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Abstract Introduction The Davos Assessment of Cognitive Biases Scale (DACOBS) is widely used to assess cognitive biases in patients who have schizophrenia. However, the lack of a modified Chinese‐language version of the DACOBS (MCL‐DACOBS) precludes Chinese schizophrenic patients from treatment aimed at normalizing cognitive biases, impacting their prognosis. Here, we aimed to produce a DACOBS for China and test the validity and reliability of the resultant MCL‐DACOBS. Methods Eighteen researchers collaborated to develop the MCL‐DACOBS: A total of 15 researchers modified and translated the English version of the DACOBS, 1 native‐English‐speaking researcher back‐translated the scale, and 2 Chinese sinologists localized and optimized the language of the MCL‐DACOBS. Forty‐two volunteers checked the scale items’ comprehensibility, and the two sinologists performed further localization and optimization based on their feedback. The final version of the MCL‐DACOBS used in this study was thus derived from the harmonized English‐language version of the scale. Confirmatory factor analyses (CFAs) were used to examine the best latent structure of the MCL‐DACOBS. Cronbach's α and intraclass correlation coefficients (ICCs) were used to check the reliability. The discriminative ability of the MCL‐DACOBS was assessed according to the area under the receiver operating characteristic curve. Results The CFA showed that all items loaded onto factors with loadings >0.400. A two‐factor structure showed a good model fit (root mean square error of approximation = .018, Tucker–Lewis index = .978, comparative fit index = .984). Promax rotation demonstrated that each item had a high factor load (0.432–0.774). Cronbach's α coefficient and ICC for the MCL‐DOCABS were .965 and .957, respectively, indicating that the scale has ideal reliability. Conclusion The MCL‐DACOBS has good validity and good reliability, and its psychometric properties indicate that it is a valid tool for measuring cognitive biases in Chinese patients with schizophrenia.

Abstract Based on the modular topology and the traditional voltage‐sourced converter (VSC) model, this paper presents an isolated modular multi‐level AC/AC converter with high‐frequency (HF) link and pulse flip circuit for fractional frequency transmission system (FFTS) application. The proposed converter uses the HF transformer to realize electrical isolation, omitting the industrial frequency (IF) transformer with large volume and heavy weight. In the primary side of the HF transformer, the power transmission is realized by the rectifier and the inverter. In the secondary side of the HF transformer, the double H‐bridges are used to realize the natural freewheeling of the leakage current, which solves the problem of voltage overshoot. On the basis of carrier phase‐shifted pulse width modulation (CPS‐PWM), an improved modulation strategy is proposed to realize the HF output voltage of the inverter. It has the advantages of easy expansion, no circulation current, good output voltage quality, low cost and no need of offshore converter station, so it has great potential in the field of offshore wind power grid connection. The working principle, natural freewheeling modes, modulation method and overall system control scheme of the proposed topology are introduced in detail, and the feasibility of the proposed topology is verified by simulation in MATLAB/Simulink environment and test through APPSIM platform.

Abstract Based on a practical long‐distance large‐capacity transmission engineering case, the small‐signal stability of fractional frequency transmission system (FFTS) with Y‐connected modular multi‐level converter (Y‐MMC) is mainly researched in this paper. Different from the previous control strategies of Y‐MMC, this paper establishes a frequency decoupling mathematical model and proposes the decoupling control strategies. Then, the small‐signal model of the Y‐MMC system is obtained. Considering the existence of phase locked loop (PLL) will deteriorate the stability of the system under weak grid, this paper applies the short‐circuit ratio (SCR) for analysis and proposed a new structure of PLL, called phase‐shifted PLL (PS‐PLL), to improve the small‐signal stability of the system. In addition, for better stability and dynamic response performance of the closed‐loop control system, this paper proposes a new parameter optimization objective function for parameters adjustment. Controller parameters optimization is conducted by using the particle swarm optimization (PSO) algorithm and stability evaluation of the system is conducted based on the eigenvalue distribution. Finally, the feasibility and superiority of the proposed strategies and optimization are verified in MATLAB/ Simulink.

