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1. Forage yield and nutritive value of plantain and chicory for livestock feed at high altitudes in Peru

Author

Luis A. Vallejos‐Fernández, Ricardo Guillén, César Pinares‐Patiño, Rubén García‐Ticllacuri, Yudith Y. Muñoz‐Vilchez, Carlos Quilcate, and Wuesley Y. Alvarez‐García

Subjects
Cichorium intybus L., dry matter yield, high‐altitude environments, nutritive value, Plantago lanceolata L., Agriculture (General), S1-972, Plant culture, SB1-1110
Abstract

Abstract Background Evaluation of forage resources is vital for the sustainability of livestock farming in the South American Andes, especially under conditions of low water availability for irrigation and acid soils. Methods We evaluated the productivity and nutritive value of two cultivars of chicory (Cichorium intybus L.) and one of plantain (Plantago lanceolata L.) in three high‐altitude sites (AL) of the northern highlands of Peru: AL‐I: 2300–2800 m.a.s.l, AL‐II: 2801–3300 m.a.s.l. and AL‐III: 3301–3800 m.a.s.l., for 1 year. The parameters evaluated were dry matter yield (DMY), plant height (PH), growth rate (GR) and nutritional value. Results Plantain achieved the greatest annual DMY (ADMY), PH and GR compared to the two chicory cultivars (9.34, 9.56 and 13.39 Mg ha−1 for Puna II and Sese 100 chicory and Tonic plantain, respectively; p = 0.0019). The greatest ADMY and GR occurred at AL‐I. Regarding nutritional value, differences were observed only for in vitro digestibility of dry matter and metabolisable energy with chicory cultivars higher than plantain. Conclusions The results indicate that the three cultivars evaluated may be used as a nutritional supplement in cattle feed, associated with grasses because they have high nutritive value suitable for milk production in the mountain regions of Peru.

Published
2024
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2. Cardiogenic Shock Complicating Takotsubo Syndrome: Sex‐Related Differences

Author

Marco Tomasino, Iván J. Núñez‐Gil, Manuel Martínez‐Selles, Oscar Vedia, Miguel Corbí‐Pascual, Jorge Salamanca, Emilia Blanco‐Ponce, Clara Fernández Cordón, Manuel Almendro‐Delia, Alberto Pérez‐Castellanos, Agustín Martín‐García, Sofía Vila‐Sanjuán, Ravi Vazirani, Albert Duran‐Cambra, Victor M. Becerra‐Muñoz, Marta Guillén‐Marzo, and Aitor Uribarri

Subjects
cardiogenic shock, heart failure, prognosis, sex, Takotsubo, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Background Sex‐related differences in Takotsubo syndrome have been described, but no information is available in patients who develop cardiogenic shock. Methods and Results Of 412 patients with Takotsubo syndrome with cardiogenic shock, 71 (17.2%) were men. Male patients were older (71.1±12.2 versus 65.3±17.1 years, P

Published
2024
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3. Long‐term secukinumab efficacy and safety in bio‐naïve patients with moderate‐to‐severe cutaneous psoriasis: A real‐world retrospective noninterventional multicentric experience (128 patients)

Author

Francisco Javier Melgosa Ramos, Almudena Mateu Puchades, Santiago Guillén Climent, Marta Galarreta Pascual, Marina Saéz Belló, María Angels Martínez Ferrer, Fernando Toledo Alberola, Jorge Magdaleno Tapial, Jose Luís Sánchez Carazo, Javier Matáix Díaz, Luca Schneller‐Pavelescu Apetrei, Laura García Fernández, Iris González Villanueva, Isabel Belinchón Romero, Sergio Martín Jiménez, and Sergio Santos Alarcón

Subjects
bio‐naïve, IL‐17 inhibitors, psoriasis, real‐world experience, secukinumab, Dermatology, RL1-803, Diseases of the genitourinary system. Urology, RC870-923
Abstract

Abstract Background There is limited evidence over the real‐life secukinumab survival in psoriatic patients, especially in the long‐term bio‐naïve subjects, and to date biological treatments have been assessed in patients with a chronic and recalcitrant psoriasis. It has been hypothesised that early intensive treatment with biological therapies could decrease pathogenic tissue resident memory (TRm) cells migration and potentially modify the natural course of psoriasis and related comorbidities. Objectives To analyze long‐term secukinumab efficacy, safety and survival, and its predictive factors for psoriasis treatment determining also whether early intervention may result in better outcomes for patients. Methods Bio‐naïve psoriatic patients under treatment with secukinumab (n = 128 patients) in a daily practice setting were analyzed in a retrospective multicentric study and followed up to 8 years. Drug survival rate, efficacy, posology and safety were reported. Results The overall secukinumab survival was 81.9% for an average treatment exposure of 147.9 weeks. The approved posology was the most commonly prescribed regimen (78.7%), and 17.7% could be optimized. An absolut‐PASI ≤3 was reached by 86.6%, 82.6% and 91.7% at the weeks 48,156 and 264, respectively. The incidence of arthritis or psoriasis related comorbidities was low. The response was not influenced by weight, age (>65), gender or the presence of arthritis. No severe adverse events were reported. Conclusions In our bio‐naïve series, the high efficacy and long‐term survival rates observed and the low prevalence of arthritis and comorbidities might suggest that early intervention could contribute to modify the course of the disease, but further studies are needed.

