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Your search keyword '"Gerevich, Zoltan"' showing total 12 results
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12 results on '"Gerevich, Zoltan"'

3. Adenosine A1receptor-mediated suppression of carbamazepine-resistant seizure-like events in human neocortical slices

Author

Klaft, Zin-Juan, primary, Hollnagel, Jan-Oliver, additional, Salar, Seda, additional, Calişkan, Gürsel, additional, Schulz, Steffen B., additional, Schneider, Ulf C., additional, Horn, Peter, additional, Koch, Arend, additional, Holtkamp, Martin, additional, Gabriel, Siegrun, additional, Gerevich, Zoltan, additional, and Heinemann, Uwe, additional

Published
2016
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12. Extracellular ATP inhibits excitatory synaptic input on parvalbumin positive interneurons and attenuates gamma oscillations via P2X4 receptors.

Author

Wildner F, Neuhäusel TS, Klemz A, Kovács R, Ulmann L, Geiger JRP, and Gerevich Z

Subjects
Animals, Male, Mice, Rats, Excitatory Postsynaptic Potentials drug effects, Mice, Inbred C57BL, Gamma Rhythm drug effects, Gamma Rhythm physiology, Rats, Wistar, Hippocampus drug effects, Hippocampus metabolism, Hippocampus physiology, Interneurons drug effects, Interneurons physiology, Interneurons metabolism, Adenosine Triphosphate analogs & derivatives, Adenosine Triphosphate metabolism, Adenosine Triphosphate pharmacology, Parvalbumins metabolism, Mice, Knockout, Receptors, Purinergic P2X4 metabolism
Abstract

Background and Purpose: P2X4 receptors (P2X4R) are ligand gated cation channels that are activated by extracellular ATP released by neurons and glia. The receptors are widely expressed in the brain and have fractional calcium currents comparable with NMDA receptors. Although P2X4Rs have been reported to modulate synaptic transmission and plasticity, their involvement in shaping neuronal network activity remains to be elucidated., Experimental Approach: We investigated the effects of P2X receptors at network and synaptic level using local field potential electrophysiology, whole cell patch clamp recordings and calcium imaging in fast spiking parvalbumin positive interneurons (PVINs) in rat and mouse hippocampal slices. The stable ATP analogue ATPγS, selective antagonists and P2X4R knockout mice were used., Key Results: The P2XR agonist ATPγS reversibly decreased the power of gamma oscillations. This inhibition could be antagonized by the selective P2X4R antagonist PSB-12062 and was not observed in P2X4 -/- mice. The phasic excitatory inputs of CA3 PVINs were one of the main regulators of the gamma power. Associational fibre compound excitatory postsynaptic currents (cEPSCs) in CA3 PVINs were inhibited by P2X4R activation. This effect was reversible, dependent on intracellular calcium and dynamin-dependent internalization of AMPA receptors., Conclusions and Implications: The results indicate that P2X4Rs are an important source of dendritic calcium in CA3 PVINs, thereby regulating excitatory synaptic inputs onto the cells and presumably the state of gamma oscillations in the hippocampus. P2X4Rs represent an effective target to modulate hippocampal network activity in pathophysiological conditions such as Alzheimer's disease and schizophrenia., (© 2023 The Authors. British Journal of Pharmacology published by John Wiley & Sons Ltd on behalf of British Pharmacological Society.)

Published
2024
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