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Your search keyword '"Giunti, Massimo"' showing total 10 results
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10 results on '"Giunti, Massimo"'

1. Defining sepsis in small animals

Author

Cortellini, Stefano, primary, DeClue, Amy E., additional, Giunti, Massimo, additional, Goggs, Robert, additional, Hopper, Kate, additional, Menard, Julie M., additional, Rabelo, Rodrigo C., additional, Rozanski, Elizabeth A., additional, Sharp, Claire R., additional, Silverstein, Deborah C., additional, Sinnott‐Stutzman, Virginia, additional, and Stanzani, Giacomo, additional

Published
2024
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2. Evaluation of urinary neutrophil gelatinase‐associated lipocalin to detect renal tubular damage in dogs with stable myxomatous mitral valve disease

Author

Troia, Roberta, primary, Sabetti, Maria Chiara, additional, Crosara, Serena, additional, Quintavalla, Cecilia, additional, Romito, Giovanni, additional, Mazzoldi, Chiara, additional, Fidanzio, Francesca, additional, Cescatti, Maura, additional, Bertazzolo, Walter, additional, Giunti, Massimo, additional, and Dondi, Francesco, additional

Published
2022
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10. Plasma procalcitonin concentrations are increased in dogs with sepsis

Author

Matthew Milloway, Roberta Troia, Robert Goggs, Massimo Giunti, Goggs, Robert, Milloway, Matthew, Troia, Roberta, and Giunti, Massimo

Subjects
dogs, medicine.medical_specialty, 040301 veterinary sciences, Gastroenterology, Procalcitonin, sepsis, 0403 veterinary science, Sepsis, 03 medical and health sciences, 0302 clinical medicine, GDV, Internal medicine, parasitic diseases, Blood plasma, medicine, General Veterinary, business.industry, Stomach, Organ dysfunction, 030208 emergency & critical care medicine, 04 agricultural and veterinary sciences, Case Control Study, bacterial infections and mycoses, medicine.disease, Systemic inflammatory response syndrome, systemic inflammatory response syndrome, medicine.anatomical_structure, Gastric dilatation volvulus, dog, biomarker, Biomarker (medicine), sepsi, medicine.symptom, business, procalcitonin, hormones, hormone substitutes, and hormone antagonists
Abstract

Sepsis, the life-threatening organ dysfunction caused by a dysregulated host response to infection, is difficult to identify and to prognosticate for. In people with sepsis, procalcitonin (PCT) measurement aids diagnosis, enables therapeutic monitoring and improves prognostic accuracy. This study used a commercial canine PCT assay to measure plasma PCT concentrations in dogs with gastric dilatation volvulus (GDV) syndrome and in dogs with sepsis. It was hypothesised that dogs with GDV syndrome and with sepsis have greater plasma PCT concentrations than healthy dogs and that dogs with sepsis have greater PCT concentrations than dogs with GDV syndrome. Before analysing canine plasma samples, the ability of the assay to identify canine PCT, in addition to assay imprecision and the lower limit of detection were established. The assay had low imprecision with coefficients of variation ≤4.5 per cent. The lower limit of detection was 3.4 pg/ml. Plasma PCT concentrations were measured in 20 dogs with sepsis, in 32 dogs with GDV syndrome and in 52 healthy dogs. Median (IQR) PCT concentration in dogs with sepsis 78.7 pg/ml (39.1–164.7) was significantly greater than in healthy dogs 49.8 pg/ml (36.2–63.7) (P=0.019), but there were no significant differences between PCT concentrations in dogs with GDV syndrome and controls (P=0.072) or between dogs with sepsis and GDV syndrome (P=1.000). Dogs with sepsis have significantly increased plasma PCT concentrations compared with healthy dogs, although considerable overlap between these populations was identified. Future investigations should confirm this finding in other populations and evaluate the diagnostic and prognostic value of PCT in dogs with sepsis.

Published
2018

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