Published
2023
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4. Prognostic Utility of Society for Cardiovascular Angiography and Interventions Shock Stage Approach for Classifying Cardiogenic Shock Severity in Takotsubo Syndrome

Author

Andrea Camblor‐Blasco, Ivan J. Nuñez‐Gil, Albert Duran Cambra, Manuel Almendro‐Delia, Eduard Ródenas‐Alesina, Clara Fernández‐Cordon, Oscar Vedia, Miguel Corbí‐Pascual, Emilia Blanco‐Ponce, Sergio Raposeiras‐Roubin, Marta Guillén Marzo, Alejandro Sanchez Grande Flecha, Jose Maria Garcia Acuña, Jorge Salamanca, Juan M. Escudier‐Villa, Agustin C. Martin‐Garcia, Marco Tomasino, Ravi Vazirani, Alberto Perez‐Castellanos, and Aitor Uribarri

Subjects
cardiogenic shock, extracorporeal membrane oxygenation, heart failure, SCAI, Takotsubo syndrome, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Background Cardiogenic shock (CS) is a significant complication of Takotsubo syndrome (TTS), contributing to heightened mortality and morbidity. Despite this, the Society for Cardiovascular Angiography and Interventions (SCAI) staging system for CS severity lacks validation in patients with TTS and CS. This study aimed to characterize a patient cohort with TTS using the SCAI staging system and assess its utility in cases of TTS complicated by CS. Methods and Results From a TTS national registry, 1591 consecutive patients were initially enrolled and stratified into 5 SCAI stages (A through E). Primary outcome was all‐cause in‐hospital mortality; secondary end points were TTS‐related in‐hospital complications and 1‐year all‐cause mortality. After exclusions, the final cohort comprised 1163 patients, mean age 71.0±11.8 years, and 87% were female. Patients were categorized across SCAI shock stages as follows: A 72.1%, B 12.2%, C 11.2%, D 2.7%, and E 1.8%. Significant variations in baseline demographics, comorbidities, clinical presentations, and in‐hospital courses were observed across SCAI shock stages. After multivariable adjustment, each higher SCAI shock stage showed a significant association with increased in‐hospital mortality (adjusted odds ratio: 1.77–29.31) compared with SCAI shock stage A. Higher SCAI shock stages were also associated with increased 1‐year mortality. Conclusions In a large multicenter patient cohort with TTS, the functional SCAI shock stage classification effectively stratified mortality risk, revealing a continuum of escalating shock severity with higher stages correlating with increased in‐hospital mortality. This study highlights the applicability and prognostic value of the SCAI staging system in TTS‐related CS.

Published
2024
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5. Metagenomic analysis of plant viruses in tropical fresh and wastewater

Author

Alexander Lopez‐Roblero, David José Martínez Cano, Elia Diego‐García, Griselda Karina Guillén‐Navarro, Pavel Iša, and Eugenia Zarza

Subjects
freshwater, metagenomic, tobamovirus, viral ecology, wastewater, Environmental sciences, GE1-350, Microbial ecology, QR100-130
Abstract

Abstract Due to considerable losses in the agricultural sector, phytopathogenic viruses are of significant economic importance. Several phytopathogenic viruses have been detected in water bodies. These can be transmitted to their hosts through water contact. However, relatively few studies concentrate on the presence and impact of plant‐infecting viruses in water environments. In the present study, we used a metagenomic approach to determine viral phytopathogen diversity in wastewater, freshwater, and sludge from the southernmost tropical region in Mexico. We detected 15 different phytopathogenic viruses that belonged to the family Virgaviridae, genus Tobamovirus. Pepper mild mottle virus, tomato brown rugose fruit virus, and tropical soda apple mosaic virus had the highest number of reads. Phylogenetic analysis of the coat protein (CP) amino acid sequence revealed a close relationship between the solanaceous plant‐infecting viruses and the reference sequences found in GenBank. On the other hand, the CP amino acid sequence of Fabaceae and Cucurbitaceae‐infecting viruses did not show such a close relationship when compared with GenBank reference sequences. These results suggested that detected viral sequences could originate from new strains or species of local viruses likely from the consumption of locally cultivated produce, whereas those infecting solanaceous plants might come from consumption of processed or imported food to Mexico. The prevalence of a high diversity of plant viruses in wastewater and rivers and their potential infectivity raise concerns about the use of contaminated freshwater and wastewater in agriculture in Mexico.

