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Anthropogenic stressors are predicted to alter biodiversity and ecosystem functioning worldwide. However, scaling up from species to ecosystem responses poses a challenge, as species and functional groups can exhibit different capacities to adapt, acclimate, and compensate under changing environments. We used a naturally acidified seagrass ecosystem (the endemic Mediterranean Posidonia oceanica) as a model system to examine how ocean acidification (OA) modifies the community structure and functioning of plant detritivores, which play vital roles in the coastal nutrient cycling and food web dynamics. In seagrass beds associated with volcanic CO

By age 2, children are developing foundational language processing skills, such as quickly recognizing words and predicting words before they occur. How do these skills relate to children’s structural knowledge of vocabulary? Multiple aspects of language processing were simultaneously measured in a sample of 2‐to‐5‐year‐olds (N = 215): While older children were more fluent at recognizing words, at predicting words in a graded fashion, and at revising incorrect predictions, only revision was associated with concurrent vocabulary knowledge once age was accounted for. However, an exploratory longitudinal follow‐up (N = 55) then found that word recognition and prediction skills were associated with rate of subsequent vocabulary development, but revision skills were not. We argue that prediction skills may facilitate language learning through enhancing processing speed.

Researchers and practitioners have designed and implemented various automated test case generators to support effective software testing. Such generators exist for various languages (e.g., Java, C#, or Python) and various platforms (e.g., desktop, web, or mobile applications). The generators exhibit varying effectiveness and efficiency, depending on the testing goals they aim to satisfy (e.g., unit-testing of libraries versus system-testing of entire applications) and the underlying techniques they implement. In this context, practitioners need to be able to compare different generators to identify the most suited one for their requirements, while researchers seek to identify future research directions. This can be achieved by systematically executing large-scale evaluations of different generators. However, executing such empirical evaluations is not trivial and requires substantial effort to select appropriate benchmarks, setup the evaluation infrastructure, and collect and analyse the results. In this Software Note, we present our JUnit Generation Benchmarking Infrastructure (JUGE) supporting generators (search-based, random-based, symbolic execution, etc.) seeking to automate the production of unit tests for various purposes (validation, regression testing, fault localization, etc.). The primary goal is to reduce the overall benchmarking effort, ease the comparison of several generators, and enhance the knowledge transfer between academia and industry by standardizing the evaluation and comparison process. Since 2013, several editions of a unit testing tool competition, co-located with the Search-Based Software Testing Workshop, have taken place where JUGE was used and evolved. As a result, an increasing amount of tools (over 10) from academia and industry have been evaluated on JUGE, matured over the years, and allowed the identification of future research directions. Based on the experience gained from the competitions, we discuss the expected impact of JUGE in improving the knowledge transfer on tools and approaches for test generation between academia and industry. Indeed, the JUGE infrastructure demonstrated an implementation design that is flexible enough to enable the integration of additional unit test generation tools, which is practical for developers and allows researchers to experiment with new and advanced unit testing tools and approaches.

Aim A key paradigm of deep-sea ecology is that the ocean interior is a food-limited environment, which limits the faunal growth. Here, we estimated the efficiency of deep-sea fauna in exploiting resources to assess the potential response of deep-sea organisms to changes in the food inputs expected with global change. Location Mediterranean Sea. Time period 1989–2010. Major taxa studied Viruses, prokaryotes, meiofauna, macrofauna and megafauna. Methods Using the largest data set spanning from microbes to megafauna produced synoptically so far, we investigated patterns of abundance, biomass and ecosystem efficiency across depth-related and longitudinal gradients of food availability in both Western and Eastern Basins of the Mediterranean Sea. Results Our results revealed that prokaryotes dominated benthic biomass at depths > 2,000 m. Contrary to what has been reported at a global scale, meiofaunal biomass decreased with increasing water depth more rapidly than macrofauna and megafauna. Meiofauna showed a significant negative log-linear relationship with increasing water depth in the whole Mediterranean Sea, whereas the other benthic components, from viruses to megafauna, did not decrease significantly, decreased or even increased (e.g., prokaryotes) with increasing water depth. Taking all components together, the efficiency of benthic ecosystems in exploiting organic carbon (OC) inputs increased with increasing depth, in both mesotrophic and ultra-oligotrophic conditions of the deep Mediterranean Sea. Main conclusions Changes in ecological efficiency in exploiting the energy available in food-limited conditions suggest that deep-sea ecosystems can show a responsive adaptation to changes in OC inputs from the photic zone. Our results contribute to explaining the high efficiency of resource exploitation by consumers in limited trophic conditions and allow us to hypothesize that the consequences of a potential reduction of food supply in deep-sea ecosystems induced by global changes could be less severe than expected.

