1. Limitations of Gallium-67 SPECT in histological transformation of chronic lymphocytic leukaemia: an analysis of 13 patients with clinically suspected Richter's syndrome
- Author
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Laura Rosiñol, Jordi Esteve, Francesc Cobo, Francesc Bosch, F. Martín, Marta Gómez, Antonio Fernández Martínez, Elias Campo, Emili Montserrat, Francisco Javier Setoain, and E. Nadal
- Subjects
Male ,Pathology ,medicine.medical_specialty ,Proliferative index ,Chronic lymphocytic leukemia ,Gallium Radioisotopes ,Sensitivity and Specificity ,medicine ,Humans ,Ki67 antigen ,Aged ,Aged, 80 and over ,Tomography, Emission-Computed, Single-Photon ,S syndrome ,Lymphocytic leukaemia ,business.industry ,Large-cell lymphoma ,Hematology ,Middle Aged ,medicine.disease ,Leukemia, Lymphocytic, Chronic, B-Cell ,Lymphoma ,Female ,Lymphoma, Large B-Cell, Diffuse ,Complication ,business - Abstract
Gallium-67 single photon emission computerized tomography (Ga-67 SPECT) was performed in 13 chronic lymphocytic leukaemia (CLL) patients suspected of evolution into diffuse large B-cell lymphoma (DLCL) or Richter's syndrome (RS). Six positive and nine negative Ga-67 SPECTs were observed. Ten patients were biopsied (five in each group). DLCL was not detected in any Ga-67-positive patient, including those in whom Ga-67-positive areas were biopsied. The only case of DLCL was demonstrated in a Ga-67-negative patient. The tumoral proliferative index (Ki67 antigen expression) was moderate and similar in both groups of patients. These results illustrate the limitations of Ga-67 SPECT in identifying RS.
- Published
- 2002
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