Published
2024
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6. Early‐onset Alzheimer's disease shows a distinct neuropsychological profile and more aggressive trajectories of cognitive decline than late‐onset

Author

Adrià Tort‐Merino, Neus Falgàs, Isabel E. Allen, Mircea Balasa, Jaume Olives, José Contador, Magdalena Castellví, Jordi Juncà‐Parella, Núria Guillén, Sergi Borrego‐Écija, Bea Bosch, Guadalupe Fernández‐Villullas, Oscar Ramos‐Campoy, Anna Antonell, Lorena Rami, Raquel Sánchez‐Valle, and Albert Lladó

Subjects
Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429
Abstract

Abstract Objectives Early‐ and late‐onset Alzheimer's disease (EOAD and LOAD) share the same neuropathological traits but show distinct cognitive features. We aimed to explore baseline and longitudinal outcomes of global and domain‐specific cognitive function in a well characterized cohort of patients with a biomarker‐based diagnosis. Methods In this retrospective cohort study, 195 participants were included and classified according to their age, clinical status, and CSF AD biomarker profile: 89 EOAD, 37 LOAD, 46 young healthy controls (age ≤ 65 years), and 23 old healthy controls (>65 years). All subjects underwent clinical and neuropsychological assessment, neuroimaging, APOE genotyping and lumbar puncture. Results We found distinct neuropsychological profiles between EOAD and LOAD at the time of diagnosis. Both groups showed similar performances on memory and language domains, but the EOAD patients displayed worsened deficits in visual perception, praxis, and executive tasks (p

Published
2022
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7. PB2270: PROGNOSTIC VALUE OF INTERIM POSITRON EMISSION TOMOGRAPHY IN HIGH-TUMOR-BURDEN FOLLICULAR LYMPHOMA

Author

Marta Mora Argumánez, Rocio Perez, Beatriz Alvarez Padilla, María Irene Nuevo López, Angela Gil, Dolores Subirá Pérez, Ana Belén Santos Montero, Nuria Golbano, Helga Guillén García, Alejandro Vazquez Ramo, Sonia Herrero Martín, Laura Moreno, Jaime Arbeteta Juanis, María Dolores Morales Sanz, and Dunia De Miguel Llorente

Subjects
Diseases of the blood and blood-forming organs, RC633-647.5
Published
2023
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8. PB2628: EXPERIENCE AT THE GUADALAJARA UNIVERSITY HOSPITAL (SPAIN) IN FETAL AND NEONATAL ALLOINMUNE THROMBOCYTOPENIA (FNAIT) DURING EIGHT YEARS.

Author

María Irene Nuevo López, Marta Mora Argumanez, Mª Dolores Morales Sanz, Rocio Perez Alonso, Beatriz Álvarez Padilla, Ángela Gil Pérez, Helga Guillén García, Alejandro Vazquez Ramo, Berta Mercedes Michael Fernandez, Nuria Golbano López, Sonia Herrero, Jaime Arbeteta Juanis, and Dunia de Miguel Llorente

Subjects
Diseases of the blood and blood-forming organs, RC633-647.5
Published
2023
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9. PB2687: DIGITAL-HEALTH AND REMOTE MONITORING FOR PATIENTS RECEIVING AZACITIDINE AT HOME. A FURTHER STEP TOWARDS HUMANIZATION AND PATIENT-CENTERED MEDICINE

Author

Isabel Gonzalez-Gascon-Y-Marin, María Mir, Alejandro Santiago, Maria Angeles Foncillas Garcia, Teresa Osorio, Francisco-José Ruiz-Gómez, Maria José Solaeta, Victorino Diez, Nuria Suarez-Liceras, Carlos Bibiano-Guillén, and Jose Ángel Hernández Rivas

Subjects
Diseases of the blood and blood-forming organs, RC633-647.5
Published
2023
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10. Gene expression profiles of breast cancer metastasis according to organ site

Author

Fara Brasó‐Maristany, Laia Paré, Nuria Chic, Olga Martínez‐Sáez, Tomás Pascual, Meritxell Mallafré‐Larrosa, Francesco Schettini, Blanca González‐Farré, Esther Sanfeliu, Débora Martínez, Patricia Galván, Esther Barnadas, Belinda Salinas, Pablo Tolosa, Eva Ciruelos, Esther Carcelero, Cecilia Guillén, Barbara Adamo, Reinaldo Moreno, Maria Vidal, Montserrat Muñoz, and Aleix Prat

Subjects
breast cancer, gene expression profiling, HER2‐low, metastatic sites, PAM50, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

In advanced breast cancer, biomarker identification and patient selection using a metastatic tumor biopsy is becoming more necessary. However, the biology of metastasis according to the organ site is largely unknown. Here, we evaluated the expression of 771 genes in 184 metastatic samples across 11 organs, including liver, lung, brain, and bone, and made the following observations. First, all PAM50 molecular intrinsic subtypes were represented across organs and within immunohistochemistry‐based groups. Second, HER2‐low disease was identified across all organ sites, including bone, and HER2 expression significantly correlated with ERBB2 expression. Third, the majority of expression variation was explained by intrinsic subtype and not organ of metastasis. Fourth, subtypes and individual subtype‐related genes/signatures were significantly associated with overall survival. Fifth, we identified 74 genes whose expression was organ‐specific and subtype‐independent. Finally, immune profiles were found more expressed in lung compared to brain or liver metastasis. Our results suggest that relevant tumor biology can be captured in metastatic tissues across a variety of organ sites; however, unique biological features according to organ site were also identified and future studies should explore their implications in diagnostic and therapeutic interventions.

