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Your search keyword '"Fu H"' showing total 174 results
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174 results on '"Fu H"'

1. Development and validation of a risk prediction model for the recurrence of foot ulcer in type 2 diabetes in China: A longitudinal cohort study based on a systematic review and meta-analysis.

Author

Wang, M, Chen, D, Fu, H, Xu, H, Lin, S, Ge, T, Ren, Q, Song, Z, Ding, M, Chang, J, Fan, T, Xing, Q, Sun, M, Li, X, Chen, L, Chang, B, Wang, M, Chen, D, Fu, H, Xu, H, Lin, S, Ge, T, Ren, Q, Song, Z, Ding, M, Chang, J, Fan, T, Xing, Q, Sun, M, Li, X, Chen, L, and Chang, B

Abstract

AIMS: To develop and validate a risk prediction model for Chinese patients with type 2 diabetes with the recurrence of diabetic foot ulcers (DFUs) based on a systematic review and meta-analysis. METHODS: A prospective analysis was performed with 1333 participants and followed up for 60 months. Three models were analysed using a derived cohort. The risk factors were screened using meta-analysis and logistic regression, and the missing variables were interpolated by multiple imputation. The internal validation was performed using the bootstrap procedure, and the validation cohort was applied to the external validation. The performance of the model was evaluated in the area under the discrimination Receiver Operating Characteristic Curve (ROC). Calibration and discrimination methods were used for the validation cohort. The variables were selected according to their clinical and statistical importance to construct the nomograms. RESULTS: Three models were developed and validated. Model 1 included seven social and clinical indicators like sex, diabetes mellitus duration, previous DFU, location of ulcer, smoking, history of amputation, and foot deformity. Model 2 included four more indicators besides those in Model 1, which were statin agents used, antiplatelet agents used, systolic blood pressure, and body mass index. Model 3 added further laboratory indicators to Model 2, such as LDL-C, HbA1C, fibrinogen, and blood urea nitrogen. In the derivation cohort, 20.1% (206/1027) participants with DFU recurred as compared to the validation cohort, which was 38.2% (117/306). The areas under the curve in the derivation cohort for Models 1-3 were 0.781 (0.744-0.817), 0.843 (0.813-0.873), and 0.899 (0.876-0.922), respectively. The Youden indexes for Models 1-3 were 0.430, 0.559, and 0.653, respectively. Model 3 showed the highest sensitivity and specificity. All models performed well for both discrimination and calibration. CONCLUSIONS: Models 1-2 were non-invasive, which indicate

Published
2023

2. TiO2 as second phase in Na3Zr2Si2PO12 to suppress dendrite growth in sodium metal solid-state batteries

Author

Gao, Z, Yang, J, Li, G, Ferber, T, Feng, J, Li, Y, Fu, H, Jaegermann, W, Monroe, C, and Huang, Y

Abstract

Solid-state sodium–metal batteries will not achieve reasonable power density without electrolytes that solve the dendrite (filamentation) problem. Metal-filament formation during plating at ceramic/metal interfaces can cause electrical failure by internal short-circuit or mechanical failure by electrolyte fracture. Herein, an Na3Zr2Si2PO12(NZSP) sodium-ion-conducting NASICON electrolyte in which TiO2is incorporated as an additive is presented, leading to a two-phase composite NZSP(TiO2) with improved density, Young's modulus, hardness, grain structure, and bulk permittivity. These features of NZSP(TiO2) suppress dendrite growth along grain boundaries, microcracks, and micropores. As well as demonstrating ultralow ceramic/Na kinetic resistance with electrochemical measurements, X-ray photoelectron spectroscopy is performed to probe interfacial reaction mechanisms. The TiO2phase forms within grain boundaries and along NZSP surfaces. This modifies the two-phase material's microstructure and improves its electrochemical performance, while also increasing the critical current density for dendrite formation. Design guidelines are discussed to mitigate microscopic defects and dendrites in two-phase ceramic electrolytes.