Ocean acidification (OA) is likely to exert selective pressure on natural populations. Our ability to predict which marine species will adapt to OA and what underlies this adaptive potential is of high conservation and resource management priority. Using a naturally low‐pH vent site in the Mediterranean Sea (Castello Aragonese, Ischia) mirroring projected future OA conditions, we carried out a reciprocal transplant experiment to investigate the relative importance of phenotypic plasticity and local adaptation in two populations of the sessile, calcifying polychaete Simplaria sp. (Annelida, Serpulidae, Spirorbinae): one residing in low pH and the other from a nearby ambient (i.e. high) pH site. We measured a suite of fitness‐related traits (i.e. survival, reproductive output, maturation, population growth) and tube growth rates in laboratory‐bred F2 generation individuals from both populations reciprocally transplanted back into both ambient and low‐pH in situ habitats. Both populations showed lower expression in all traits, but increased tube growth rates, when exposed to low‐pH compared with high‐pH conditions, regardless of their site of origin suggesting that local adaptation to low‐pH conditions has not occurred. We also found comparable levels of plasticity in the two populations investigated, suggesting no influence of long‐term exposure to low pH on the ability of populations to adjust their phenotype. Despite high variation in trait values among sites and the relatively extreme conditions at the low pH site (pH

Spread of alien species (AS) is a serious threat to marine habitats and analysis of principal descriptors of their occurrence is pivotal to set reliable conservation strategies. 2. In order to assess the susceptibility of marine habitats to biological invasions, a dataset was gathered of the occurrence of 3899 species from 29 phyla, taken from 93 marine sites located along the Italian coast in the period 2000-2012.

To what extent are linguistic representations shared between production and comprehension? What is the nature of the links between production and comprehension processes? In this chapter, we provide an introduction to those models that incorporate explicit assumptions about the degree of sharing and review some supporting evidence. We show that full sharing of representations is uncontroversial only for semantics and syntax, while there is mixed evidence over the degree of overlapping at the level of phonological and phonetic representations. We then propose a taxonomy of production‐comprehension links, ranging from long‐term to fast‐acting. To conclude, we advocate more explicit theorizing about the relationship between language production and language comprehension.

Recently, Irani and colleagues proposed a C-terminal cleaved isoform cystatin C (12.5kDa) in cerebrospinal fluid as a marker of multiple sclerosis. In this study, we demonstrate that the 12.5kDa product of cystatin C is formed by degradation of the first eight N-terminal residues. Moreover, such a degradation is not specific in the cerebrospinal fluid of multiple sclerosis, but rather is given by an inappropriate sample storage at −20°C. We conclude that the use of the 12.5kDa product of cystatin C in cerebrospinal fluid might lead to a fallacious diagnosis of multiple sclerosis. Preanalytical validation procedure is mandatory for proteomics investigations. Ann Neurol 2007

We describe the clinical and molecular correlates in two Italian families with dopa-responsive dystonia (DRD) and the same novel mutation of GTP-cyclohydrolase I (GCH-I) gene. Thirty-five subjects were examined and the genotype correlated to phenotype. Childhood onset foot dystonia is present in 7 subjects currently under the age of 40. In 1 patient bilateral foot dystonia was evident at birth suggesting that dystonia may be active as early as in utero. In another patient, dystonia spontaneously remitted in adolescence, to relapse 8 years later, as writer's cramp. Dystonia and parkinsonian signs are present in 5 other patients. In 2 subjects an isolated parkinsonism started over the age of 45. A 5-base pair insertion at codon 242 within exon 6 of GTP-cyclohydrolase I (GCH-I) gene that shifts the reading frame and results in a premature stop at codon 247 with truncation of the polypeptide has been detected in 21 subjects. Considering dystonia and parkinsonism the overall penetrance is 0.71 and not significantly different in men (0.69) and women (0.75). Genealogical studies seem to exclude that these families are related but haplotype analysis suggests a single founder. Our findings in subjects with the same mutation indicate a wide intrafamilial variation in expressivity and high penetrance in DRD but do not confirm the reported influence of gender on GCH-I gene mutation penetrance.