Published
2022
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14. Remotely sensed between‐individual functional trait variation in a temperate forest

Author

Carla Guillén‐Escribà, Fabian D. Schneider, Bernhard Schmid, Andrew Tedder, Felix Morsdorf, Reinhard Furrer, Andreas Hueni, Pascal A. Niklaus, and Michael E. Schaepman

Subjects
airborne imaging spectroscopy, airborne laser scanning, functional traits, phylogenetic variation, remote sensing, within‐species variation, Ecology, QH540-549.5
Abstract

Abstract Trait‐based ecology holds the promise to explain how plant communities work, for example, how functional diversity may support community productivity. However, so far it has been difficult to combine field‐based approaches assessing traits at the level of plant individuals with limited spatial coverage and approaches using remote sensing (RS) with complete spatial coverage but assessing traits at the level of vegetation pixels rather than individuals. By delineating all individual‐tree crowns within a temperate forest site and then assigning RS‐derived trait measures to these trees, we combine the two approaches, allowing us to use general linear models to estimate the influence of taxonomic or environmental variation on between‐ and within‐species variation across contiguous space. We used airborne imaging spectroscopy and laser scanning to collect individual‐tree RS data from a mixed conifer‐angiosperm forest on a mountain slope extending over 5.5 ha and covering large environmental gradients in elevation as well as light and soil conditions. We derived three biochemical (leaf chlorophyll, carotenoids, and water content) and three architectural traits (plant area index, foliage‐height diversity, and canopy height), which had previously been used to characterize plant function, from the RS data. We then quantified the contributions of taxonomic and environmental variation and their interaction to trait variation and partitioned the remaining within‐species trait variation into smaller‐scale spatial and residual variation. We also investigated the correlation between functional trait and phylogenetic distances at the between‐species level. The forest consisted of 13 tree species of which eight occurred in sufficient abundance for quantitative analysis. On average, taxonomic variation between species accounted for more than 15% of trait variation in biochemical traits but only around 5% (still highly significant) in architectural traits. Biochemical trait distances among species also showed a stronger correlation with phylogenetic distances than did architectural trait distances. Light and soil conditions together with elevation explained slightly more variation than taxonomy across all traits, but in particular increased plant area index (light) and reduced canopy height (elevation). Except for foliage‐height diversity, all traits were affected by significant interactions between taxonomic and environmental variation, the different responses of the eight species to the within‐site environmental gradients potentially contributing to the coexistence of the eight abundant species. We conclude that with high‐resolution RS data it is possible to delineate individual‐tree crowns within a forest and thus assess functional traits derived from RS data at individual level. With this precondition fulfilled, it is then possible to apply tools commonly used in field‐based trait ecology to partition trait variation among individuals into taxonomic and potentially even genetic variation, environmental variation, and interactions between the two. The method proposed here presents a promising way of assessing individual‐based trait information with complete spatial coverage and thus allowing analysis of functional diversity at different scales. This information can help to better understand processes shaping community structure, productivity, and stability of forests.

Published
2021
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15. Digital nasoalveolar molding through presurgical orthopedics in newborns/infants with cleft lip and palate: A comprehensive review and case study

Author

Villarreal‐Martínez, Katia, primary, Fierro‐Serna, Victor, additional, Rosales‐Berber, Miguel A., additional, Alejandri‐Gamboa, Vanessa, additional, Torre‐Delgadillo, Gabriela, additional, Ruiz‐Rodríguez, Socorro, additional, Pozos‐Guillén, Amaury, additional, and Garrocho‐Rangel, Arturo, additional

Published
2024
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16. Polysensitization in the Spanish Contact Dermatitis Registry (REIDAC): A 2019–2022 prospective study with cluster and network analysis

Author

Pesqué, David, primary, Borrego, Leopoldo, additional, Zaragoza‐Ninet, Violeta, additional, Sanz‐Sánchez, Tatiana, additional, Miquel‐Miquel, Francisco Javier, additional, González‐Pérez, Ricardo, additional, Silvestre, Juan Francisco, additional, Córdoba‐Guijarro, Susana, additional, Carrascosa, José Manuel, additional, Gatica‐Ortega, María Elena, additional, Ruiz‐González, Inmaculada, additional, Mercader‐García, Pedro, additional, Tous‐Romero, Fátima, additional, Ortiz de Frutos, Francisco Javier, additional, Serra‐Baldrich, Esther, additional, Pastor‐Nieto, María Antonia, additional, Rodríguez‐Serna, Mercedes, additional, Sánchez‐Pérez, Javier, additional, Sánchez‐Gilo, Araceli, additional, Melé‐Ninot, Gemma, additional, Sánchez‐Pedreño Guillén, Paloma, additional, Pujol, Ramon Maria, additional, and Giménez‐Arnau, Ana María, additional

Published
2024
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18. Symptomatic gallstone disease: Recurrence patterns and risk factors for relapse after first admission, the RELAPSTONE study

