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36 results on '"Gee, Antony D"'

2. Open letter to journal editors on : International consensus radiochemistry nomenclature guidelines

Author

Coenen, Heinz H., Gee, Antony D., Adam, Michael, Antoni, Gunnar, Cutler, Cathy S., Fujibayashi, Yasuhisa, Jeong, Jae Min, Mach, Robert H., Mindt, Thomas L., Pike, Victor W., Windhorst, Albert D., Coenen, Heinz H., Gee, Antony D., Adam, Michael, Antoni, Gunnar, Cutler, Cathy S., Fujibayashi, Yasuhisa, Jeong, Jae Min, Mach, Robert H., Mindt, Thomas L., Pike, Victor W., and Windhorst, Albert D.

Published
2018
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11. Abstracts of the 21st International Isotope Society (UK group) symposium: synthesis and applications of labelled compounds 2012

Author

Årstad, Erik, primary, Badar, Adam, additional, Baxter, Andrew, additional, Bower, John F., additional, Cable, Karl M., additional, Carroll, Michael A., additional, Chan, Melanie Y. T., additional, Charlton, Michael, additional, Christlieb, Martin, additional, Cornelissen, Bart, additional, Cox, Liam R., additional, Davis, Ben, additional, Dilworth, Jonathan R., additional, El-Emir, Ethaar, additional, Ellames, George J., additional, Galante, Eva, additional, Geach, Neil, additional, Gee, Antony D., additional, Gouverneur, Véronique, additional, Gregson, Thomas J., additional, Hendry, David, additional, Hueting, Rebekka, additional, Hussien, Kamila, additional, Ilyas, Tenzeela, additional, Jenkins, Daniel D., additional, Kersemans, Veerle, additional, Knagg, Eric, additional, Koepp, Matthias, additional, Kohler, Andrew D., additional, Krauser, Joel A., additional, Launay, Guillaume G., additional, Lockley, William J. S., additional, Lythgoe, Mark F., additional, Manthorpe, Daniel P., additional, McEwen, Andrew, additional, Muschel, Ruth J., additional, Oldfield, Mark F., additional, Passchier, Jan, additional, Pedley, R. Barbara, additional, Rajkumar, Vineeth, additional, Reed, Christopher D., additional, Robson, Mathew, additional, Roe, Stephen J., additional, Ryan, Jim J., additional, Sander, Kerstin, additional, Shipley, Nick, additional, Smart, Sean C., additional, Smith, Neil, additional, Spurr, Daniel W., additional, Taylor, Keith R., additional, Tredwell, Matthew, additional, Whitehead, David M., additional, Woolley, Geoffrey, additional, and Yan, Ran, additional

Published
2013
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14. ChemInform Abstract: Palladium-Catalyzed Allylic Fluorination.

Author

Hollingworth, Charlotte, primary, Hazari, Amaruka, additional, Hopkinson, Matthew N., additional, Tredwell, Matthew, additional, Benedetto, Elena, additional, Huiban, Mickael, additional, Gee, Antony D., additional, Brown, John M., additional, and Gouverneur, Veronique, additional

Published
2011
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17. Palladium‐Catalyzed Allylic Fluorination

Author

Hollingworth, Charlotte, primary, Hazari, Amaruka, additional, Hopkinson, Matthew N., additional, Tredwell, Matthew, additional, Benedetto, Elena, additional, Huiban, Mickael, additional, Gee, Antony D., additional, Brown, John M., additional, and Gouverneur, Véronique, additional

Published
2011
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29. In vivo and in vitro measurement of brain phosphodiesterase 4 in rats after antidepressant administration

Author

Fujita, Masahiro, primary, Imaizumi, Masao, additional, D'Sa, Carrol, additional, Zoghbi, Sami S., additional, Crescenzo, Matthew S., additional, Hong, Jinsoo, additional, Musachio, John L., additional, Gee, Antony D., additional, Seidel, Jurgen, additional, Green, Michael V., additional, Pike, Victor W., additional, Duman, Ronald S., additional, and Innis, Robert B., additional