Published
2022

7. Twin-twin transfusion syndrome is associated with alterations in the metabolic profile of maternal plasma in early gestation: a pilot study

Author

Yang, Y, Wen, L, Han, T-L, Zhang, L, Fu, H, Gan, J, Saffery, R, Tong, C, Li, J, Qi, H, Baker, PN, Kilby, MD, Yang, Y, Wen, L, Han, T-L, Zhang, L, Fu, H, Gan, J, Saffery, R, Tong, C, Li, J, Qi, H, Baker, PN, and Kilby, MD

Abstract

OBJECTIVE: Twin-twin transfusion syndrome (TTTS) causes perinatal mortality and morbidity in monochorionic twins. The early recognition of and interventional therapy for TTTS is associated with a more favorable overall prognosis. However, the prediction by the use of ultrasound in the first trimester has relatively poor sensitivity and specificity. This study aimed to identify metabolic biomarkers to aid in ultrasound screening of TTTS. METHODS: Maternal plasma was prospectively collected between 11 and 15 weeks of gestation in apparently uncomplicated monochorionic-diamniotic twin pregnancies. This cohort was divided into: (i) patients who were subsequently diagnosed with TTTS by using ultrasound; (ii) uncomplicated matched controls. Metabolome was profiled by using gas chromatography-mass spectrometry. RESULTS: The levels of fatty acids, organic acids, oxaloacetic acid, and beta-alanine were significantly lower in the TTTS maternal plasma at 11-15 weeks of gestation, and methionine and glycine were also higher (p < 0.05, FDR<0.12). Generally, in TTTS pregnancies, the metabolisms of amino acid, carbohydrate, cofactors, vitamins, and purine were "down-regulated"; whereas bile secretion and pyrimidine metabolism were "upregulated." CONCLUSIONS: The metabolomics scanning of early gestation maternal plasma may identify those pregnancies that subsequently develop TTTS; in particular, downregulated fatty acid levels may be biologically plausible to be implicated in the pathogenesis of TTTS.

Published
2021

8. Advanced Maternal Age-associated SIRT1 Deficiency Compromises Trophoblast Epithelial-Mesenchymal Transition through an Increase in Vimentin Acetylation

Author

Xiong, L, Ye, X, Chen, Z, Fu, H, Li, S, Xu, P, Yu, J, Wen, L, Gao, R, Fu, Y, Qi, H, Kilby, MD, Saffery, R, Baker, PN, Tong, C, Xiong, L, Ye, X, Chen, Z, Fu, H, Li, S, Xu, P, Yu, J, Wen, L, Gao, R, Fu, Y, Qi, H, Kilby, MD, Saffery, R, Baker, PN, and Tong, C

Abstract

Advanced maternal age (AMA) pregnancies are rapidly increasing and are associated with aberrant trophoblast cell function, poor placentation, and unfavorable pregnancy outcomes, presumably due to premature placental senescence. SIRT1 is an NAD+ -dependent deacetylase with well-known antiaging effects, but its connection with placental senescence is unreported. In this study, human term placentas and first-trimester villi were collected from AMA and normal pregnancies, and a mouse AMA model was established by cross breeding young and aged male and female C57 mice. SIRT1 expression and activity in HTR8/SVneo cells were genetically or pharmacologically manipulated. Trophoblast-specific Sirt1-knockout (KO) mouse placentas were generated by mating Elf5-Cre and Sirt1fl/fl mice. Trophoblast cell mobility was assessed with transwell invasion and wound-healing assays. SIRT1-binding proteins in HTR8/SVneo cells and human placental tissue were identified by mass spectrometry. We identified SIRT1 as the only differentially expressed sirtuin between AMA and normal placentas. It is downregulated in AMA placentas early in the placental life cycle and is barely impacted by paternal age. SIRT1 loss upregulates P53 acetylation and P21 expression and impairs trophoblast invasion and migration. Sirt1-KO mouse placentas exhibit senescence markers and morphological disruption, along with decreased fetal weight. In trophoblasts, SIRT1 interacts with vimentin, regulating its acetylation. In conclusion, SIRT1 promotes trophoblast epithelial-mesenchymal transition (EMT) to enhance invasiveness by modulating vimentin acetylation. AMA placentas are associated with premature senescence during placentation due to SIRT1 loss. Therefore, SIRT1 may be an antiaging therapeutic target for improving placental development and perinatal outcomes in AMA pregnancies.