Author

Velamazán, Raúl, primary, López‐Guillén, Pablo, additional, Martínez‐Domínguez, Samuel J., additional, Abad Baroja, Daniel, additional, Oyón, Daniel, additional, Arnau, Anna, additional, Ruiz‐Belmonte, Lara M., additional, Tejedor‐Tejada, Javier, additional, Zapater, Raul, additional, Martín‐Vicente, Noelia, additional, Fernández‐Esparcia, Pedro José, additional, Julián Gomara, Ana Belén, additional, Sastre Lozano, Violeta, additional, Manzanares García, Juan José, additional, Chivato Martín‐Falquina, Irene, additional, Andrés Pascual, Laura, additional, Torres Monclus, Nuria, additional, Zaragoza Velasco, Natividad, additional, Rojo, Eukene, additional, Lapeña‐Muñoz, Berta, additional, Flores, Virginia, additional, Díaz Gómez, Arantxa, additional, Cañamares‐Orbís, Pablo, additional, Vinzo Abizanda, Isabel, additional, Marcos Carrasco, Natalia, additional, Pardo Grau, Laura, additional, García‐Rayado, Guillermo, additional, Millastre Bocos, Judith, additional, Garcia Garcia de Paredes, Ana, additional, Vaamonde Lorenzo, María, additional, Izagirre Arostegi, Arantzazu, additional, Lozada‐Hernández, Edgard Efrén, additional, Velarde‐Ruiz Velasco, José Antonio, additional, and de‐Madaria, Enrique, additional

Published
2024
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19. Sensitisation to textile dyes in Spain: Epidemiological situation (2019–2022)

Author

Hernández Fernández, Carlos Pelayo, primary, Borrego, Leopoldo, additional, Giménez Arnau, Ana María, additional, Zaragoza Ninet, Violeta, additional, Sanz Sánchez, Tatiana, additional, Miquel Miquel, Francisco Javier, additional, González Pérez, Ricardo, additional, Silvestre Salvador, Juan Francisco, additional, Córdoba Guijarro, Susana, additional, Carrascosa Carrillo, José Manuel, additional, Gatica Ortega, María Elena, additional, Ruiz González, Inmaculada, additional, Mercader García, Pedro, additional, Tous Romero, Fátima, additional, Serra Baldrich, Esther, additional, Pastor‐Nieto, María Antonia, additional, Rodríguez Serna, Mercedes, additional, Sánchez Pérez, Javier, additional, Sánchez Gilo, Araceli, additional, Melé Ninot, Gemma, additional, Sánchez‐Pedreño Guillén, Paloma, additional, de Vega Martínez, Marina, additional, Descalzo, Miguel Ángel Gallego, additional, and Doval, Ignacio García, additional

Published
2024
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20. Efficacy and safety of cemiplimab in the treatment of advanced cutaneous squamous cell carcinoma: A multicentre real‐world retrospective study from Spain and systematic review of the published data

Author

Cañueto, J., primary, Muñoz‐Couselo, E., additional, Cardona‐Machado, C., additional, Becerril‐Andrés, S., additional, Martín‐Vallejo, J., additional, Serra‐Guillén, C., additional, Soria, A., additional, Serrano‐Domingo, J. J., additional, Ortiz‐Velez, C., additional, Lostes, J., additional, García‐Castaño, A., additional, Puig, S., additional, Fernández de Misa, R., additional, Medina, J., additional, Aguado, C., additional, Ayala de Miguel, P., additional, Navarro‐Nava, I., additional, Masferrer, E., additional, Delgado, M., additional, Bellido‐Hernández, L., additional, and Sanmartin, O., additional

Published
2024
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24. Mpox, herpes, and enteroviruses: Differential diagnosis

Author

Guillén‐Calvo, Laura, primary, Negredo, Anabel, additional, Sánchez‐Mora, Patricia, additional, Molero, Paqui, additional, Vázquez, Ana, additional, Cabrerizo, María, additional, Orviz, Eva, additional, Ledesma, Juan, additional, Estrada, Vicente, additional, Tarragó, David, additional, and Sánchez‐Seco, María Paz, additional

Published
2024
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25. Intraspecific genetic variation of a Fagus sylvatica population in a temperate forest derived from airborne imaging spectroscopy time series

Author

Ewa A. Czyż, Carla Guillén Escribà, Hendrik Wulf, Andrew Tedder, Meredith C. Schuman, Fabian D. Schneider, and Michael E. Schaepman

Subjects
imaging spectroscopy, intraspecific variation, partial least squares regression, population genetics, temperate forest, Ecology, QH540-549.5
Abstract

Abstract The growing pace of environmental change has increased the need for large‐scale monitoring of biodiversity. Declining intraspecific genetic variation is likely a critical factor in biodiversity loss, but is especially difficult to monitor: assessments of genetic variation are commonly based on measuring allele pools, which requires sampling of individuals and extensive sample processing, limiting spatial coverage. Alternatively, imaging spectroscopy data from remote platforms may hold the potential to reveal genetic structure of populations. In this study, we investigated how differences detected in an airborne imaging spectroscopy time series correspond to genetic variation within a population of Fagus sylvatica under natural conditions. We used multi‐annual APEX (Airborne Prism Experiment) imaging spectrometer data from a temperate forest located in the Swiss midlands (Laegern, 47°28'N, 8°21'E), along with microsatellite data from F. sylvatica individuals collected at the site. We identified variation in foliar reflectance independent of annual and seasonal changes which we hypothesize is more likely to correspond to stable genetic differences. We established a direct connection between the spectroscopy and genetics data by using partial least squares (PLS) regression to predict the probability of belonging to a genetic cluster from spectral data. We achieved the best genetic structure prediction by using derivatives of reflectance and a subset of wavebands rather than full‐analyzed spectra. Our model indicates that spectral regions related to leaf water content, phenols, pigments, and wax composition contribute most to the ability of this approach to predict genetic structure of F. sylvatica population in natural conditions. This study advances the use of airborne imaging spectroscopy to assess tree genetic diversity at canopy level under natural conditions, which could overcome current spatiotemporal limitations on monitoring, understanding, and preventing genetic biodiversity loss imposed by requirements for extensive in situ sampling.

