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Your search keyword '"Hai-Xiang Chen"' showing total 2 results
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2 results on '"Hai-Xiang Chen"'

1. Resistance Theory of General 2 × n Resistor Networks

Author

Zhi-Zhong Tan, Xin-Yu Fang, Ming-Yue Wang, Hai-Xiang Chen, Xuan Hu, Yi‐Tian Zhang, and Wan-Jiao Chen

Subjects
Statistics and Probability, Physics, Numerical Analysis, Multidisciplinary, Equivalent series resistance, Resistance (ecology), Differential equation, law, Modeling and Simulation, Mathematical analysis, Resistor, law.invention
Published
2021
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2. Overexpression of degenerative spermatocyte homolog 1 up-regulates the expression of cyclin D1 and enhances metastatic efficiency in esophageal carcinoma Eca109 cells

Author

Dong Xie, Zhi-Jian Sun, Xiao-Dan Ji, Xiaolei Ye, Wu Zhou, and Hai-Xiang Chen

Subjects
Fatty Acid Desaturases, Cancer Research, Cell cycle checkpoint, Esophageal Neoplasms, Cyclin D, Blotting, Western, Cyclin B, Fluorescent Antibody Technique, Mice, Nude, Transfection, Mice, Cyclin D1, Cell Movement, Tumor Cells, Cultured, Animals, Humans, Gene Silencing, RNA, Messenger, Neoplasm Metastasis, RNA, Small Interfering, Luciferases, Molecular Biology, Transcription factor, Cell Proliferation, Gene knockdown, biology, Reverse Transcriptase Polymerase Chain Reaction, Cell Cycle, NF-kappa B, Cell migration, Cadherins, Up-Regulation, Cell biology, Gene Expression Regulation, Neoplastic, biology.protein, Cancer research, Cyclin A2
Abstract

Cyclin D1 plays a pivotal role in cell-cycle transition through G1 phase. In this article, we found that Degenerative Spermatocyte Homolog 1 (DEGS1) up-regulated the expression of cyclin D1 and the activation of transcription factor NF-κB was essential for DEGS1-induced cyclin D1 production. Forced expression of DEGS1 in Esophageal carcinoma cell line Eca109 cells increased their ability of cell migration and significantly induced tumor metastasis in nude mice, whereas RNA interference-mediated knockdown of DEGS1 cells significantly inhibited cell migration in vitro, as well as tumor metastasis in vivo. Our results demonstrated that expression of DEGS1 up-regulated the expression of cyclin D1 and enhanced the efficiency of tumor metastasis. © 2009 Wiley-Liss, Inc.

Published
2009
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