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11 results on '"Free, Samantha L."'

2. Role of SOX2 Mutations in Human Hippocampal Malformations and Epilepsy

Author

Sisodiya, Sanjay M., primary, Ragge, Nicola K., additional, Cavalleri, Gianpiero L., additional, Hever, Ann, additional, Lorenz, Birgit, additional, Schneider, Adele, additional, Williamson, Kathleen A., additional, Stevens, John M., additional, Free, Samantha L., additional, Thompson, Pamela J., additional, van Heyningen, Veronica, additional, and FitzPatrick, David R., additional

Published
2006
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3. A novel homeobox mutation in the PITX2 gene in a family with Axenfeld‐Rieger syndrome associated with brain, ocular, and dental phenotypes

Author

Idrees, Faisal, primary, Bloch‐Zupan, Agnes, additional, Free, Samantha L., additional, Vaideanu, Daniela, additional, Thompson, Pamela J., additional, Ashley, Paul, additional, Brice, Glen, additional, Rutland, Paul, additional, Bitner‐Glindzicz, Maria, additional, Khaw, Peng T., additional, Fraser, Scott, additional, Sisodiya, Sanjay M., additional, and Sowden, Jane C., additional

Published
2006
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6. SOX2 anophthalmia syndrome

Author

Ragge, Nicola K., primary, Lorenz, Birgit, additional, Schneider, Adele, additional, Bushby, Kate, additional, de Sanctis, Luisa, additional, de Sanctis, Ugo, additional, Salt, Alison, additional, Collin, J. Richard O., additional, Vivian, Anthony J., additional, Free, Samantha L., additional, Thompson, Pamela, additional, Williamson, Kathleen A., additional, Sisodiya, Sanjay M., additional, van Heyningen, Veronica, additional, and FitzPatrick, David R., additional

Published
2005
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9. Polymicrogyria and absence of pineal gland due to PAX6 mutation

Author

Mitchell, Tejal N., primary, Free, Samantha L., additional, Williamson, Kathleen A., additional, Stevens, John M., additional, Churchill, Amanda J., additional, Hanson, Isabel M., additional, Shorvon, Simon D., additional, Moore, Anthony T., additional, van Heyningen, Veronica, additional, and Sisodiya, Sanjay M., additional

Published
2003
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11. Statistical neuroanatomy of the human inferior frontal gyrus and probabilistic atlas in a standard stereotaxic space.

Author

Hammers A, Chen CH, Lemieux L, Allom R, Vossos S, Free SL, Myers R, Brooks DJ, Duncan JS, and Koepp MJ

Subjects
Adult, Algorithms, Brain Mapping instrumentation, Female, Humans, Image Processing, Computer-Assisted methods, Image Processing, Computer-Assisted statistics & numerical data, Magnetic Resonance Imaging statistics & numerical data, Male, Middle Aged, Neuroanatomy instrumentation, Neuroanatomy methods, Observer Variation, Sex Characteristics, Stereotaxic Techniques, Brain Mapping methods, Frontal Lobe anatomy & histology, Magnetic Resonance Imaging methods, Models, Neurological, Probability
Abstract

We manually defined the inferior frontal gyrus (IFG) on high-resolution MRIs in native space in 30 healthy subjects (15 female, median age 31 years; 15 male, median age 30 years), resulting in 30 individual atlases. Using standard software (SPM99), these were spatially transformed to a widely used stereotaxic space (MNI/ICBM 152) to create probabilistic maps. In native space, the total IFG volume was on average 5%, and the gray matter (GM) portion 12% larger in women (not significant). Expressed as a percentage of ipsilateral frontal lobe volume (i.e., correcting for brain size), the IFG was an average of 20%, and the GM portion of the IFG 27%, larger in women (P < 0.005). Correcting for total lobar volume yielded the same result. No asymmetry was found in IFG volumes. There were significant positional differences between the right and left IFGs, with the right IFG being further lateral in both native and stereotaxic space. Variability was similar on the left and right, but more pronounced anteriorly and superiorly. We show differences in IFG volume, composition, and position between sexes and between hemispheres. Applications include probabilistic determination of location in group studies, automatic labeling of new scans, and detection of anatomical abnormalities in patients.

Published
2007
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