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49 results on '"GUZMÁN, CARLOS"'

5. Analysis of starch structure and functional properties of tetraploid wheat (Triticum turgidum L.) with differing waxy protein composition

Author

Karim, Hassan, primary, Kumar, Sujon, additional, Lan, Jingyu, additional, Tang, Huaping, additional, Guzmán, Carlos, additional, Xu, Qiang, additional, Zhang, Yazhou, additional, Qi, Pengfei, additional, Deng, Mei, additional, Ma, Jian, additional, Wang, Jirui, additional, Chen, Guoyue, additional, Lan, Xiujin, additional, Wei, Yuming, additional, Zheng, Youliang, additional, and Jiang, Qiantao, additional

Published
2022
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7. A single base change at exon of Wx‐A1 caused gene inactivation and starch properties modified in a wheat EMS mutant line

Author

Zhang, Xuteng, primary, Karim, Hassan, additional, Feng, Xiuqin, additional, Lan, Jingyu, additional, Tang, Huaping, additional, Guzmán, Carlos, additional, Xu, Qiang, additional, Zhang, Yazhou, additional, Qi, Pengfei, additional, Deng, Mei, additional, Ma, Jian, additional, Wang, Jirui, additional, Chen, Guoyue, additional, Lan, Xiujin, additional, Wei, Yuming, additional, Zheng, Youliang, additional, and Jiang, Qiantao, additional

Published
2021
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16. A study of Chitosan and c‐di‐GMP as mucosal adjuvants for intranasal influenza H5N1 vaccine

Author

Svindland, Signe C., primary, Pedersen, Gabriel K., additional, Pathirana, Rishi D., additional, Bredholt, Geir, additional, Nøstbakken, Jane K., additional, Jul‐Larsen, Åsne, additional, Guzmán, Carlos A., additional, Montomoli, Emanuele, additional, Lapini, Giulia, additional, Piccirella, Simona, additional, Jabbal‐Gill, Inderjit, additional, Hinchcliffe, Michael, additional, and Cox, Rebecca J., additional

Published
2012
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31. Efficient mucosal delivery of the HIV-1 Tat protein using the synthetic lipopeptide MALP-2 as adjuvant

Author

Borsutzky, Stefan, primary, Fiorelli, Valeria, additional, Ebensen, Thomas, additional, Tripiciano, Antonella, additional, Rharbaoui, Faiza, additional, Scoglio, Arianna, additional, Link, Claudia, additional, Nappi, Filomena, additional, Morr, Michael, additional, Buttó, Stefano, additional, Cafaro, Aurelio, additional, Mühlradt, Peter F., additional, Ensoli, Barbara, additional, and Guzmán, Carlos A., additional

Published
2003
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48. A study of Chitosan and c-di-GMP as mucosal adjuvants for intranasal influenza H5N1 vaccine.

Author

Svindland SC, Pedersen GK, Pathirana RD, Bredholt G, Nøstbakken JK, Jul-Larsen Å, Guzmán CA, Montomoli E, Lapini G, Piccirella S, Jabbal-Gill I, Hinchcliffe M, and Cox RJ

Subjects
Administration, Intranasal, Animal Experimentation, Animals, Antibodies, Viral blood, CD4-Positive T-Lymphocytes immunology, Cyclic GMP administration & dosage, Cytokines metabolism, Female, Hemagglutination Inhibition Tests, Mice, Mice, Inbred BALB C, Adjuvants, Immunologic administration & dosage, Chitosan administration & dosage, Cyclic GMP analogs & derivatives, Influenza A Virus, H5N1 Subtype immunology, Influenza Vaccines administration & dosage, Influenza Vaccines immunology, Vaccination methods
Abstract

Background: Highly pathogenic avian influenza A/H5N1 virus remains a potential pandemic threat, and it is essential to continue vaccine development against this subtype. A local mucosal immune response in the upper respiratory tract may stop influenza transmission. It is therefore important to develop effective intranasal pandemic influenza vaccines that induce mucosal immunity at the site of viral entry., Objectives: We evaluated the humoral and cellular immune responses of two promising mucosal adjuvants (Chitosan and c-di-GMP) for intranasal influenza H5N1 vaccine in a murine model. Furthermore, we evaluated the concept of co-adjuvanting an experimental adjuvant (c-di-GMP) with chitosan., Methods: BALB/c mice were intranasally immunised with two doses of subunit NIBRG-14 (H5N1) vaccine (7·5, 1·5 or 0·3 μg haemagglutinin (HA) adjuvanted with chitosan (CSN), c-di-GMP or both adjuvants., Results: All adjuvant formulations improved the serum and local antibody responses, with the highest responses observed in the 7·5 μg HA CSN and c-di-GMP-adjuvanted groups. The c-di-GMP provided dose sparing with protective single radial haemolysis (SRH), and haemagglutination inhibition (HI) antibody responses found in the 0·3 μg HA group. CSN elicited a Th2 response, whereas c-di-GMP induced higher frequencies of virus-specific CD4+T cells producing one or more Th1 cytokines (IFN-γ+, IL-2+, TNF-α+). A combination of the two adjuvants demonstrated effectiveness at 7·5 μg HA and triggered a more balanced Th cytokine profile., Conclusion: These data show that combining adjuvants can modulate the Th response and in combination with ongoing studies of adjuvanted intranasal vaccines will dictate the way forward for optimal mucosal influenza vaccines., (© 2012 John Wiley & Sons Ltd.)

Published
2013
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49. Post-training cocaine exposure facilitates spatial memory consolidation in C57BL/6 mice.

Author

Iñiguez SD, Charntikov S, Baella SA, Herbert MS, Bolaños-Guzmán CA, and Crawford CA

Subjects
Animals, Cocaine administration & dosage, Cyclic AMP-Dependent Protein Kinases metabolism, Dose-Response Relationship, Drug, Female, Hippocampus drug effects, Hippocampus physiology, MAP Kinase Signaling System drug effects, Male, Maze Learning physiology, Memory physiology, Mice, Mice, Inbred C57BL, Phosphorylation, Ribosomal Protein S6 Kinases metabolism, Time Factors, Cocaine pharmacology, Maze Learning drug effects, Memory drug effects
Abstract

In this study, we examined the ability of post-training injections of cocaine to facilitate spatial memory performance using the Morris water maze (MWM). We also investigated the role that hippocampal protein kinase A (PKA) and extracellular signal-regulated kinase 1/2 (ERK) signaling may play in cocaine-mediated spatial memory consolidation processes. Male and female C57BL/6 mice were first trained in a MWM task (eight consecutive trials) then injected with cocaine (0, 1.25, 2.5, 5, or 20 mg/kg), and memory for the platform location was retested after a 24 h delay. Cocaine had a dose-dependent effect on spatial memory performance because only the mice receiving 2.5 mg/kg cocaine displayed a significant reduction in latency to locate the platform. No sex differences in MWM performance were observed; however, females showed higher hippocampal levels of PKA when compared with males. A second experiment demonstrated that 2.5 mg/kg cocaine enhanced MWM performance only when administered within 2, but not 4 h after spatial training. We also found that cocaine (2.5 mg/kg) increased ERK2 phosphorylation within the hippocampus and one of its downstream targets (ribosomal S6 kinase), a mechanism that may be responsible, at least in part, for the enhanced cocaine-mediated spatial memory performance. Overall, these data demonstrate that a low dose of cocaine (2.5 mg/kg) administered within 2 h after training facilitates MWM spatial memory performance in C57BL/6 mice., (Copyright © 2011 Wiley Periodicals, Inc.)

Published
2012
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