Published
2020
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26. The oral KIF11 inhibitor 4SC‐205 exhibits antitumor activity and potentiates standard and targeted therapies in primary and metastatic neuroblastoma models

Author

Marc Masanas, Nuria Masiá, Leticia Suárez‐Cabrera, Mireia Olivan, Aroa Soriano, Blanca Majem, Laura Devis‐Jauregui, Rebeca Burgos‐Panadero, Carlos Jiménez, Pau Rodriguez‐Sodupe, Ariadna Boloix, Ignasi Toledano, Gabriela Guillén, Alexandra Navarro, David Llobet‐Navas, Alberto Villanueva, Josep Sánchez de Toledo, Josep Roma, Rosa Noguera, Lucas Moreno, Rolf Krauss, Soledad Gallego, Anna Santamaria, and Miguel F. Segura

Subjects
Medicine (General), R5-920
Published
2021
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27. PB2193: IS HYPERHYDRATION NECESSARY FOR HIGH DOSE MELPHALAN CONDITIONING REGIMEN IN AUTOLOGOUS HAEMATOPOIETIC STEM CELL TRANSPLANTATION?

Author

M. Mora Argumánez, A. Vázquez Ramo, B. Merchán Muñoz, R. Pérez Alonso, I. Nuevo López, Á. Gil Pérez, H. Guillén García, A. B. Santos Montero, J. Arbeteta Juanis, M. D. Morales Sanz, N. Golbano López, S. Herrero, and D. De Miguel Llorente

Subjects
Diseases of the blood and blood-forming organs, RC633-647.5
Published
2022
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28. Plasma biomarkers as prognostic markers in Alzheimer’s disease: Influence of age at onset

Author

Guillén, Núria, primary, Tort‐Merino, Adrià, additional, Falgàs Martínez, Neus, additional, Esteller, Diana, additional, Sarto, Jordi, additional, Castellví, Magdalena, additional, Juncà‐Parella, Jordi, additional, Borrego‐Écija, Sergi, additional, Bosch‐Capdevila, Beatriz, additional, González, Yolanda, additional, Fernandez‐Villullas, Guadalupe, additional, Ruiz‐García, Raquel, additional, Naranjo, Laura, additional, Antonell, Anna, additional, Balasa, Mircea, additional, Sanchez‐Valle, Raquel, additional, and Lladó, Albert, additional

Published
2023
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30. Exploring the relationship between MRI changes and cognitive/neuropsychiatric complaints in a cohort of long COVID‐19 patients: A cross‐sectional and longitudinal study

Author

Pérez‐Millan, Agnès, primary, Guillén, Núria, additional, Falgàs, Neus, additional, Botí, María Ángeles, additional, Tort‐Merino, Adrià, additional, Lledó‐Ibáñez, Gema María, additional, Ruiz‐García, Raquel, additional, Naranjo, Laura, additional, Rami, Lorena, additional, Balasa, Mircea, additional, Lladó, Albert, additional, Sala‐Llonch, Roser, additional, and Sanchez‐Valle, Raquel, additional

Published
2023
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31. Are noradrenergic and orexinergic systems contributing to sleep‐wake patterns in early and late‐onset Alzheimer’s Disease?

Author

Falgàs Martínez, Neus, primary, Muñoz‐Moreno, Emma, additional, Mayà, Gerard, additional, Muñoz‐Lopetegui, Amaia, additional, Marrero‐González, Paula, additional, Val‐Guardiola, Andrea, additional, Guillén, Núria, additional, Sarto, Jordi, additional, Bosch, Beatriz, additional, Balasa, Mircea, additional, Fernandez‐Villullas, Guadalupe, additional, Antonell, Anna, additional, Walsh, Christine M, additional, Ruoff, Leslie, additional, Joan, Santamaria, additional, Bargalló, Núria, additional, Lladó, Albert, additional, Morales‐Ruiz, Manuel, additional, Iranzo, Álex, additional, Grinberg, Lea T., additional, and Sanchez‐Valle, Raquel, additional

Published
2023
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32. Cognitive symptoms associated with COVID‐19: neuropsychological and biochemical characterization

Author

Guillén, Núria, primary, Pérez‐Millan, Agnès, additional, Martínez, Neus Falgàs, additional, Botí, María Ángeles, additional, Tort‐Merino, Adrià, additional, Lledó‐Ibáñez, Gema María, additional, Ruiz‐García, Raquel, additional, Naranjo, Laura, additional, Rami, Lorena, additional, Sala‐Llonch, Roser, additional, Balasa, Mircea, additional, Lladó, Albert, additional, and Sanchez‐Valle, Raquel, additional