Abstract Fractional frequency transmission is a promising solution to offshore wind power integration. This paper proposes a new grid integration scheme of fractional frequency offshore wind power system (FFOWPS) based on Y‐connected modular multilevel converter (Y‐MMC). To get better power quality, a novel Y‐MMC modelling and control method considering frequency leakage is presented. Besides, in order to achieve satisfactory fault ride‐through (FRT) performance for FFOWPS, this paper proposes a novel FRT strategy. The strategy makes use of the onshore grid voltage and offshore grid frequency droop control to coordinately control the power of Y‐MMC and wind turbines. This strategy achieves power balance on both sides of Y‐MMC through coordinated control, thereby suppressing the increase of DC capacitor voltage during faults. It is also able to support the grid by injecting reactive power during voltage sags. Additionally, a new pitch angle control algorithm is designed to keep the balance between input mechanical power and output active power of wind turbines during FRT, avoiding the rapid rise of rotor speed. The simulation results in MATLAB/Simulink demonstrate good performance of FFOWPS during wind speed variations and validate the effectiveness of the proposed frequency leakage suppression strategy and FRT strategy.

Abstract Enlarging the speed range of wind turbines is an effective way to increase power production in low‐frequency band wind which contains more energy and is very challenging for DFIG‐based wind energy conversion system (WECS). The analysis shows that current controllability of the converter is the main factor limiting bidirectional speed range extension (BSRE). This problem can be solved by increasing dc‐bus voltage, but a constant and high dc‐bus voltage will increase the electrical stress and switching losses of the converter. This paper proposed a dynamic minimum dc‐bus voltage (DMDCV) technique in which the dc‐bus voltage can automatically adjust to enable the back‐to‐back voltage source converter to work in linear modulation mode at its minimum value, thus supporting BSRE while also achieving multiple goals including low electrical stress and low switching losses. Two implementation methods of DMDCV with and without modulation depth loop are proposed and discussed. The co‐simulation results verified the feasibility of DMDCV and the advantages of BSRE in improving power generation.

Abstract Introduction While the psychiatric benefits of ketamine have been verified through clinical trials, there is limited information about ketamine augmentation in patients with treatment‐resistant bipolar depression (TRBPD). Hence, in the present study, we investigate the therapeutic efficacy and functional brain alterations associated with multi‐infusion ketamine augmentation in patients with TRBPD. Methods The present three‐week study included 38 patients with TRBPD, all of whom received a series of nine ketamine injections over the study period. The Hamilton Depression Rating Scale (HAMD) was used to assess the effects of multi‐infusion ketamine combined with mood stabilizers. Brain function was evaluated by global functional connectivity density (gFCD). Results Adjunctive treatment with multiple infusions of ketamine, when combined with a mood stabilizer, could effectively alleviate depressive symptoms for one week, yet the symptoms began to relapse during the second week. Functional brain alterations were detected via gFCD. Specifically, gFCD reductions were mainly found in the bilateral insula, right caudate nucleus, and bilateral inferior frontal gyrus, while increased gFCD was mainly located in the bilateral postcentral gyrus, subgenual anterior cingulate cortex, bilateral thalamus, and cerebellum. Although gFCD alterations were sustained for up to three weeks after the first ketamine infusion, the antidepressant effects of ketamine augmentation sharply declined from the end of the second week of treatment. Conclusions Multi‐infusion ketamine augmentation can rapidly alleviate depressive symptoms in patients with TRBPD. The clinical effects were primarily visible in the first week after treatment and partially sustained for two weeks; however, the therapeutic effects and related functional brain alterations sharply decreased from the end of the second week. Based on these findings, we demonstrated that the clinical efficacy and functional brain alterations induced by ketamine augmentation are transient.

ABSTRACT Background Despite numerous studies confirming the association between insulin resistance (IR) and macrophage polarization, there is a lack of bibliometric analysis in this area. Therefore, our objective is to conduct a comprehensive analysis of published literature and identify potential future research trends using bibliometrics. Method Publications on the topic of macrophage polarization in IR were gathered from the Web of Science Core Collection database (WoSCC) spanning the years 1999–2023. Bibliometric analysis and visualization were conducted using VOSviewers, CiteSpace, the R package “bibliometrix” and Tableau Public. Result A total of 3435 articles published between 1999 and 2023 were included in the analysis. These articles originated from 75 countries, with the United States and China leading in contributions. The top five research institutions are the University of California, San Diego, Harvard University, the University of Michigan, Shanghai Jiao Tong University, and Huazhong University of Science and Technology. In this research domain, Diabetes is the most frequently published journal, and the Journal of Clinical Investigation is the most co‐cited. Among the 19,398 authors contributing to these publications, Lumeng CN. not only authored the most papers but also received the highest number of co‐citations. “Insulin resistance” emerges as a primary keyword in the analysis of emerging research hotspots. Conclusion For the first time, bibliometric methods have been employed to conduct a comprehensive summary of papers relevant to macrophage polarization in IR. This study aims to identify the current research direction and future research hotspots, offering valuable guidance and insights for scholars in the field.