Published
2006
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30. Behaviour of [11C]R(?)- and [11C]S(+)-rolipram in vitro and in vivo, and their use as PET radiotracers for the quantificative assay of PDE4

Author

Parker, Christine A., primary, Matthews, Julian C., additional, Gunn, Roger N., additional, Martarello, Laurent, additional, Cunningham, Vincent J., additional, Dommett, David, additional, Knibb, Stephen T., additional, Bender, Dirk, additional, Jakobsen, Steen, additional, Brown, John, additional, and Gee, Antony D., additional

Published
2005
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33. In-loop flow [ 11 C]CO 2 fixation and radiosynthesis of N,N'-[ 11 C]dibenzylurea.

Author

Downey J, Bongarzone S, Hader S, and Gee AD

Subjects
Benzyl Compounds chemistry, Cyclotrons, Fluorocarbons chemistry, Proof of Concept Study, Carbon Dioxide chemistry, Carbon Radioisotopes chemistry, Radiopharmaceuticals chemical synthesis, Urea analogs & derivatives
Abstract

Cyclotron-produced carbon-11 is a highly valuable radionuclide for the production of positron emission tomography (PET) radiotracers. It is typically produced as relatively unreactive carbon-11 carbon dioxide ([ 11 C]CO 2 ), which is most commonly converted into a more reactive precursor for synthesis of PET radiotracers. The development of [ 11 C]CO 2 fixation methods has more recently enabled the direct radiolabelling of a diverse array of structures directly from [ 11 C]CO 2 , and the advantages afforded by the use of a loop-based system used in 11 C-methylation and 11 C-carboxylation reactions inspired us to apply the [ 11 C]CO 2 fixation "in-loop." In this work, we developed and investigated a new ethylene tetrafluoroethylene (ETFE) loop-based [ 11 C]CO 2 fixation method, enabling the fast and efficient, direct-from-cyclotron, in-loop trapping of [ 11 C]CO 2 using mixed DBU/amine solutions. An optimised protocol was integrated into a proof-of-concept in-loop flow radiosynthesis of N,N'-[ 11 C]dibenzylurea. This reaction exhibited an average 78% trapping efficiency and a crude radiochemical purity of 83% (determined by radio-HPLC), giving an overall nonisolated radiochemical yield of 72% (decay-corrected) within just 3 minutes from end of bombardment. This proof-of-concept reaction has demonstrated that efficient [ 11 C]CO 2 fixation can be achieved in a low-volume (150 μL) ETFE loop and that this can be easily integrated into a rapid in-loop flow radiosynthesis of carbon-11-labelled products. This new in-loop methodology will allow fast radiolabelling reactions to be performed using cheap/disposable ETFE tubing setup (ideal for good manufacturing practice production) thereby contributing to the widespread usage of [ 11 C]CO 2 trapping/fixation reactions for the production of PET radiotracers., (© 2017 The Authors. Journal of Labelled Compounds and Radiopharmaceuticals Published by John Wiley & Sons, Ltd.)

Published
2018
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34. Recent progress in [ 11 C]carbon dioxide ([ 11 C]CO 2 ) and [ 11 C]carbon monoxide ([ 11 C]CO) chemistry.

Author

Taddei C and Gee AD

Subjects
Positron-Emission Tomography methods, Carbon Dioxide chemistry, Carbon Monoxide chemistry, Carbon Radioisotopes chemistry, Radiopharmaceuticals chemical synthesis
Abstract

[ 11 C]Carbon dioxide ([ 11 C]CO 2 ) and [ 11 C]carbon monoxide ([ 11 C]CO) are 2 attractive precursors for labelling the carbonyl position (C═O) in a vast range of functionalised molecules (eg, ureas, amides, and carboxylic acids). The development of radiosynthetic methods to produce functionalised 11 C-labelled compounds is required to enhance the radiotracers available for positron emission tomography, molecular, and medical imaging applications. Following a brief summary of secondary 11 C-precursor production and uses, the review focuses on recent progress with direct 11 C-carboxylation routes with [ 11 C]CO 2 and 11 C-carbonylation with [ 11 C]CO. Novel approaches to generate [ 11 C]CO using CO-releasing molecules (CO-RMs), such as silacarboxylic acids and disilanes, applied to radiochemistry are described and compared with standard [ 11 C]CO production methods. These innovative [ 11 C]CO synthesis strategies represent efficient and reliable [ 11 C]CO production processes, enabling the widespread use of [ 11 C]CO chemistry within the wider radiochemistry community., (Copyright © 2017 John Wiley & Sons, Ltd.)