Published
2023
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33. Plasma Neurofilament Light Chain predicts neuroimaging alterations and functional decline in frontotemporal dementia

Author

Borrego‐Écija, Sergi, primary, Juncà‐Parella, Jordi, additional, Ruiz‐García, Raquel, additional, Sarto, Jordi, additional, Martínez, Neus Falgàs, additional, Esteller, Diana, additional, Guillén, Núria, additional, Fernandez‐Villullas, Guadalupe, additional, González, Yolanda, additional, Pérez‐Millan, Agnès, additional, Tort‐Merino, Adrià, additional, Bosch, Beatriz, additional, Fort‐Aznar, Laura, additional, Antonell, Anna, additional, Naranjo, Laura, additional, Lladó, Albert, additional, Balasa, Mircea, additional, and Sanchez‐Valle, Raquel, additional

Published
2023
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34. Diagnostic performance RT‐QuIC based detection of alpha‐synuclein seeds in a clinical cohort with cognitive impairment

Author

Esteller, Diana, primary, Guillén, Núria, additional, Sarto, Jordi, additional, Ramos‐Campoy, Oscar, additional, Falgàs Martínez, Neus, additional, Molina, Laura, additional, Borrego‐Écija, Sergi, additional, Ruiz‐García, Raquel, additional, Naranjo, Laura, additional, Antonell, Anna, additional, Lladó, Albert, additional, Sanchez‐Valle, Raquel, additional, and Balasa, Mircea, additional

Published
2023
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35. Comparison of the diagnostic performance of blood‐based biomarkers using two distinct commercially available assays in a prospective memory clinic cohort

Author

Sarto, Jordi, primary, Guillén, Núria, additional, Esteller, Diana, additional, Martínez, Neus Falgàs, additional, Borrego‐Écija, Sergi, additional, Ramos‐Campoy, Oscar, additional, Contador, José, additional, Fernandez‐Villullas, Guadalupe, additional, González, Yolanda, additional, Tort‐Merino, Adrià, additional, Juncà‐Parella, Jordi, additional, Bosch‐Capdevila, Beatriz, additional, Antonell, Anna, additional, Molina, Laura, additional, Ruiz‐García, Raquel, additional, Naranjo, Laura, additional, Augé, Josep Maria, additional, Sanchez‐Valle, Raquel, additional, Balasa, Mircea, additional, and Lladó, Albert, additional

Published
2023
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36. Catalan Early Onset Dementia Network 2021 Report

Author

Guillén, Núria, primary, Balasa, Mircea, additional, Boada, Mercè, additional, Marquié, Marta, additional, Rosende‐Roca, Maitee, additional, Puig‐Pijoan, Albert, additional, Contador, José, additional, Fernández‐Lebrero, Aida, additional, Piñol‐Ripoll, Gerard, additional, Llena, Iolanda Riba, additional, Julián, Maria Ruiz, additional, Palasi, Antonio, additional, Maisterra, Olga, additional, Delgado, Pilar, additional, Alcolea, Daniel, additional, Fortea, Juan, additional, Lleó, Alberto, additional, López, Joan Bello, additional, González, Susana Fernández, additional, Rivera, Asunción Ávila, additional, Buongiorno, Mariateresa, additional, Bielecki, Jerzy Krupinski, additional, Castejón, Judith, additional, Vilas, Dolores, additional, Ispierto, Lourdes, additional, Rubio‐Roy, Marta, additional, Seckler, Ana Malagelada, additional, Vidal, María Teresa Abellán, additional, Romero, Teresa, additional, Casadevall, Teresa, additional, Lladó, Albert, additional, and Sanchez‐Valle, Raquel, additional

Published
2023
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37. Digital and plasma biomarkers for an early diagnosis of Mild Cognitive Impairment and prodromal Alzheimer’s disease

Author

Tort‐Merino, Adrià, primary, Sarto, Jordi, additional, Esteller, Diana, additional, Tarnanas, Ioannis, additional, Bügler, Maximilian, additional, Harms, Robbert, additional, Iulita, M. Florencia, additional, Santuccione, Antonella, additional, Ruiz‐García, Raquel, additional, Naranjo, Laura, additional, Martínez, Neus Falgàs, additional, Borrego‐Écija, Sergi, additional, Guillén, Núria, additional, Fernandez‐Villullas, Guadalupe, additional, Val‐Guardiola, Andrea, additional, Juncà‐Parella, Jordi, additional, Bosch, Beatriz, additional, Lladó, Albert, additional, Sanchez‐Valle, Raquel, additional, and Balasa, Mircea, additional

Published
2023
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38. Diagnosis in an early‐onset dementia clinic in the period 2016‐2021 and impact of COVID‐19 pandemic

