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37 results on '"Fink-Gremmels, J"'

5. Workshop report: The 2012 Antimicrobial Agents in Veterinary Medicine: exploring the consequences of antimicrobial drug use: a 3-D approach

Author

Martinez, M., primary, Blondeau, J., additional, Cerniglia, C. E., additional, Fink-Gremmels, J., additional, Guenther, S., additional, Hunter, R. P., additional, Li, X.-Z., additional, Papich, M., additional, Silley, P., additional, Soback, S., additional, Toutain, P.-L., additional, and Zhang, Q., additional

Published
2014
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35. Risk assessment of contaminants in food and feed

Author

Alexander J, Benford D, Boobis A, Eskola M, Fink-Gremmels J, Fürst P, Heppner C, Schlatter J, and van Leeuwen R

Subjects
CONTAM Panel, risk assessment, contaminants, human health, animal health, Nutrition. Foods and food supply, TX341-641, Chemical technology, TP1-1185
Abstract

The EFSA Panel on Contaminants in the Food Chain (CONTAM Panel) carries out risk assessment on contaminants in food and feed. The presence of hazardous chemical contaminants or undesirable substances in food and feed is often unavoidable as these substances may occur ubiquitously or are of natural origin. Therefore, human and animal exposure to such substances is also unavoidable. The task of the CONTAM Panel is to assess whether or not exposure to a chemical contaminant in food is likely to be associated with adverse health effects in the European population. Similarly, the Panel assesses if the exposure to a contaminant in feed is likely to be associated with adverse health effects in farm animals, fish and pets in Europe, or to represent a risk to the consumer of foods of animal origin. In contrast to EFSA Panels dealing with regulated substances where inter alia applications are taken into account, the CONTAM Panel relies on scientific information that is in the public domain. EFSA often launches calls for data on occurrence of contaminants in food and feedstuffs where Member States and other interested stakeholders are invited to submit data. Whenever possible and required the CONTAM Panel establishes for a substance a health-based guidance value such as tolerable daily intake. For substances that are both genotoxic and carcinogenic, or for which the data are inadequate to establish a health-based guidance value, the margin of exposure approach is used. Recently the CONTAM Panel also used the threshold of toxicological concern approach. In addition, the CONTAM Panel considers inherent uncertainties in relation to objectives, exposure and hazard characterisation in its risk assessments. During 2003-2012, the CONTAM Panel published 107 scientific outputs (55 on food, 43 on feed, 9 on food and feed).

Published
2012
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36. Effects of long-term in vitro exposure of ejaculated boar sperm to zearalenone and α-zearalenol in sperm liquid storage medium.

Author

Sambuu R, Takagi M, Namula Z, Nii M, Taniguchi M, Uno S, Kokushi E, Tshering C, dos Santos RR, Fink-Gremmels J, and Otoi T

Subjects
Animals, Cells, Cultured, Dose-Response Relationship, Drug, Fertilization drug effects, Male, Sperm Motility drug effects, Temperature, Time Factors, Zeranol adverse effects, Culture Media adverse effects, Estrogens, Non-Steroidal adverse effects, Fertilization in Vitro, Spermatozoa drug effects, Spermatozoa physiology, Swine physiology, Zearalenone adverse effects, Zeranol analogs & derivatives
Abstract

The effects of in vitro exposure of porcine spermatozoa to zearalenone (ZEN) and α-zearalenol (α-ZOL) were studied by evaluating several parameters of an in vitro fertilization (IVF) system. For this purpose, boar spermatozoa cultured with semen storage medium containing 0 (control), 10 and 1000 µg/L of ZEN and α-ZOL for 1 week at 5°C were used for IVF of in vitro matured oocytes. Overall, there were no significant differences in the rates of total penetration, monospermic fertilization, and polyspermic fertilization of oocytes inseminated with spermatozoa from the different groups. Similarly, ZEN and α-ZOL at 10 and 1000 µg/L did not have detrimental effects on the cleavage and development to blastocysts of oocytes after in vitro fertilization. Although the motility, viability, and plasma membrane integrity of spermatozoa significantly decreased after 3 weeks of storage compared to non-stored spermatozoa (P < 0.05), ZEN and α-ZOL at the evaluated concentrations did not exert detrimental effects on the above parameters, even after 3 weeks of storage. These results indicate that prolonged exposure of boar spermatozoa to ZEN and α-ZOL up to 1000 µg/L under reduced metabolic conditions does not affect their in vitro function., (© 2012 Japanese Society of Animal Science.)

Published
2013
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37. Endotoxaemia: a review with implications for the horse.

Author

Werners AH, Bull S, and Fink-Gremmels J

Subjects
Animals, Endotoxemia etiology, Endotoxemia prevention & control, Endotoxemia therapy, Endotoxins administration & dosage, Horse Diseases prevention & control, Horse Diseases therapy, Horses, Lipopolysaccharides toxicity, Polymorphism, Genetic, Signal Transduction, Species Specificity, Endotoxemia veterinary, Horse Diseases etiology, Lipopolysaccharides metabolism
Published
2005
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