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37 results on '"Hamza, S."'

4. Bio‐inspired synthesis of AgNPs from lichen as potential antibacterial and mosquito larvicidal activity with negligible toxicity onGambusia affinis

Author

Loganathan, Kalimuthu, primary, Chellamuthu, Vasugi, additional, Karupuswami, Dhanalakshmi, additional, Mohan, Kannan, additional, Suresh, Udaiyan, additional, Panneerselvam, Chellasamy, additional, Trivedi, Subrata, additional, Aziz, Al Thabiani, additional, Alatawi, Fuad A., additional, Munshi, Alaa M., additional, Al‐Aoh, Hatem A., additional, Al‐Shehri, Hamza S., additional, and Alhawiti, Aliyah S., additional

Published
2023
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8. Bovine serum albumin functionalized blue emitting Ti3C2 MXene quantum dots as a sensitive fluorescence probe for Fe3+ ion detection and its toxicity analysis

Author

Al‐Duais, Mohammed Ali, primary, Mohammedsaleh, Zuhair M., additional, Al‐Shehri, Hamza S., additional, Al‐Awthan, Yahya S., additional, Bani‐Atta, Suhair A., additional, Keshk, Ali A., additional, Mustafa, Syed Khalid, additional, Althaqafy, Adel D., additional, Al‐Tweher, Jozaa N., additional, Al‐Aoh, Hatem A., additional, and Panneerselvam, Chellasamy, additional

Published
2022
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9. BCR‐NTRK2 fusion in a pediatric patient with spinal gangliocytoma

Author

Avanti Gupte, Neena I. Marupudi, Swati Mody, William J. Kupsky, and Hamza S Gorsi

Subjects
Oncology, medicine.medical_specialty, Pediatric patient, Text mining, business.industry, Internal medicine, Pediatrics, Perinatology and Child Health, medicine, breakpoint cluster region, Hematology, business, Gangliocytoma
Published
2021

13. A novel finding in pediatric leiomyosarcoma: Expanding spectrum of FGFR rearrangements in childhood cancers

Author

Yogindra Persaud, Shruti Bagla, Yaddanapudi Ravindranath, Christina Shanti, Hamza S Gorsi, and Bahig M. Shehata

Subjects
Oncology, Leiomyosarcoma, Chemotherapy, medicine.medical_specialty, business.industry, medicine.medical_treatment, Pediatric age, Hematology, Gene rearrangement, medicine.disease, body regions, Fibroblast growth factor receptor, Internal medicine, Pediatrics, Perinatology and Child Health, medicine, Rhabdomyosarcoma, business, Pediatric population
Abstract

Non Rhabdomyosarcoma Soft Tissue Sarcomas (NRSTS) are rare in the pediatric age group, accounting for 1-7% of all pediatric tumors. Leiomyosarcoma, a subtype of NRSTS, is exceedingly rare in pediatric population. Due to the rarity of this condition, management is extrapolated from other common NRSTS which involves surgery, chemotherapy and radiation. Chemotherapy is not very effective in management of pediatric leiomyosarcoma and molecular information may help guide targeted therapies. We describe a patient with a FGFR1-TACC1 gene rearrangement which, based on other models, predicts for sensitivity to FGFR inhibitors.

Published
2020

19. Plasminogen activator inhibitor-1 does not contribute to the pulmonary pathology induced by acute exposure to ozone

Author

Elkhidir, Hamza S., primary, Richards, Jeremy B., additional, Cromar, Kevin R., additional, Bell, Cynthia S., additional, Price, Roger E., additional, Atkins, Constance L., additional, Spencer, Chantal Y., additional, Malik, Farhan, additional, Alexander, Amy L., additional, Cockerill, Katherine J., additional, Haque, Ikram U., additional, and Johnston, Richard A., additional

Published
2016
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21. Plasminogen activator inhibitor-1 does not contribute to the pulmonary pathology induced by acute exposure to ozone

Author

Chantal Y. Spencer, Kevin R. Cromar, Richard A. Johnston, Hamza S. Elkhidir, Katherine J. Cockerill, Roger E. Price, Amy L. Alexander, Constance L. Atkins, Jeremy B. Richards, Cynthia S. Bell, Farhan Malik, and Ikram U. Haque