Aim Understanding how biodiversity varies at different spatial scales and the drivers behind these patterns is a crucial issue in ecology. This is evident for the deep sea, the largest biome of the biosphere, where there is little information available on the spatial and temporal variability of biodiversity. Here, we investigated the variability and potential drivers of species richness, turnover and functional biodiversity of deep-sea nematodes at a depth of 3000 m across different spatial scales and in two periods of contrasting pelagic productivity. Location The Mediterranean Sea. Methods We used for the first time a hierarchical sampling strategy that includes different spatial scales, from tens of metres (small scale) to hundreds of kilometres (macroscale). Results We show that the variability in biodiversity is greatest at the macroscale, although the rate of variability is about two- to three-fold lower than observed for nematode abundance. Also, turnover diversity is highest at the macroscale (and uncoupled from species richness), and significantly decreases to the meso- and local scales. Functional diversity is positively related to species richness and its variability is associated with the change in richness of predators. The drivers of spatial variability of biodiversity are different at different spatial scales. Our data identify the pivotal role of food quantity in the control of variability in biodiversity attributes at the macroscale, while the quality and bioavailability of food sources have a key role in driving beta diversity and biodiversity attributes at small spatial scales.Also, the largest variations in biodiversity attributes at both macroscales and mesoscales are related to periods of high food input from the euphotic zone.

Effective ecosystem-based management requires understanding ecosystem responses to multiple human threats, rather than focusing on single threats. To understand ecosystem responses to anthropogenic threats holistically, it is necessary to know how threats affect different components within ecosystems and ultimately alter ecosystem functioning. We used a case study of a Mediterranean seagrass (Posidonia oceanica) food web and expert knowledge elicitation in an application of the initial steps of a framework for assessment of cumulative human impacts on food webs. We produced a conceptual seagrass food web model, determined the main trophic relationships, identified the main threats to the food web components, and assessed the components’ vulnerability to those threats. Some threats had high (e.g., coastal infrastructure) or low impacts (e.g., agricultural runoff) on all food web components, whereas others (e.g., introduced carnivores) had very different impacts on each component. Partitioning the ecosystem into its components enabled us to identify threats previously overlooked and to reevaluate the importance of threats commonly perceived as major. By incorporating this understanding of system vulnerability with data on changes in the state of each threat (e.g., decreasing domestic pollution and increasing fishing) into a food web model, managers may be better able to estimate and predict cumulative human impacts on ecosystems and to prioritize conservation actions. El manejo efectivo con base en los ecosistemas requiere entender la respuesta de los ecosistemas a múltiples amenazas humanas en lugar de enfocarse en amenazas individuales. Para entender holísticamente la respuesta de los ecosistemas a las múltiples amenazas antropogénicas es necesario saber cómo estas amenazas afectan a los diferentes componentes dentro de los ecosistemas y cómo alteran finalmente el funcionamiento de los ecosistemas. Usamos el estudio de caso de la red alimenticia del pasto marino del Mediterráneo (Posidonia oceanica) y la obtención de conocimiento de expertos en una aplicación de los pasos iniciales de un método para la evaluación de los impactos humanos acumulativos sobre las redes alimenticias. Produjimos un modelo de red alimenticia de pastos marinos, determinamos las principales relaciones tróficas, identificamos a las principales amenazas para los componentes de la red y evaluamos la vulnerabilidad de los componentes a esas amenazas. Algunas amenazas tuvieron impactos altos (p. ej.: infraestructura costera) o bajos (p. ej.: escorrentía agrícola) sobre todos los componentes de la red, mientras que otros (p. ej.: carnívoros introducidos) tuvieron impactos muy diferentes sobre cada componente. Partir al ecosistema en sus componentes nos permitió identificar amenazas no vistas previamente y reevaluar la importancia de las amenazas percibidas comúnmente como mayores. Al incorporar este entendimiento de la vulnerabilidad del sistema con datos sobre los cambios en el estado de cada amenaza (p. ej.: disminución de la contaminación doméstica e incremento de la pesca) al modelo de red alimenticia, los manejadores pueden ser capaces de estimar y predecir de mejor manera los impactos humanos acumulativos sobre los ecosistemas y priorizar las acciones de conservación. This work is a contribution of the project “NETMED” co-financed by the Greek State and the European Social Fund. Workshop funding was provided by ARC CEED-University of Queensland, the University of Liège, and STARESO. M.C. was supported by EC Marie Curie CIG grant to BIOWEB. This paper contributes to MARE publications (no. 282).

