1. Cerebrospinal fluid and serum interleukins 6 and 8 during the acute and recovery phase in COVID‐19 neuropathy patients
- Author
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Martina Fabris, Laura Cecotti, Paolo Manganotti, Arianna Sartori, Laura D Acunto, Valentina Pesavento, Giulia Bellavita, Giovanni Furlanis, Alex Buoite Stella, Lucia Bonzi, Valentina Tommasini, Manganotti, P., Bellavita, G., Tommasini, V., D'Acunto, L., Fabris, M., Cecotti, L., Furlanis, G., Sartori, A., Bonzi, L., Buoite Stella, A., and Pesavento, V.
- Subjects
Male ,Neural Conduction ,Action Potentials ,Gastroenterology ,Lopinavir ,0302 clinical medicine ,Cerebrospinal fluid ,Electroneuronography ,030212 general & internal medicine ,Research Articles ,Darunavir ,media_common ,Guillain-Barre syndrome ,interleukin ,polyradiculonevritis ,Convalescence ,Immunoglobulins, Intravenous ,Prognosis ,Anti-Bacterial Agents ,Compound muscle action potential ,Drug Combinations ,Infectious Diseases ,Acute Disease ,030211 gastroenterology & hepatology ,medicine.symptom ,Respiratory Insufficiency ,COVID-19 ,IL-6 ,IL-8 ,interleukins ,Hydroxychloroquine ,Research Article ,medicine.drug ,medicine.medical_specialty ,media_common.quotation_subject ,Inflammation ,Guillain-Barre Syndrome ,Clinical neurophysiology ,03 medical and health sciences ,COVID‐19 ,Virology ,Internal medicine ,Peripheral Nervous System ,medicine ,Humans ,Aged ,Ritonavir ,Interleukin-6 ,SARS-CoV-2 ,business.industry ,Interleukin-8 ,IL‐6 ,IL‐8 ,medicine.disease ,COVID-19 Drug Treatment ,business ,Biomarkers - Abstract
This case series describes three patients affected by severe acute respiratory syndrome coronavirus 2, who developed polyradiculoneuritis as a probable neurological complication of coronavirus disease 2019 (COVID‐19). A diagnosis of Guillain Barré syndrome was made on the basis of clinical symptoms, cerebrospinal fluid analysis, and electroneurography. In all of them, the therapeutic approach included the administration of intravenous immunoglobulin (0.4 gr/kg for 5 days), which resulted in the improvement of neurological symptoms. Clinical neurophysiology revealed the presence of conduction block, absence of F waves, and in two cases, a significant decrease in amplitude of compound motor action potential cMAP. Due to the potential role of inflammation on symptoms development and prognosis, interleukin‐6 (IL‐6) and IL−8 levels were measured in serum and cerebrospinal fluid during the acute phase, while only serum was tested after recovery. Both IL‐6 and IL‐8 were found increased during the acute phase, both in the serum and cerebrospinal fluid, whereas 4 months after admission (at complete recovery), only IL‐8 remained elevated in the serum. These results confirm the inflammatory response that might be linked to peripheral nervous system complications and encourage the use of IL‐6 and IL‐8 as prognostic biomarkers in COVID‐19.
- Published
- 2021