7 results on '"Giulia d’Amati"'
Search Results
2. Idiopathic Non Cirrhotic Portal Hypertension and Spleno-Portal Axis Abnormalities in Patients with Severe Primary Antibody Deficiencies
- Author
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Federica Pulvirenti, Ilaria Pentassuglio, Cinzia Milito, Michele Valente, Adriano De Santis, Valentina Conti, Giulia d’Amati, Oliviero Riggio, and Isabella Quinti
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Immunologic diseases. Allergy ,RC581-607 - Abstract
Background and Aim. Portal hypertension has been reported in association with acquired and primary immune deficiencies without a comprehensive description of associated spleno-portal axis abnormalities. Pathological mechanisms are poorly defined. Methods. Observational, single centre study with the aim of assessing the prevalence of spleno-portal axis abnormalities in an unselected cohort of 123 patients with primary antibody deficiencies and without known causes of liver diseases regularly followed up for a mean time of 18 ± 14 years. A cumulative period of 1867 patients-year was analysed. Clinical and immunological data, abdominal ultrasounds, CT scans, and endoscopy features were included in the analysis. Results. Twenty-five percent of patients with primary antibody deficiencies had signs of portal vein enlargement but only 4% of them had portal hypertension, with portal systemic collaterals. Liver biopsies showed liver sinusoids congestive dilatation, endothelization, and micronodularity fulfilling the criteria for noncirrhotic portal hypertension. Patients with portal vein enlargement had severe clinical and immunological phenotypes. Conclusions. In primary antibody deficient patients, infections, inflammations, splenomegaly, increased blood venous flow, and lymphocyte abnormalities contribute to establishment of liver damage possibly leading to noncirrhotic portal hypertension. Patients with primary antibody deficiency should be considered a good model to give insight into the pathological mechanisms underlying noncirrhotic portal hypertension.
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- 2014
- Full Text
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3. Plasmatic and myocardial microRNA profiles in patients with Hypertrophic Cardiomyopathy
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Davide Lazzeroni, Michela Riba, Maria Lombardi, Giulia d'Amati, Chiara Foglieni, Dejan Lazarevic, O Rimoldi, Iacopo Olivotto, Francesco De Cobelli, Paolo G. Camici, Gloria Bertoli, Giulia Benedetti, Lombardi, Maria, Lazzeroni, Davide, Benedetti, Giulia, Bertoli, Gloria, Lazarevic, Dejan, Riba, Michela, De Cobelli, Francesco, Rimoldi, Ornella, D'Amati, Giulia, Olivotto, Iacopo, Foglieni, Chiara, and Camici, Paolo
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Medicine (General) ,medicine.medical_specialty ,Hypertrophic Cardiomyopathy ,Medicine (miscellaneous) ,Letter to Editor ,R5-920 ,microRNAs ,hypertrophyc cardiomyopathy ,plasma ,myocardium ,Internal medicine ,microRNA ,medicine ,Humans ,In patient ,business.industry ,PTEN Phosphohydrolase ,Hypertrophic cardiomyopathy ,High-Throughput Nucleotide Sequencing ,Cardiomyopathy, Hypertrophic ,medicine.disease ,Case-Control Studies ,Cardiology ,Molecular Medicine ,business ,Biomarkers - Published
- 2021
4. Diagnostic Value of Endomyocardial Biopsy Guided by Electroanatomic Voltage Mapping in Arrhythmogenic Right Ventricular Cardiomyopathy/Dysplasia
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Gemma Pelargonio, Elisabetta Zachara, Piergiuseppe De Girolamo, Giuseppe Messina, Andrea Avella, Pasquale Baratta, Paolo Zecchi, Antonio Dello Russo, Paola Francesca Silenzi, Federica Re, Claudio Tondo, Augusto Pappalardo, Francesco Laurenzi, and Giulia d'Amati
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medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,Cardiomyopathy ,right ventricle ,arrhythmia ,medicine.disease ,Right ventricular cardiomyopathy ,Group B ,medicine.anatomical_structure ,Dysplasia ,Ventricle ,Physiology (medical) ,Internal medicine ,Biopsy ,medicine ,Cardiology ,biopsy ,cardiomyopathy ,mapping ,Sampling (medicine) ,Sinus rhythm ,Cardiology and Cardiovascular Medicine ,business - Abstract
UNLABELLED Voltage Mapping-Guided Biopsy in ARVC/D. INTRODUCTION To improve the endomyocardial biopsy (EMB) diagnostic sensitivity for arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D), we hypothesized a biopsy sampling focused on selected right ventricle (RV) low-voltage areas identified by electroanatomic voltage mapping. METHODS AND RESULTS The study population (22 patients, 10 men; mean age 34 +/- 10 years) included 11 patients with overt ARVC/D (group A) and 11 patients with suspected ARVC/D (group B), according to both arrhythmic profile and standardized noninvasive diagnostic criteria. In all 22 patients, an RV bipolar voltage mapping was performed with CARTO system sampling multiple endocardial sites (262 +/- 61), during sinus rhythm, with a 0.5-1.5 mV color range setting of voltage display. All 11 (100%) group A patients and 8 of the 11 (73%) group B patients (P = nonsignificant [NS]) presented RV low-voltage areas (
- Published
- 2008
5. Heat Shock Proteins and Autoimmunity in Patients with Carotid Atherosclerosis