Sepede G, De Berardis D, Campanella D, Perrucci MG, Ferretti A, Serroni N, Moschetta FS, Del Gratta C, Salerno RM, Ferro FM, Di Giannantonio M, Onofrj M, Romani GL, Gambi F. Impaired sustained attention in euthymic bipolar disorder patients and non-affected relatives: an fMRI study. Bipolar Disord 2012: 14: 764–779. © 2012 The Authors. Journal compilation © 2012 John Wiley & Sons A/S. Objective: Behavioral deficits in sustained attention have been reported during both acute and euthymic phases of type I bipolar disorder (BD-I) and also in non-affected relatives of bipolar disorder (BD) patients. In particular, selective failure in target recognition was proposed as a potential trait marker for BD, but there are few studies exploring the neural correlates. The aim of the present study was to analyze the behavioral and functional magnetic resonance imaging (fMRI) response of euthymic BD-I patients and non-affected relatives during a sustained attention task. Methods: Twenty-four euthymic BD-I patients, 22 non-affected first-degree relatives of BD-I subjects, and 24 matched controls underwent a continuous performance test (CPT) with two levels of difficulty during event-related fMRI scanning. Results: Both patients and relatives showed a lower accuracy in target detection when compared to controls. The fMRI data analysis revealed between-group differences in several brain regions involved in sustained attention. During error in target recognition, both patients and relatives showed a larger activation in the bilateral insula and the posterior part of the middle cingulate cortex. By contrast, during correct target response, only patients failed to activate the right insula, whereas relatives showed an increased activation of the left insula and bilateral inferior parietal lobule – limited to the higher attention load – and an augmented deactivation of the posterior cingulate/retrosplenial cortex. Conclusions: A selective impairment in target recognition during a CPT was behaviorally and functionally detectable in both euthymic BD-I patients and non-affected first-degree relatives, suggesting that specific sustained attention deficits may be a potential trait marker for BD-I.

Ionic surfactants such as sodium dodecyl sulfate (SDS) belong to the amphiphile family: they possess a long hydrophobic hydrocarbon chain and a polar hydrophilic headgroup. In a polar solvent and over the critical micellar concentration these molecules join to form micelles. The micellar solutions, in turn, if doped with various ligands tend to aggregate. Solid SDS, micelles of SDS in water and micelles of SDS doped with two types of macrocyclic ligands, Kryptofix 2.2.2 (K222) and crown ether 18-Crown-6 (18C6), at different concentrations are studied by Raman scattering, that represents a new approach to such systems. The experimental Raman spectrum, obtained on crystalline powders of SDS, is compared with the ab initio computed spectrum in order to assign the vibrational bands. After discriminating sensitive peaks by comparing the crystalline powders of the single components and their water solutions, the aggregation process and the action of the ligands are analyzed following the evolution of the intensity and wavenumber of these characteristic Raman peaks. This shows that Raman spectroscopy is sensitive to the aggregation dynamics and to the effects induced by the hydration layer on the molecules in solutions. A saturation effect in the aggregation process with the increase of the ligand concentration is observed. Copyright © 2012 John Wiley & Sons, Ltd.

