Search

Your search keyword '"Halmagyi G M"' showing total 16 results
Start Over Author "Halmagyi G M" Publisher wiley
16 results on '"Halmagyi G M"'

16. Gentamicin vestibulotoxicity.

Author

Halmagyi GM, Fattore CM, Curthoys IS, and Wade S

Subjects
Adult, Aged, Aged, 80 and over, Female, Gentamicins administration & dosage, Gentamicins blood, Humans, Infusions, Intravenous, Injections, Intramuscular, Kidney Diseases chemically induced, Kidney Diseases complications, Male, Middle Aged, Vestibular Diseases complications, Gentamicins adverse effects, Vestibular Diseases chemically induced
Abstract

We reviewed 36 patients with gentamicin vestibulotoxicity to determine its relationship to gentamicin dosage, serum gentamicin levels, and the development of gentamicin nephrotoxicity. Thirty of the patients had received intravenous or intramuscular gentamicin; six had received intraperitoneal gentamicin. Sixteen of the 30 patients treated with intramuscular or intravenous gentamicin had received less than the recommended maximum dose of 5 mg/kg/day for less than the recommended maximum period of 10 days. Nephrotoxicity as well as vestibulotoxicity developed in 16 of these 30 patients. Gentamicin vestibulotoxicity was not recognized before discharge from hospital in 32 of the 36 patients. We conclude that as far as the vestibular system is concerned there is no safe gentamicin dose and no safe serum gentamicin level, and there is an increased risk of vestibulotoxicity in patients in whom nephrotoxicity develops. Physicians who use gentamicin should become more aware of the clinical features of vestibulotoxicity because stopping gentamicin as soon as symptoms of vestibulotoxicity appear could prevent permanent impairment of vestibular function.

Published
1994
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results