Author

Guillén, Núria, primary, Contador, José, additional, Tort‐Merino, Adrià, additional, García, Andrea, additional, Martínez, Neus Falgàs, additional, Esteller, Diana, additional, Sarto, Jordi, additional, Castellví, Magdalena, additional, Vilas‐Riotorto, Vanessa G, additional, Juncà‐Parella, Jordi, additional, Borrego‐Écija, Sergi, additional, Bosch‐Capdevila, Beatriz, additional, González, Yolanda, additional, Fernandez‐Villullas, Guadalupe, additional, Antonell, Anna, additional, Balasa, Mircea, additional, Sanchez‐Valle, Raquel, additional, and Lladó, Albert, additional

Published
2023
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41. The academic point‐of‐care anti‐CD19 chimeric antigen receptor T‐cell product varnimcabtagene autoleucel (ARI‐0001 cells) shows efficacy and safety in the treatment of relapsed/refractory B‐cell non‐Hodgkin lymphoma

Author

Martínez‐Cibrián, Núria, primary, Ortiz‐Maldonado, Valentín, additional, Español‐Rego, Marta, additional, Blázquez, Andrea, additional, Cid, Joan, additional, Lozano, Miquel, additional, Magnano, Laura, additional, Giné, Eva, additional, Correa, Juan G., additional, Mozas, Pablo, additional, Rodríguez‐Lobato, Luis Gerardo, additional, Rivero, Andrea, additional, Montoro‐Lorite, Mercedes, additional, Ayora, Pilar, additional, Navarro, Sergio, additional, Alserawan, Leticia, additional, González‐Navarro, E. Azucena, additional, Castellà, Maria, additional, Sánchez‐Castañón, María, additional, Cabezón, Raquel, additional, Benítez‐Ribas, Daniel, additional, Setoaín, Xavier, additional, Rodríguez, Sonia, additional, Brillembourg, Helena, additional, Varea, Sara, additional, Olesti, Eulalia, additional, Guillén, Elena, additional, Sáez‐Peñataro, Joaquín, additional, de Larrea, Carlos Fernández, additional, López‐Guillermo, Armando, additional, Pascal, Mariona, additional, Urbano‐Ispizua, Álvaro, additional, Juan, Manel, additional, and Delgado, Julio, additional

Published
2023
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47. Green Alternatives in Treatment of Liver Diseases: the Challenges of Traditional Medicine and Green Nanomedicine

Author

Heya, Michel Stephane, primary, García‐Ponce, Romario, additional, Soto, Beatriz Amari Medina, additional, Verde‐Star, María Julia, additional, Soto‐Domínguez, Adolfo, additional, García‐Hernandez, David Gilberto, additional, Saucedo‐Cárdenas, Odila, additional, Hernández‐Salazar, Marcelo, additional, and Guillén‐Meléndez, Gloria Arely, additional

Published
2023
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48. Does the impact of COVID‐19 on patients with systemic sclerosis change over time?

Author

Deibel, Elisabeth, primary, Carreira, Patricia E., additional, Vonk, Madelon, additional, del Papa, Nicoletta, additional, Bečvář, Radim, additional, Guillén‐Del‐Castillo, Alfredo, additional, Campochiaro, Corrado, additional, Poormoghim, Hadi, additional, Liem, Sophie, additional, Lazzaroni, Maria‐Grazia, additional, Giollo, Alessandro, additional, Mekinian, Arsène, additional, de Vries‐Bouwstra, Jeska, additional, De Santis, Maria, additional, Balbir‐Gurman, Alexandra, additional, Mihai, Carina, additional, De Luca, Giacomo, additional, Moiseev, Sergey, additional, Zanatta, Elisabetta, additional, Foti, Rosario, additional, Rednic, Simona, additional, Denton, Christopher, additional, Cutolo, Maurizio, additional, Belloli, Laura, additional, Airo, Paolo, additional, Garzanova, Liudmila, additional, Moroncini, Gianluca, additional, İnanç, Murat, additional, Panopoulos, Stylianos, additional, Tandaipan, Jose‐Luis, additional, Chatelus, Emmanuel, additional, Rosato, Edoardo, additional, Kuwana, Masataka, additional, Yavuz, Sule, additional, Alegre‐Sancho, Juan J, additional, Smith, Vanessa, additional, Szűcs, Gabriella, additional, Henes, Joerg, additional, Rodríguez‐Pintó, Ignasi, additional, Atzeni, Fabiola, additional, Spierings, Julia, additional, Truchetet, Marie‐Elise, additional, Milchert, Marcin, additional, Brito de Araujo, Daniel, additional, Riemekasten, Gabriela, additional, Bernardino, Vera, additional, Martin, Thierry, additional, del Galdo, Francesco, additional, Vacca, Alessandra, additional, Mendoza, Fabian, additional, Midtvedt, Øyvind, additional, Murdaca, Giuseppe, additional, Santiago, Tânia, additional, Codullo, Veronica, additional, Cacciapaglia, Fabio, additional, Walker, Ulrich, additional, Brunborg, Cathrine, additional, Tirelli, Francesca, additional, Allanore, Yannick, additional, Furst, Daniel E., additional, Matucci, Marco, additional, Gabrielli, Armando, additional, Distler, Oliver, additional, and Hoffmann‐Vold, Anna‐Maria, additional

Published
2023
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