The spread of the introduced chlorophyte alga Caulerpa racemosa (with its variety cylindracea) in the Mediterranean Sea has been dramatic in the past decade due to its ability to cover substantial bottom areas and modify invaded habitats. From its first appearance in the mid-1990s, C. racemosa var. cylindracea has proliferated along the soft bottom of the Gulf of Salerno (Tyrrhenian Sea), which in its central part was largely unvegetated. A long-term assessment of the macrofaunal assemblages from this area was conducted based on a comparison between a historical dataset of macrofaunal species and abundances obtained in 1981, before the introduction of the alga, and datasets derived from sampling performed in 2006 and 2007 at the same stations. The aim of the comparison was to explore whether a detectable change occurred in the degree of diversity and in the composition of macrofaunal assemblages and, if this occurred, whether such change could be attributed, at least in part, to the C. racemosa colonization in the area. Although overall local diversity did not change in the study area, the composition of the macrofaunal assemblages in 2006–2007 differed from that in 1981. The most conspicuous changes were a decline in infaunal bivalve molluscs and an increase of mobile epibenthic forms (notably the mollusc Nassarius pygmaeus); these may be linked to the influence of C. racemosa on sediment properties. The dominance of some species (mainly polychaetes) may be associated with other environmental factors such as the intensity of riverine inputs. The impact of the invasive alga appears to vary according to the habitat invaded.

The possible effects of ocean acidification on the calcareous skeleton of the Mediterranean bryozoan Myriapora truncata (Pallas, 1766) were studied by transplanting live and dead colonies into an area of natural volcanic CO2 vents at Ischia (Gulf of Naples, Tyrrhenian Sea), Italy. Morphology and geochemistry were compared between colonies from normal (mean pH = 8.07, min. pH 7.95), below-normal (mean pH 7.66, min. pH 7.32) and acidic (mean pH 7.43, min. pH 6.83) conditions after colonies had been exposed in situ for 45 and 128 days. Both distal (juvenile) and proximal (adult) parts of the branches were investigated. Skeletons of live colonies in acidic pH site after 45 days of exposure were less corroded than those of dead colonies, suggesting that the organic tissues enveloping the skeleton play a protective role. Colonies remained alive at the below-normal and acidic pH sites during the 45-day experiment but corrosion was very striking after 128 days, with colonies from the acidic site showing significant loss of skeleton. Compared to the control, these colonies also had lower levels of Mg (mean 8 versus 9.5 wt% Mg) within their skeletons. Electron microprobe mapping showed Mg to be higher in the outer layers of the skeletal walls in colonies from the normal pH site. Corrosion of outer layers of the walls probably explains the lower Mg level found in colonies exposed to acidic conditions. As solubility of calcite increases with Mg content, the enrichment of Mg in outer layers of the skeleton should enhance the vulnerability of Myriapora truncata to dissolution. These findings raise concerns over the survival of bryozoans with Mg calcite skeletons in the face of predicted decreases in oceanic pH levels.

To investigate the possible efficacy of amantadine in the control of pathological gambling (PG) associated with Parkinson disease (PD), 17 PD patients with PG were randomly selected for a double-blind crossover study with amantadine 200mg/day versus placebo and an open follow-up. Assessments included PG-specific scales (Yale-Brown Obsessive-Compulsive Scale for PG, Gambling-Symptom Assessment Scale, South Oaks Gambling Screen) and assessment of expenditures and time spent gambling. Amantadine abolished or reduced PG in all treated patients, as confirmed by scale score and daily expenditure reduction. Amantadine might be useful to treat PG. The effect of amantadine, acting as an antiglutamatergic agent, also opens new insights into the pathogenesis of PG.