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Elisabetta Profumo, Flora Ippoliti, Rita Businaro, Brigitta Buttari, Giulia d'Amati, Rachele Riganò, Linda Petrone, Raffaele Capoano, Bruno Salvati, Angela Tagliani, and Lorenzo Fumagalli
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Carotid Artery Diseases ,Arteriosclerosis ,General Neuroscience ,Autoimmunity ,Biology ,medicine.disease_cause ,Autoantigens ,Peripheral blood mononuclear cell ,General Biochemistry, Genetics and Molecular Biology ,In vitro ,Immune system ,History and Philosophy of Science ,Downregulation and upregulation ,Heat shock protein ,Immunology ,medicine ,biology.protein ,Animals ,Humans ,antibodies ,autoantigens ,carotid atherosclerosis ,endothelial cells ,heat shock proteins ,immune response ,oxidative stress ,t lymphocytes ,Antibody ,Heat-Shock Proteins ,Oxidative stress - Abstract
Studies aimed at elucidating the pathogenetic mechanisms underlying the initiation and progression of human atherosclerosis have emphasized the central role of inflammatory and immune cells. Atherosclerotic plaques are infiltrated by activated macrophages, T and B lymphocytes, plasma cells, and mast cells, releasing inflammatory molecules, which amplify the severity of the disease. Endothelial cells subjected to various stress conditions express increased amounts of heat shock proteins (HSPs), some of the most successfully conserved proteins throughout evolution. Many experimental observations reviewed in this article draw attention to several HSPs targeted by a specific cellular and humoral immune response in patients with atherosclerotic disease. The review also reports preliminary data obtained by our group on the possible role of HSP90 as a candidate autoantigen in carotid atherosclerosis. Our study deals with the presence of specific antibodies and T cells directed against HSP90 in patients with carotid atherosclerotic plaques. In 60% of these subjects' sera but in none of the sera from healthy controls immunoblotting (IB) detected the presence of specific antibodies. Moreover, 20% of peripheral blood mononuclear cells (PBMC) samples from patients but none from healthy subjects proliferated in response to human purified HSP90. In vitro experiments showed an upregulation of HSP90 expression in endothelial cells exposed to oxidative stress by treatment with H(2)O(2) and greater release of soluble HSP90 in culture supernatants from H(2)O(2)-treated cells than from untreated cells.
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- 2007
6. Pathological Findings of HIV‐Associated Cardiovascular Disease
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Cira Di Gioia, Giulia d'Amati, and Pietro Gallo
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medicine.medical_specialty ,Cardiovascular pathology ,Myocardial Ischemia ,Human immunodeficiency virus (HIV) ,Cardiomyopathy ,Improved survival ,HIV Infections ,hiv ,Disease ,medicine.disease_cause ,General Biochemistry, Genetics and Molecular Biology ,Heart Neoplasms ,History and Philosophy of Science ,Acquired immunodeficiency syndrome (AIDS) ,Internal medicine ,cardiac pathology ,myocardium ,medicine ,Humans ,Endocarditis ,Pathological ,business.industry ,General Neuroscience ,virus diseases ,aids ,cardiomyopathy ,endocarditis ,medicine.disease ,Myocarditis ,Cardiovascular Diseases ,Cardiology ,Cardiomyopathies ,business ,Pericardium - Abstract
More effective therapies have improved survival times of HIV+ patients, resulting in a higher prevalence of long-term complications of the disease. This review focuses on HIV-associated cardiovascular pathology, correlating the morphologic findings to clinical syndromes of HIV disease/AIDS.
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- 2001
7. Endomyocardial Biopsy Guided by Electroanatomic Voltage Mapping in Arrhythmogenic Right Ventricular Cardiomyopathy: A Case Report
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Augusto Pappalardo, Claudio Tondo, Paolo Zecchi, Elisabetta Zachara, Giulia d'Amati, Federica Re, Andrea Avella, Antonio Dello Russo, Massimiliano Mancini, and Francesco Laurenzi
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Adult ,Male ,medicine.medical_specialty ,Electroanatomic mapping ,Substrate mapping ,diagnosis ,Ventricular Dysfunction, Right ,substrate mapping ,Perforation (oil well) ,Cardiomyopathy ,right ventricle ,arrhythmia ,Right ventricular cardiomyopathy ,electroanatomic mapping ,Endomyocardial biopsy ,Physiology (medical) ,Internal medicine ,Humans ,Medicine ,Interventricular septum ,business.industry ,Myocardium ,Biopsy, Needle ,Body Surface Potential Mapping ,medicine.disease ,medicine.anatomical_structure ,cardiomyopathy ,endomyocardial biopsy ,Ventricle ,Tachycardia, Ventricular ,Cardiology ,Radiology ,Cardiomyopathies ,Cardiology and Cardiovascular Medicine ,business - Abstract
A positive endomyocardial biopsy (EMB) is a major diagnostic criterion for arrhythmogenic right ventricular cardiomyopathy (ARVC). Nevertheless, its sensitivity is low due to the focal nature of the disease. Moreover, myocardial samples are usually taken from the uncommonly involved interventricular septum to minimize the risk of perforation. In this report, we describe a novel bioptical approach for ARVC diagnosis guided by the identification of right ventricle (RV) affected regions by means of electroanatomical voltage mapping.
- Published
- 2007
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