Search

Your search keyword '"Girerd B"' showing total 5 results
Start Over Author "Girerd B" Publisher wiley
5 results on '"Girerd B"'

2. Association of a KCNA5 Gene Polymorphism With Systemic Sclerosis-Associated Pulmonary Arterial Hypertension in the European Caucasian Population

Author

Wipff, J., Dieude, P., Guedj, M., Ruiz, B., Riemekasten, G., Cracowski, J. L., Matucci-Cerinic, M., Melchers, I., Humbert, M., Hachulla, E., Airo, P., Diot, E., Hunzelmann, N., Caramaschi, P., Sibilia, J., Valentini, G., Tiev, K., Girerd, B., Mouthon, L., Riccieri, V., Carpentier, P. H., Distler, J., Amoura, Z., Tarner, I., Degano, B., Avouac, J., Meyer, O., Kahan, A., Boileau, C., Allanore, Y., Wipff, J., Dieude, P., Guedj, M., Ruiz, B., Riemekasten, G., Cracowski, J. L., Matucci-Cerinic, M., Melchers, I., Humbert, M., Hachulla, E., Airo, P., Diot, E., Hunzelmann, N., Caramaschi, P., Sibilia, J., Valentini, G., Tiev, K., Girerd, B., Mouthon, L., Riccieri, V., Carpentier, P. H., Distler, J., Amoura, Z., Tarner, I., Degano, B., Avouac, J., Meyer, O., Kahan, A., Boileau, C., and Allanore, Y.

Abstract

Objective. Pulmonary arterial hypertension (PAH) has emerged as a leading cause of death in systemic sclerosis (SSc). The genetic basis of PAH has been unraveled in recent years, with a major role played by transforming growth factor beta receptors; however, some other candidate genes have also been advocated, including potassium voltage-gated channel, shaker-related subfamily, member 5 (KCNA5). We undertook this study to determine whether KCNA5 polymorphisms confer susceptibility to SSc and its vascular phenotype, including PAH. Methods. Four KCNA5 single-nucleotide polymorphisms (SNPs), rs10744676, rs1860420, rs3741930, and rs2284136, were genotyped in a discovery set of 638 SSc patients and 469 controls. In addition, rs10744676 was genotyped in an independent replication sample (938 SSc patients and 564 controls) and in a cohort of 168 patients with different PAH subtypes. Results. The KCNA5 rs10744676 variant was found to be associated with SSc in the discovery sample, with an odds ratio (OR) of 0.62 (95% confidence interval [95% CI] 0.48-0.79, adjusted P = 0.0003) in comparison with controls (C allele frequency 11.4% versus 17.2%). When subphenotypes were investigated, an association was found solely for PAH associated with SSc (OR 0.31 [95% CI 0.13-0.71], adjusted P = 0.04). The other KCNA5 SNPs tested were not associated with any SSc subset. The above association with PAH associated with SSc was replicated in the second set. In the combined population, rs10744676 was strongly associated with PAH associated with SSc in comparison with controls (OR 0.36 [95% CI 0.21-0.63], P = 0.0002). In the independent cohort of patients with PAH, after investigating PAH subtypes, only rs10744676 showed an association with PAH associated with SSc. Conclusion. Our results provide the first evidence for an association between the KCNA5 rs10744676 variant and PAH associated with SSc.

Published
2010

4. Association of a KCNA5 gene polymorphism with systemic sclerosis–associated pulmonary arterial hypertension in the European Caucasian population

Author

Wipff, J., primary, Dieudé, P., additional, Guedj, M., additional, Ruiz, B., additional, Riemekasten, G., additional, Cracowski, J. L., additional, Matucci‐Cerinic, M., additional, Melchers, I., additional, Humbert, M., additional, Hachulla, E., additional, Airo, P., additional, Diot, E., additional, Hunzelmann, N., additional, Caramaschi, P., additional, Sibilia, J., additional, Valentini, G., additional, Tiev, K., additional, Girerd, B., additional, Mouthon, L., additional, Riccieri, V., additional, Carpentier, P. H., additional, Distler, J., additional, Amoura, Z., additional, Tarner, I., additional, Degano, B., additional, Avouac, J., additional, Meyer, O., additional, Kahan, A., additional, Boileau, C., additional, and Allanore, Y., additional

Published
2010
Full Text
View/download PDF

5. Small platelet microparticle levels are increased in pulmonary arterial hypertension.

Author

Nadaud S, Poirier O, Girerd B, Blanc C, Montani D, Eyries M, Imbert-Bismut F, Pacheco A, Vigne J, Tregouet DA, Humbert M, and Soubrier F

Subjects
Adult, Aged, Case-Control Studies, Cell-Derived Microparticles classification, Female, Flow Cytometry, Genotype, Humans, Hypertension, Pulmonary classification, Hypertension, Pulmonary genetics, Linear Models, Male, Middle Aged, Blood Platelets cytology, Bone Morphogenetic Protein Receptors, Type II analysis, Cell-Derived Microparticles metabolism, Endothelial Cells cytology, Hypertension, Pulmonary blood
Abstract

Background: The various aetiologies and risk factors for pulmonary arterial hypertension (PAH) lead to close phenotypes with small differences. Plasma microparticles have been shown to be increased in vascular pathologies including PAH. The aim of this study was to determine whether the levels of endothelial and platelet-derived microparticles could vary between different forms of PAH: idiopathic PAH (iPAH), heritable PAH associated with BMPR2 (Bone morphogenetic protein receptor, type II) mutation (hPAH) and PAH associated with connective tissue diseases (aPAH)., Materials and Methods: Microparticles were analysed using flow cytometry in plasma from controls and iPAH, hPAH and aPAH patients. Platelet-derived MP (PMP) were defined as CD31(+)/CD41(+) and endothelial-derived MP (EMP) as CD31(+)/CD41(-). Two populations of PMP were isolated according to their size, defining small PMP (0·3-0·5 μm) and large PMP (0·5-0·9 μm). BMPR2 genotype, clinical and biologic parameters were recorded., Results: EMP and small PMP levels in iPAH, hPAH and aPAH were similar and were significantly increased as compared with controls. No differences in large PMP levels were observed. After adjusting for age, sex, proBNP and CRP, EMP and small PMP levels did not correlate with clinical parameters., Conclusions: iPAH, hPAH and aPAH were characterized by increased levels of EMP and of small PMP, a new class of PMP which seems to be differentially produced than large PMP., (© 2012 The Authors. European Journal of Clinical Investigation © 2012 Stichting European Society for Clinical Investigation Journal Foundation.)

Published
2013
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results