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Start Over Descriptor "GPI-Linked Protein" Publisher wiley
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1. Growth factor-induced release of a glycosyl-phosphatidylinositol (GPI)-linked protein from the HEp-2 human carcinoma cell line

Author

Paul Kenton, Julia M. Roberts, and Peter M. Johnson

Subjects
GTP', Glycosylphosphatidylinositols, G protein, medicine.medical_treatment, Biophysics, Endogeny, Biology, Phosphatidylinositols, Biochemistry, GTP-Binding Proteins, Structural Biology, Tumor cell, Tumor Cells, Cultured, Genetics, medicine, Humans, Insulin, Laryngeal Neoplasms, Molecular Biology, Epidermal Growth Factor, Phospholipase C, Binding protein, Growth factor, Placental type alkaline phosphatase, Cell Biology, GPI-linked protein, Protein-Tyrosine Kinases, Alkaline Phosphatase, Enzymes, Cell biology, Enzyme Activation, ErbB Receptors, Isoenzymes, Cell culture, embryonic structures, Alkaline phosphatase, Glycolipids
Abstract

The release of a GPI-linked oncofetal protein (PLAP) from HEp-2 cells has been studied as an indicator of endogenous PI-specific PLC activation. A non-hydrolysable GTP analogue, EGF and insulin all produced a dose-dependent release of PLAP from these cells. This indicates that an increase in PLC activity following either growth factor binding or G protein activation may cause cellular release of PLAP.

Published
1990

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