Subjects
0301 basic medicine, medicine.medical_specialty, Physiology, medicine.medical_treatment, Immunology, Lung injury, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Airway hyperresponsiveness, Physiology (medical), Internal medicine, Fibrinolysis, Medicine, Respiratory Physiology, lung injury, macrophage inflammatory protein‐2, Macrophage inflammatory protein, Original Research, Lung, medicine.diagnostic_test, business.industry, epithelial cell, neutrophil, Interleukin, 3. Good health, 030104 developmental biology, Bronchoalveolar lavage, Endocrinology, medicine.anatomical_structure, 030228 respiratory system, chemistry, Plasminogen activator inhibitor-1, business, Toxins, Pollutants and Chemical Agents, Plasminogen activator
Abstract

Expression of plasminogen activator inhibitor (PAI)‐1, the major physiological inhibitor of fibrinolysis, is increased in the lung following inhalation of ozone (O3), a gaseous air pollutant. PAI‐1 regulates expression of interleukin (IL)‐6, keratinocyte chemoattractant (KC), and macrophage inflammatory protein (MIP)‐2, which are cytokines that promote lung injury, pulmonary inflammation, and/or airway hyperresponsiveness following acute exposure to O3. Given these observations, we hypothesized that PAI‐1 contributes to the severity of the aforementioned sequelae by regulating expression of IL‐6, KC, and MIP‐2 following acute exposure to O3. To test our hypothesis, wild‐type mice and mice genetically deficient in PAI‐1 (PAI‐1‐deficient mice) were acutely exposed to either filtered room air or O3 (2 ppm) for 3 h. Four and/or twenty‐four hours following cessation of exposure, indices of lung injury [bronchoalveolar lavage fluid (BALF) protein and epithelial cells], pulmonary inflammation (BALF IL‐6, KC, MIP‐2, macrophages, and neutrophils), and airway responsiveness to aerosolized acetyl‐β‐methylcholine chloride (respiratory system resistance) were measured in wild‐type and PAI‐1‐deficient mice. O3 significantly increased indices of lung injury, pulmonary inflammation, and airway responsiveness in wild‐type and PAI‐1‐deficient mice. With the exception of MIP‐2, which was significantly lower in PAI‐1‐deficient as compared to wild‐type mice 24 h following cessation of exposure to O3, no other genotype‐related differences occurred subsequent to O3 exposure. Thus, following acute exposure to O3, PAI‐1 neither regulates pulmonary expression of IL‐6 and KC nor functionally contributes to any of the pulmonary pathological sequelae that arise from the noxious effects of inhaled O3.

Published
2016

37. Giant basal cell carcinoma associated with human papillomaviruses infection.

Author

Northington M, Tamburin L, Hamza S, Diwan H, Skelton H, and Smith K

Subjects
Biomarkers, Tumor analysis, Carcinoma, Basal Cell chemistry, Carcinoma, Basal Cell pathology, Cell Division, Fatal Outcome, Humans, Male, Middle Aged, Papillomaviridae classification, Papillomavirus Infections complications, Papillomavirus Infections pathology, Proto-Oncogene Proteins c-bcl-2 metabolism, Skin Neoplasms chemistry, Skin Neoplasms pathology, Tumor Suppressor Protein p53 metabolism, Carcinoma, Basal Cell virology, Papillomaviridae isolation & purification, Papillomavirus Infections virology, Skin Neoplasms virology
Abstract

Different criteria have been used to define giant basal cell carcinoma (BCC). However, the majority of tumors of 10 cm or greater in diameter have a characteristic clinical and histopathologic presentation. As a group, these tumors often show metastatic spread as opposed to all other BCCs that rarely metastasize. We present an additional patient with a giant BCC greater than 100 cm2. This tumor had a characteristic location and infiltrative growth pattern. Unusual features of this tumor included a lack of expression of BCL-2 with a greater proportion of cycling tumor cells expressing proliferation markers than conventional BCC, as well as expression of anogenital human papillomaviruses (HPV) subtypes with oncogenic potential. The association of HPV with BCCs has rarely been studied and may not be identical to HPV-induced genital squamous cell carcinomas. However, the findings in this patient suggest that HPV may play a role in the development of some chronic giant BCCs.

Published
2004
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