Published
2018
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35. Palladium-mediated oxidative carbonylation reactions for the synthesis of (11) C-radiolabelled ureas.

Author

Kealey S, Husbands SM, Bennacef I, Gee AD, and Passchier J

Subjects
Benzimidazoles, Carbon Radioisotopes, Catalysis, Isotope Labeling, Oxidation-Reduction, Carbon Monoxide chemistry, Palladium chemistry, Radiochemistry methods, Urea chemistry
Abstract

Palladium(II)-mediated oxidative carbonylation reactions have been used to synthesize (11) C-radiolabelled ureas via the coupling of amines with [(11) C]carbon monoxide, in a one-pot process. Following trapping of (11) CO in a solution of copper(I) tris(3,5-dimethylpyrazolyl)borate, homocoupling reactions of primary aliphatic amines proceed in the presence of Pd(PPh3 )2 Cl2 to give the corresponding N,N-disubstituted [(11) C]ureas. Secondary amines do not produce the corresponding N,N,N,N-tetrasubsituted [(11) C]ureas under these conditions. This difference in reactivity allows for the formation of unsymmetrical N,N',N'-trisubstituted [(11) C]ureas using a mixture of a primary amine and a reactive secondary amine. The potential use of this method in positron emission tomography (PET) was demonstrated by the synthesis of the M1 muscarinic acetylcholine receptor radiotracer, [(11) C-carbonyl]GSK1034702., (Copyright © 2013 John Wiley & Sons, Ltd.)

Published
2014
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36. Ab initio computational study of positron emission tomography ligands interacting with lipid molecule for the prediction of nonspecific binding.

Author

Rosso L, Gee AD, and Gould IR

Subjects
Humans, Ligands, Membrane Lipids metabolism, Models, Molecular, Molecular Conformation, Quantum Theory, Radiopharmaceuticals metabolism, Radiopharmaceuticals pharmacokinetics, Sensory Receptor Cells metabolism, Substrate Specificity, Membrane Lipids chemistry, Models, Biological, Models, Chemical, Positron-Emission Tomography methods, Radiopharmaceuticals chemistry
Abstract

Nonspecific binding is a poorly understood biological phenomenon of relevance in the study of small molecules interactions in vivo and in drug development. Nonspecific binding is thought to be correlated in part to a molecule's lipophilicity, typically estimated by measuring (or calculating) octanol-water partition coefficient. This is, however, a gross simplification of a complex phenomenon. In this article, we present a computational method whose aim is to help identify positron emission tomography (PET) ligands with low nonspecific binding characteristics by investigating the molecular basis of ligand-membrane interaction. We considered a set consisting of 10 well-studied central nervous system PET radiotracers acting on a variety of molecular targets. Quantum mechanical calculations were used to estimate the strength of the interaction between each drug molecule and one phospholipid molecule commonly present in mammalian membranes. The results indicate a correlation between the computed drug-lipid interaction energy and the in vivo nonspecific distribution volume relative to the free tracer plasma concentration, calculated using standard compartmental modeling for the analysis of PET data. Significantly, the drugs whose interaction with the lipid molecule more favorably possessed, in general, a higher nonspecific binding value, whereas for the drugs taken in consideration in this study, the water-octanol partition coefficient, log P, did not show good predictive power of the nonspecific binding. This study also illustrates how ab initio chemical methods may offer meaningful and unbiased insights for the understanding of the underlying chemical mechanisms in biological systems., (2008 Wiley Periodicals, Inc.)

Published
2008
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