Abstract Background Despite the recognized therapeutic potential of programmed cell death protein 1/programmed death‐ligand 1 (PD‐1/PD‐L1) inhibitors in advanced esophageal squamous cell carcinoma (ESCC), their role in neoadjuvant therapy and reliable efficacy biomarkers remain elusive. Materials and Methods We retrospectively analyzed locally advanced ESCC patients who underwent surgery following a 2‐cycle platinum and paclitaxel‐based treatment, with or without PD‐1 inhibitors (January 2020–March 2023). We assessed peripheral blood indexes and tertiary lymphoid structures (TLS) density to evaluate their impact on pathological response and prognosis, leading to a clinical prediction model for treatment efficacy and survival. Results Of the 157 patients recruited, 106 received immunochemotherapy (ICT) and 51 received chemotherapy (CT) alone. The ICT group demonstrated a superior pathological response rate (PRR) (47.2% vs. 29.4%, p = 0.034) with comparable adverse events and postoperative complications. The ICT group also showed a median disease‐free survival (DFS) of 39.8 months, unattained by the CT group. The 1‐year DFS and overall survival (OS) rates were 73% and 91% for the ICT group, and 68% and 81% for the CT group, respectively. We found higher baseline activated T cells, lower baseline Treg cells, and a decreased posttreatment total lymphocyte and CD4+/CD8+ ratio predicted an enhanced PRR. Reduced posttreatment CD4+/CD8+ ratio and increased NK cells were associated with prolonged survival, while higher TLS density indicated poorer prognosis. Among ICT group, a lower posttreatment CD4+/CD8+ ratio indicated longer DFS and reduced posttreatment B cells indicated longer OS. A nomogram integrating these predictors was developed to forecast treatment efficacy and survival. Conclusion The combination of PD‐1 inhibitors and chemotherapy appears promising for locally advanced ESCC. Evaluating the differentiation status and dynamic changes of peripheral blood immune cells may provide valuable predictive insights into treatment efficacy and prognosis.

ABSTRACT Introduction Liver fibrosis is primarily driven by the activation of hepatic stellate cells (HSCs), which involves various epigenetic modifications. Objectives N6‐methyladenosine (m6A), the most prevalent RNA modification in eukaryotic cells, influences numerous physiological and pathological processes. Nevertheless, the role of insulin‐like growth factor 2 mRNA‐binding protein 3 (IGF2BP3), a reader gene mediating m6A modifications, in liver fibrosis remains unclear. Methods and results This study demonstrated that IGF2BP3 knockout reduces liver fibrosis by promoting HSC ferroptosis (FPT) and inactivating HSCs. Multi‐omics analysis revealed that HSC‐specific IGF2BP3 knockout decreased m6A content in Jagged1 (Jag1), a key component of the Notch signalling pathway. Furthermore, IGF2BP3 deficiency significantly reduced the expression of hairy and enhancer of split‐1 (Hes1), a transcription factor in the Notch/Jag1 signalling pathway, with mRNA levels declining to 35%–62% and protein levels to 28%–35%. Additionally, it suppressed glutathione peroxidase 4 (GPX4) (decreased to approximately 31%–38%), a negative regulator of FPT, thereby facilitating HSC FPT progression and reducing profibrotic gene expression. Conclusion These findings uncover a novel IGF2BP3/Notch/Jag1 signalling pathway involving HSC FPT, suggesting promising targets for ameliorating liver fibrosis. Key Points/Highlights IGF2BP3 deficiency inactivates Jag1 signalling. IGF2BP3 deficiency‐mediated m6A modifications promote HSC ferroptosis. IGF2BP3 inhibition facilitates ferroptosis in HSCs via the Hes1/GPX4 axis. IGF2BP3 deficiency inactivates Jag1/Notch1/3/Hes1 signalling pathway inactivation, leading to the decrease in GPX4, which contributes to HSC ferroptosis.

Abstract Fiber‐based artificial muscles are promising for smart textiles capable of sensing, interacting, and adapting to environmental stimuli. However, the application of current artificial muscle‐based textiles in wearable and engineering fields has largely remained a constraint due to the limited deformation, restrictive stimulation, and uncomfortable. Here, dual‐responsive yarn muscles with high contractile actuation force are fabricated by incorporating a very small fraction (