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6 results on '"Fung, Chunkit"'

3. Effects of a Home‐based Exercise Program on Anxiety and Mood Disturbances in Older Adults with Cancer Receiving Chemotherapy

Author

Loh, Kah Poh, primary, Kleckner, Ian R., additional, Lin, Po‐Ju, additional, Mohile, Supriya G., additional, Canin, Beverly E., additional, Flannery, Marie A., additional, Fung, Chunkit, additional, Dunne, Richard F., additional, Bautista, Javier, additional, Culakova, Eva, additional, Kleckner, Amber S., additional, Peppone, Luke J., additional, Janelsins, Michelle, additional, McHugh, Colin, additional, Conlin, Alison, additional, Cho, Jonathan K., additional, Kasbari, Sameer, additional, Esparaz, Benjamin T., additional, Kuebler, J. Philip, additional, and Mustian, Karen M., additional

Published
2019
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4. Management and outcomes of patients with renal medullary carcinoma: a multicentre collaborative study

Author

Shah, Amishi Y., primary, Karam, Jose A., additional, Malouf, Gabriel G., additional, Rao, Priya, additional, Lim, Zita D., additional, Jonasch, Eric, additional, Xiao, Lianchun, additional, Gao, Jianjun, additional, Vaishampayan, Ulka N., additional, Heng, Daniel Y., additional, Plimack, Elizabeth R., additional, Guancial, Elizabeth A., additional, Fung, Chunkit, additional, Lowas, Stefanie R., additional, Tamboli, Pheroze, additional, Sircar, Kanishka, additional, Matin, Surena F., additional, Kimryn Rathmell, W., additional, Wood, Christopher G., additional, and Tannir, Nizar M., additional

Published
2016
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6. High-dose vitamin D to attenuate bone loss in patients with prostate cancer on androgen deprivation therapy: A phase 2 RCT.

Author

Peppone LJ, Kleckner AS, Fung C, Puzas JE, Reschke JE, Culakova E, Inglis J, Kamen C, Friedberg JW, Janelsins M, Mustian K, Heckler CE, and Mohile S

Subjects
Humans, Male, Aged, Middle Aged, Osteoporosis chemically induced, Osteoporosis prevention & control, Prostatic Neoplasms drug therapy, Vitamin D blood, Vitamin D analogs & derivatives, Vitamin D administration & dosage, Androgen Antagonists adverse effects, Androgen Antagonists administration & dosage, Androgen Antagonists therapeutic use, Bone Density drug effects
Abstract

Background: Androgen deprivation therapy (ADT) inhibits prostate cancer growth. However, ADT causes loss of bone mineral density (BMD) and an increase in fracture risk; effective interventions for ADT-induced bone loss are limited., Methods: A phase 2 randomized controlled trial investigated the feasibility, safety, and preliminary efficacy of high-dose weekly vitamin D (HDVD, 50,000 IU/week) versus placebo for 24 weeks in patients with prostate cancer receiving ADT, with all subjects receiving 600 IU/day vitamin D and 1000 mg/day calcium. Participants were ≥60 years (mean years, 67.7), had a serum 25-hydroxyvitamin D level <32 ng/mL, and initiated ADT within the previous 6 months. At baseline and after intervention, dual-energy x-ray absorptiometry was used to assess BMD, and levels of bone cell, bone formation, and resorption were measured., Results: The HDVD group (N = 29) lost 1.5% BMD at the total hip vs. 4.1% for the low-dose group (N = 30; p = .03) and 1.7% BMD at the femoral neck vs. 4.4% in the low-dose group (p = .06). Stratified analyses showed that, for those with baseline 25-hydroxyvitamin D level <27 ng/mL, the HDVD group lost 2.3% BMD at the total hip vs 7.1% for the low-dose group (p < .01). Those in the HDVD arm showed significant changes in parathyroid hormone (p < .01), osteoprotegerin (p < 0.01), N-terminal telopeptide of type 1 collagen (p < 0.01) and C-terminal telopeptide of type 1 collagen (p < 0.01). No difference in adverse events or toxicity was noted between the groups., Conclusions: HDVD supplementation significantly reduced hip and femoral neck BMD loss, especially for patients with low baseline serum 25-hydroxyvitamin D levels, although demonstrating safety and feasibility in prostate cancer patients on ADT., (© 2024 American Cancer Society.)

Published
2024
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