Published
2021

13. PS1531 INCIDENCE, RISK FACTOR AND OUTCOME OF IMMUNE-MEDIATED NEUROPATHIES FOLLOWING HAPLOIDENTICAL HAEMATOPOIETIC STEM CELL TRANSPLANTATION

Author

Ren, X., primary, Liu, X., additional, Huang, Q., additional, Wang, Q., additional, He, Y., additional, Zhu, X., additional, Han, W., additional, Chen, H., additional, Chen, Y., additional, Wang, F., additional, Wang, J., additional, Zhang, Y., additional, Mo, X., additional, Wang, Y., additional, Fu, H., additional, Chang, Y., additional, Xu, L., additional, Liu, K., additional, Huang, X., additional, and Zhang, X., additional

Published
2019
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26. Genome‐wide SNP discovery and QTL mapping for economic traits in a recombinant inbred line of Oryza sativa

Author

Gengmi Li, Qianhua Yang, Deqiang Li, Tao Zhang, Li Yang, Jian Qin, Bin Tang, Xiaojiao Guo, Yingjiang Cao, Shumei You, Zhaoxiang Li, Jing Luo, Xianqi Wan, Ying Liu, Fu Huang, Longbiao Guo, Kaifeng Jiang, and Jiakui Zheng

Subjects
genetic linkage map, quantitative trait loci, recombinant inbred line, Agriculture, Agriculture (General), S1-972
Abstract

Abstract The objective of the study was to understand the genetic basis of eight traits conferring grain appearance and yield in a recombinant inbred line (RIL8) derived from a cross between cultivated Indica rice varieties Dexiang074B and Pujiang6. We conducted whole genome re‐sequencing for the two parental lines and genotyping by sequencing (GBS) for the RIL8 population. Next, we aligned the clean reads to the rice genome Nipponbare IRGSP 1.0, constructed the genetic linkage map (GLM), and performed the quantitative trait loci (QTL) analysis. In total, 2631 high‐quality markers were generated for 315 RIL8 samples. We identified a rice GLM containing 12 linkage groups (total map distance: 1946.71 cM; average map distance: 0.74 cM) and 98 QTLs related to the rice yield, including 31 high credible QTLs. In addition, 39 QTLs were identified to be associated with the G*E interaction. While most of the QTLs were co‐localized with previously reported rice QTLs, some novel QTLs were identified for the first time in this study. These findings provide a genetic basis for developing cultivated rice with good economic characteristics based on molecular breeding technologies.

Published
2021
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28. Reduced Surgical Time and Higher Accuracy of Distal Locking with the Electromagnetic Targeting System in Humeral Shaft Intramedullary Nailing

Author

Fu Huichao and Wu Xiaoming

Subjects
Distal locking, Electromagnetic targeting system, Humeral shaft fracture, Intramedullary nail, Radiation exposure, Orthopedic surgery, RD701-811
Abstract

Objective To evaluate the efficacy of the electromagnetic distal targeting system in the treatment of humeral shaft fractures. Methods From January 2012 to December 2018, we retrospectively reviewed 60 patients with humeral shaft fractures treated by intramedullary nailing. Among 60 cases, 41 were men and 19 were women. The average age at surgery was 48.5 years (range, 21–81 years). We performed the same surgical procedure for all patients. According to the different distal locking technique used, all patients were divided into two groups. The standard fluoroscopic freehand technique was used for Group FH, while the electromagnetic real‐time targeting technique was used for Group EM. All procedures were performed by two senior surgeons. Overall surgical time, cases of complications, failure of distal locking, union time, and shoulder function assessment were recorded intraoperatively and during follow‐up. Results Twenty‐seven patients in Group FH and 33 patients in Group EM met the inclusion criteria. No significant difference was found in the demographic data of the two groups. The mean surgical time was 76.48 ± 10.73 min in Group FH and 65.61 ± 8.91 min in Group EM (P

Published
2020
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