The great variety of geological and hydrological conditions in the deep sea generates many different habitats. Some are only recently explored, although their true extent and geographical coverage are still not fully established. Both continental margins and mid-oceanic seafloors are much more complex ecologically, geologically, chemically and hydrodynamically than originally thought. As a result, fundamental patterns of species distribution first observed and explained in the context of relatively monotonous slopes and abyssal plains must now be re-evaluated in the light of this newly recognized habitat heterogeneity. Based on a global database of nematode genus composition, collected as part of the Census of Marine Life, we show that macrohabitat heterogeneity contributes significantly to total deep-sea nematode diversity on a global scale. Different deep-sea settings harbour specific nematode assemblages. Some of them, like coral rubble zones or nodule areas, are very diverse habitats. Factors such as increased substrate complexity in the case of nodules and corals seem to facilitate the co-existence of a large number of genera with different modes of life, ranging from sediment dwelling to epifaunal. Furthermore, strong biochemical gradients in the case of vents or seeps are responsible for the success of particular genera, which are not prominent in more typical soft sediments. Many nematode deep-sea genera are cosmopolitan, inhabiting a variety of deep-sea habitats and oceans, whereas only 21% of all deep-sea genera recorded are restricted to a single habitat. In addition to habitat heterogeneity, regional differences are important in structuring nematode assemblages. For instance, seeps from different regions yield different genera that thrive on the sulphidic sediments. This study also shows that many areas and habitats remain highly under-sampled, affecting our ability to understand fully the contribution of habitat heterogeneity versus regional differences to global nematode diversity.

The knowledge of the processes controlling the spatial distribution of species diversity is one of the main challenges of the present ecological research. Spatial patterns of benthic biodiversity in the deep sea are poorly known in comparison with other ecosystems and this limits our understanding of the mechanisms controlling the distribution and maintenance of high biodiversity in the largest ecosystems of our biosphere. Although the Mediterranean basin covers 7.5% of the global biodiversity. The high biogeographic complexity and the presence of steep ecological gradients contribute in making the Mediterranean a region of very high diversity. Here we report the results of an investigation on the patterns of nematode biodiversity in the deep-Mediterranean Sea, in relation with bathymetric, longitudinal and energetic gradients. Our results indicate that benthic biodiversity in the deep-Mediterranean decreases significantly with increasing depth. Moreover, at equally deep sites, nematode diversity decreased from the western to the eastern basin and longitudinal gradients were evident when comparing sites at 4000-m depth, with 3000-m depth. The analysis of the available energy (measured as labile organic matter content of the sediments) suggests that biodiversity patterns are not controlled by the amounts of food resources, but instead bio-availability is the key factor. A more detailed analysis revealed an extremely high deep-sea beta-diversity (turnover diversity), both among sites at different depths as well as at similar depths of different longitude or within the same basin. This new finding has not only important implications on the estimates of the overall regional diversity (gamma diversity), but also suggests the presence of high biogeographic complexity in the deep benthic domain of the Mediterranean Sea.

Perkinsiana antarctica (Kinberg, 1867) and P. littoralis (Hartman, 1967) are redescribed form holo- and topotypes. Two new species, P. milae and P. borsibrunoi, are described from the Ross Sea (Antarctica) and compared with other species of the genus. Records of P. antarctica are numerous, but re- examination indicates that many of these represent misidentifications: the species may have a distribution limited to subantarctic areas.

The meadows of the Mediterranean endemic seagrass Posidonia oceanica exhibit relatively high variations of structural and biometric features at various spatial scales. An investigation performed in 1992 in the meadow off Lacco Ameno (Island of Ischia, Gulf of Naples, Italy) detected peculiar spatial patterns of plant distribution, characterized by nestlike structures with radially increasing or decreasing shoot densities. Eight years later (2000), geo-referenced collections at selected points were repeated to trace the temporal variations of shoot density and investigate the recurrence of the density cores previously detected. In addition, shoots for molecular analyses were collected to check the hypothesis that nestlike patterns exhibit highest levels of genetic variability, due to the confluence of several genetically distinct stolons. The 2000 survey confirmed the presence of the main density cores detected in 1992, although their spatial distribution was slightly shifted and a general decrease of spatial anisotropy was observed, probably due to an increased disturbance, mainly due to pleasure boat anchoring. Patterns of genetic diversity showed a more complex picture, well related to the shoot density spatial pattern, especially when compared with the previous 1992 survey. Patterns of genetic diversity confirmed our previous hypotheses on the genesis of shoot density cores, suggesting they are produced over long time, due to a slow stolonization process and a convergence of different genotypes. Regression of the meadow and decrease of density may lead, in short periods, to a homogenization of the density patterns, while genetic diversity cores represent a long-term ‘memory’ of their previous distribution.

