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Your search keyword '"Ge, Weihong"' showing total 17 results
Start Over Author "Ge, Weihong" Publisher wiley
17 results on '"Ge, Weihong"'

3. Copper Increases the Sensitivity of Cholangiocarcinoma Cells to Tripterine by Inhibiting TMX2‐Mediated Unfolded Protein Reaction Activation (Adv. Healthcare Mater. 26/2023)

Author

Liu, Hongwen, primary, Xu, Lei, additional, Zhang, Yiyang, additional, Xie, Yiqiong, additional, Wang, Lishan, additional, Zhou, Yue, additional, Wang, Zhangding, additional, Pan, Yani, additional, Li, Wenying, additional, Xu, Lu, additional, Xu, Xinyun, additional, Wang, Ting, additional, Meng, Kui, additional, He, Jian, additional, Qiu, Yudong, additional, Xu, Guifang, additional, Ge, Weihong, additional, Zhu, Yun, additional, and Wang, Lei, additional

Published
2023
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5. Evidence‐based guideline for the prevention and management of perioperative infection

Author

Wang, Qiaoyu, primary, Cao, Mingnan, additional, Tao, Hua, additional, Fei, Zhimin, additional, Huang, Xiufeng, additional, Liang, Pixia, additional, Liu, Baiyun, additional, Liu, Jianping, additional, Lu, Xiaoyang, additional, Ma, Penglin, additional, Si, Shuyi, additional, Wang, Shuo, additional, Zhang, Yuewei, additional, Zheng, Yingli, additional, Zang, Lei, additional, Chen, Xiao, additional, Dong, Zhanjun, additional, Ge, Weihong, additional, Guo, Wei, additional, Hu, Xin, additional, Huang, Xin, additional, Li, Ling, additional, Liang, Jianshu, additional, Liu, Baoge, additional, Liu, Dong, additional, Liu, Linna, additional, Liu, Songqing, additional, Liu, Xianghong, additional, Miao, Liyan, additional, Ren, Haixia, additional, Shi, Guangzhi, additional, Shi, Luwen, additional, Sun, Shumei, additional, Tao, Xia, additional, Tong, Rongsheng, additional, Wang, Cheng, additional, Wang, Bin, additional, Wang, Jincheng, additional, Wang, Jingwen, additional, Wang, Xiaoling, additional, Wang, Xiaoyan, additional, Xie, Jian, additional, Xie, Shouxia, additional, Yang, Hua, additional, Yang, Jianxin, additional, You, Chao, additional, Zhang, Hongyi, additional, Zhang, Yi, additional, Zhao, Chengson, additional, Zhao, Qingchun, additional, Zhu, Jiangguo, additional, Ji, Bo, additional, Guo, Ruichen, additional, Hang, Chunhua, additional, Xi, Xiaowei, additional, Li, Sheyu, additional, Gong, Zhicheng, additional, Zhou, Jianxin, additional, Wang, Rui, additional, and Zhao, Zhigang, additional

Published
2023
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11. Quantitative assessments reveal improved neuroscience engagement and learning through outreach

Author

Saravanapandian, Vidya, primary, Sparck, Erin M., additional, Cheng, Karen Y., additional, Yu, Fei, additional, Yaeger, Courtney, additional, Hu, Terry, additional, Suthana, Nanthia, additional, Romero‐Calderón, Rafael, additional, Ghiani, Cristina A., additional, Evans, Christopher J., additional, Carpenter, Ellen M., additional, and Ge, Weihong, additional

Published
2019
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16. Population Pharmacokinetics of Voriconazole and Dose Optimization in Elderly Chinese Patients.

Author

Wang J, Shen Y, Wu Z, and Ge W

Subjects
Humans, Aged, Voriconazole, Monte Carlo Method, Administration, Intravenous, China, Antifungal Agents
Abstract

Voriconazole is commonly recommended as a first-line therapy for invasive aspergillosis infections. Elderly patients are susceptible to infectious diseases owing to their decreased physical function and immune system. Our study aims to establish a population pharmacokinetics model for elderly patients receiving intravenous voriconazole, and to optimize dosing protocols through a simulated approach. An accurate fit to the concentration-time profile of voriconazole was achieved by employing a 1-compartment model featuring first-order elimination. The typical clearance rate of voriconazole was found to be 3.22 L/h, with a typical volume of distribution of 194 L. The covariate analysis revealed that albumin (ALB), gamma-glutamyl transpeptidase, and direct bilirubin had significant impacts on voriconazole clearance. Additionally, body weight was found to be associated with the volume of distribution. Individualized dosing regimens were recommended for different ALB levels based on population pharmacokinetics model prediction. The proposed dosing regimens could provide a rationale for dosage individualization, improve the clinical outcomes, and minimize drug-related toxicities., (© 2023, The American College of Clinical Pharmacology.)

Published
2024
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17. Physiologically-based pharmacokinetic pharmacodynamic parent-metabolite model of edoxaban to predict drug-drug-disease interactions: M4 contribution.

Author

Xu R, Liu W, Ge W, He H, and Jiang Q

Subjects
Adult, Humans, Pyridines pharmacokinetics, Drug Interactions, Anticoagulants, Models, Biological, Computer Simulation, Thiazoles pharmacology, Renal Insufficiency metabolism
Abstract

This study aimed to develop a physiologically-based pharmacokinetic pharmacodynamic (PBPK/PD) parent-metabolite model of edoxaban, an oral anticoagulant with a narrow therapeutic index, and to predict pharmacokinetic (PK)/PD profiles and potential drug-drug-disease interactions (DDDIs) in patients with renal impairment. A whole-body PBPK model with a linear additive PD model of edoxaban and its active metabolite M4 was developed and validated in SimCYP for healthy adults with or without interacting drugs. The model was extrapolated to situations including renal impairment and drug-drug interactions (DDIs). Observed PK and PD data in adults were compared with predicted data. The effect of several model parameters on the PK/PD response of edoxaban and M4 was investigated in sensitivity analysis. The PBPK/PD model successfully predicted PK profiles of edoxaban and M4 as well as anticoagulation PD responses with or without the influence of interacting drugs. For patients with renal impairment, the PBPK model successfully predicted the fold change in each impairment group. Inhibitory DDI and renal impairment had a synergistic effect on the increased exposure of edoxaban and M4, and their downstream anticoagulation PD effect. Sensitivity analysis and DDDI simulation show that renal clearance, intestinal P-glycoprotein activity, and hepatic OATP1B1 activity are the major factors affecting edoxaban-M4 PK profiles and PD responses. Anticoagulation effect induced by M4 cannot be ignored when OATP1B1 is inhibited or downregulated. Our study provides a reasonable approach to adjust the dose of edoxaban in several complicated scenarios especially when M4 cannot be ignored due to decreased OATP1B1 activity., (© 2023 The Authors. CPT: Pharmacometrics & Systems Pharmacology published by Wiley Periodicals LLC on behalf of American Society for Clinical Pharmacology and Therapeutics.)

Published
2023
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