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2. Plasma kinetics and urinary excretion of primaquine in man

Author

DA Evans, J Greaves, Danai Bunnag, K. A. Fletcher, Tranakchit Harinasuta, and Gilles Hm

Subjects
medicine.medical_specialty, Primaquine, Urine, Glycogen Storage Disease Type I, Pharmacology, Thais, Multiple dose, White People, Intestinal absorption, Urinary excretion, Asian People, Internal medicine, parasitic diseases, medicine, Humans, Pharmacology (medical), biology, biology.organism_classification, Kinetics, stomatognathic diseases, Plasma kinetics, Endocrinology, Intestinal Absorption, geographic locations, Research Article, medicine.drug
Abstract

1 The kinetics of primaquine have been studied in twenty volunteers after single and multiple dose regimes. 2 The kinetic parameters were similar in glucose-6-phosphate dehydrogenase (G6PD) normal Thais, G6PD deficient Thais and in Caucasians. 3 The Caucasian subjects showed about 1% of the dose was excreted in the urine. 4 The kinetic parameters obtained from multiple dose studies in Thais were very similar to those obtained from single dose studies in Thais.

Published
1980
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6. Diethylcarbamazine disposition in patients with onchocerciasis.

Author

Edwards G, Awadzi K, Breckenridge AM, Gilles HM, Orme ML, and Ward SA

Subjects
Adult, Biotransformation, Diethylcarbamazine therapeutic use, Humans, Kidney metabolism, Kinetics, Male, Middle Aged, Onchocerciasis drug therapy, Diethylcarbamazine metabolism, Onchocerciasis metabolism
Abstract

Diethylcarbamazine (DEC), 0.5 mg/kg, was taken orally by six patients being treated for onchocerciasis. Blood samples were taken at timed intervals for 48 hr and urine and feces collected for 4 days. Plasma and urinary concentrations of DEC and DEC N-oxide were measured by gas-liquid chromatography. DEC appeared to be rapidly absorbed, with a peak plasma concentration of 150 to 250 ng/ml reached in 2 to 3 hr. There was a secondary rise in plasma DEC concentration at 5 to 6 hr in all patients. In contrast to the way the drug is eliminated in rats, in man it was by both renal and extrarenal routes, with small amounts (+/- 10%) being excreted as an N-oxide metabolite. DEC kinetics were also investigated in five normal subjects and the result were much the same. Clinical implications are discussed.

Published
1981
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