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Your search keyword '"Gao, Kui"' showing total 12 results
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12 results on '"Gao, Kui"'

3. Contrast‐enhanced harmonic endoscopic ultrasound (CH‐EUS) MASTER: A novel deep learning‐based system in pancreatic mass diagnosis

Author

Tang, Anliu, primary, Tian, Li, additional, Gao, Kui, additional, Liu, Rui, additional, Hu, Shan, additional, Liu, Jinzhu, additional, Xu, Jiahao, additional, Fu, Tian, additional, Zhang, Zinan, additional, Wang, Wujun, additional, Zeng, Long, additional, Qu, Weiming, additional, Dai, Yong, additional, Hou, Ruirui, additional, Tang, Shoujiang, additional, and Wang, Xiaoyan, additional

Published
2023
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6. First cases of Zika virus-infected US blood donors outside states with areas of active transmission

Author

Williamson, Phillip C., primary, Linnen, Jeffrey M., additional, Kessler, Debra A., additional, Shaz, Beth H., additional, Kamel, Hany, additional, Vassallo, Ralph R., additional, Winkelman, Valerie, additional, Gao, Kui, additional, Ziermann, Rainer, additional, Menezes, Juscilene, additional, Thomas, Stephen, additional, Holmberg, Jerry A., additional, Bakkour, Sonia, additional, Stone, Mars, additional, Lu, Kai, additional, Simmons, Graham, additional, and Busch, Michael P., additional

Published
2017
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8. Xenotropic murine leukemia virus-related virus does not pose a risk to blood recipient safety

Author

Dodd, Roger Y., primary, Hackett Jr, John, additional, Linnen, Jeffrey M., additional, Dorsey, Kerri, additional, Wu, Yanyun, additional, Zou, Shimian, additional, Qiu, Xiaoxing, additional, Swanson, Priscilla, additional, Schochetman, Gerald, additional, Gao, Kui, additional, Carrick, James M., additional, Krysztof, David E., additional, and Stramer, Susan L., additional

Published
2011
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12. Modeling HIV-1 integrase complexes based on their hydrodynamic properties.

Author

Podtelezhnikov AA, Gao K, Bushman FD, and McCammon JA

Subjects
Base Sequence, DNA chemistry, DNA genetics, DNA metabolism, HIV Integrase genetics, Macromolecular Substances, Models, Molecular, Molecular Sequence Data, Mutagenesis, Site-Directed, Protein Structure, Quaternary, Protein Structure, Tertiary, Rotation, HIV Integrase chemistry, HIV Integrase metabolism, HIV-1 enzymology
Abstract

We present a model structure of a candidate tetramer for HIV-1 integrase. The model was built in three steps using data from fluorescence anisotropy, structures of the individual integrase domains, cross-linking data, and other biochemical data. First, the structure of the full-length integrase monomer was modeled using the individual domain structures and the hydrodynamic properties of the full-length protein that were recently measured by fluorescence depolarization. We calculated the rotational correlation times for different arrangements of three integrase domains, revealing that only structures with close proximity among the domains satisfied the experimental data. The orientations of the domains were constrained by iterative tests against the data on cross-linking and footprinting in integrase-DNA complexes. Second, the structure of an integrase dimer was obtained by joining the model monomers in accordance with the available dimeric crystal structures of the catalytic core. The hydrodynamic properties of the dimer were in agreement with the experimental values. Third, the active sites of the two model dimers were placed in agreement with the spacing between the sites of integration on target DNA as well as the integrase-DNA cross-linking data, resulting in twofold symmetry of a tetrameric complex. The model is consistent with the experimental data indicating that the F185K substitution, which is found in the model at a tetramerization interface, selectively disrupts correct complex formation in vitro and HIV replication in vivo. Our model of the integrase tetramer bound to DNA may help to design anti-integrase inhibitors., (Copyright 2002 Wiley Periodicals, Inc. Biopolymers 68: 110-120, 2003)

Published
2003
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