Objective The current study elucidates the relations between alexithymia and body image in patients with binge eating disorder (BED). Method One hundred one patients with BED were evaluated. Alexithymia was measured with the Toronto Alexithymia Scale (TAS-20). The severity of BED was measured with the Binge Eating Scale (BES). Body concerns were assessed with the Body Shape Questionnaire-Short Version (BSQ-S), the Body Uneasiness Test (BUT), and the Body Attitude Test (BAT). Additional measures were the Rosenberg Self-Esteem Scale (RSES) and the Beck Depression Inventory (BDI). Results The prevalence of alexithymia in our sample was 39.6% (n = 40) and individuals with alexithymia showed higher scores on all rating scales. Higher body dissatisfaction, lower self-esteem, depressive symptoms, and the Difficulty in Identifying Feelings/Difficulty in Describing Feelings subscales of the TAS-20 were predictors of the severity of BED in the linear regression analysis. Conclusion Alexithymia was associated with more severe BED. Individuals with alexithymia and BED exhibited significantly poorer appearance evaluation and body satisfaction as well as higher depressive symptoms than individuals without alexithymia. © 2006 by Wiley Periodicals, Inc., Int J Eat Disord, 2006

Relatively few studies have characterized basal content and variability of arsenic in polychaetes, despite the potential importance of this element as a pollutant of marine environments. Even less have investigated the chemical speciation of arsenic, occurring as inorganic and organic forms, which reflect a different biological reactivity of the element. In the present paper we integrate existing literature with new data in order to summarize the status quo on arsenic bioaccumulation in polychaetes. We consider species with different trophic habits, phylogenetic relationships, geographic distribution and ecology. Reported data indicate a high variability in arsenic concentration with levels ranging from

We discuss some typical procedures to measure the efficiency of telecommand authentication systems in space missions. As a case-study, the Packet Telecommand Standard used by the European Space Agency is considered. It is shown that, although acceptable under well consolidated evaluation suites, the standard presents some flaws particularly in regard to the randomness level of the pre-signature. For this reason, some possible changes are proposed and evaluated that should be able to improve performance, even reducing the on-board elaboration time.

This paper presents a possible implementation of a Packet over very high bit rate digital subscriber line protocol with reduced impact of the overhead when transmitting Internet protocol packets. The proposal relates to some shared opinions about the inefficiency of the asynchronous transfer mode (ATM) layer when used to transport this kind of packets, and it is based on proper adaptation of previous recommendations and standards. It is numerically shown that a significant throughput increase is achieved when the new protocol is used in place of the current ATM adaptation layer type 5/ATM protocol. Copyright © 2004 John Wiley & Sons, Ltd.

Three tin(IV) complexes of 2-benzoylpyridine N(4)-phenylthiosemicarbazone (H2Bz4Ph) were prepared: [Sn(L)Cl3] (1), [BuSn(L)Cl2] (2) and [(Bu)2Sn(L)Cl] (3), in which L stands for the anionic ligand formed upon complexation with deprotonation and release of HCl. The complexes were characterized by a number of spectroscopic techniques. The crystal structures of H2Bz4Ph and complex 3 were determined. The antifungal activity of the ligand and its tin(IV) complexes was tested against Candida albicans. The thiosemicarbazone proved to be more active than the tin(IV) complexes. Copyright © 2003 John Wiley & Sons, Ltd.

A 20-year-old man with mild myopathy, external ophthalmoparesis, epilepsy, and diffuse white matter hyperintensity in the brain on magnetic resonance imaging had partial merosin deficiency in muscle and absent merosin in the endoneurium. Motor and sensory nerve conduction velocities were slow. Nerve biopsy showed reduction of large myelinated fibers, short internodes, enlarged nodes, excessive variability of myelin thickness, tomacula, and uncompacted myelin, but no evidence of segmental demyelination, naked axons, or onion bulbs. Thus, in congenital muscular dystrophy, merosin expression may be dissociated in different tissues, and the neuropathy is sensory-motor and due to abnormal myelinogenesis.

Background. To evaluate the effect of antenatal tocolytic administration of magnesium sulphate and ritodrine on the cerebral blood flow velocity and on the cerebral vascular resistance of preterm newborns in the first hours of life. Methods. Cerebral blood flow velocity, resistance index and relative vascular resistance were studied in 27 preterm infants (