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Your search keyword '"Fletcher, Courtney V"' showing total 21 results
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21 results on '"Fletcher, Courtney V"'

1. Establishment of a Four‐Cell In Vitro Blood‐Brain Barrier Model With Human Primary Brain Cells

Author

Malik, Johid R., primary, Modebelu, Ukamaka O., additional, Fletcher, Courtney V., additional, Podany, Anthony T., additional, Scarsi, Kimberly K., additional, Byrareddy, Siddappa N., additional, Anand, Robbyn K., additional, Buch, Shilpa, additional, Sil, Susmia, additional, Le, Jennifer, additional, Bradley, John S., additional, Brown, Ashley N., additional, Sutar, Debapriya, additional, and Avedissian, Sean N., additional

Published
2024
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3. Comparative Pharmacokinetics of Tixagevimab/Cilgavimab ( AZD7442 ) Administered Intravenously Versus Intramuscularly in Symptomatic SARS‐CoV ‐2 Infection

Author

Bender Ignacio, Rachel A., primary, Wohl, David A., additional, Arends, Rosalin, additional, Pilla Reddy, Venkatesh, additional, Mu, Ying, additional, Javan, Arzhang Cyrus, additional, Hughes, Michael D., additional, Eron, Joseph J., additional, Currier, Judith S., additional, Smith, Davey, additional, Chew, Kara W., additional, Gibbs, Michael, additional, and Fletcher, Courtney V., additional

Published
2022
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7. Real‐Time and Wireless Assessment of Adherence to Antiretroviral Therapy With Co‐Encapsulated Ingestion Sensor in HIV ‐Infected Patients: A Pilot Study

Author

Daar, Eric S., primary, Rosen, Marc I., additional, Wang, Yan, additional, Siqueiros, Lisa, additional, Shen, Jie, additional, Guerrero, Mario, additional, Xiong, Di, additional, Dao, John, additional, Young, Todd, additional, Corado, Katya, additional, Fletcher, Courtney V., additional, and Liu, Honghu, additional

Published
2019
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17. Concentration-controlled zidovudine therapy*

Author

Fletcher, Courtney V., primary, Acosta, Edward P., additional, Henry, Keith, additional, Page, Linda M., additional, Gross, Cynthia R., additional, Kawle, Sagar P., additional, Remmel, Rory P., additional, Erice, Alejo, additional, and Balfour, Henry H., additional

Published
1998
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21. CD4 response is correlated with peak plasma concentrations of indinavir in adults with undetectable human immunodeficiency virus ribonucleic acid.

Author

Anderson PL, Brundage RC, Kakuda TN, and Fletcher CV

Subjects
Adult, CD4 Lymphocyte Count, Clinical Trials as Topic statistics & numerical data, Female, HIV genetics, HIV immunology, HIV Infections blood, HIV Infections drug therapy, HIV Protease Inhibitors blood, HIV Protease Inhibitors therapeutic use, Humans, Indinavir therapeutic use, Male, Middle Aged, Regression Analysis, Retrospective Studies, Statistics, Nonparametric, CD4-Positive T-Lymphocytes metabolism, HIV drug effects, HIV Infections immunology, Indinavir blood, RNA, Viral blood
Abstract

We retrospectively evaluated correlates of increases in CD4 cell count in antiretroviral agent-naive subjects with fewer than 50 copies per milliliter of plasma human immunodeficiency virus ribonucleic acid who were participating in a study of indinavir, lamivudine, and zidovudine therapy. Pharmacologic data from intensive pharmacokinetic studies and baseline patient characteristics were evaluated as predictors of the increase in CD4 count from baseline to weeks 24, 56, and 80. Relations were investigated with regression analysis. Of all covariates, maximum plasma concentration (C(max)) of indinavir was significantly and uniquely associated with increases in CD4 count from baseline to all end points (P =.002 at week 80; n = 20). At week 80, subjects with a C(max) greater than the overall group median value of 7 microg/ml had an increase in CD4 count of 358 cells/microl versus 197 cells/microl for those with a C(max) less than 7 microg/ml (P =.006). These data suggest distinct pharmacodynamic relations exist for immune reconstitution and suppression of plasma human immunodeficiency virus ribonucleic acid. We hypothesize this new finding may be associated with expression of P-glycoprotein.

Published
2002
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