subjects
Child, Preschool, Female, Humans, Skin Neoplasms genetics, Skin Neoplasms metabolism, Skin Neoplasms pathology, Carrier Proteins genetics, Carrier Proteins metabolism, Chromosome Aberrations, Chromosomes, Human, Pair 15 genetics, Chromosomes, Human, Pair 15 metabolism, Chromosomes, Human, Pair 17 genetics, Chromosomes, Human, Pair 17 metabolism, Discoidin Domain Receptor 2 genetics, Discoidin Domain Receptor 2 metabolism, Head and Neck Neoplasms genetics, Head and Neck Neoplasms metabolism, Head and Neck Neoplasms pathology, Nevus, Blue genetics, Nevus, Blue metabolism, Oncogene Proteins, Fusion
Abstract

Pigmented epithelioid melanocytoma (PEM) represents a group of rare, heavily pigmented melanocytic tumors encompassing lesions previously designated as "animal-type melanomas" and "epithelioid blue nevi." Despite the association of multiple such tumors in the setting of Carney complex, most cases of PEM occur spontaneously as solitary neoplasms in otherwise healthy patients. PEM may arise in both children and adults, and has a known propensity to spread to the regional lymph nodes. Despite this latter finding, recurrence at the biopsy site or spread beyond the lymph node basin is exceptionally uncommon. Although the molecular basis for PEM continues to be characterized, findings to date suggest that this category of melanocytic neoplasia has genetic alterations distinct from those seen in common nevi, dysplastic nevi, Spitz nevi, and melanoma. Herein, we present an in-depth clinical, histopathologic, and molecular analysis of a case of PEM occurring on the scalp of a young African American girl found to have a novel NTRK3-SCAPER gene fusion., (© 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)

Published
2020
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