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Your search keyword '"Faure, Christophe"' showing total 14 results
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14 results on '"Faure, Christophe"'

9. P0744 A WERMER SYNDROM IN A 7 YEARS OLD CHILD.

Author

Bellaiche, Marc M., primary, Marti, Lucian L., additional, Ajzenman, Catherine C., additional, Mougenot, Jean Françoisy J. F., additional, Faure, Christophe C., additional, Aigrain, Yves Y., additional, and Cezard, Jean Pierre J. P., additional

Published
2004
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13. Intestinal Transplantation in Children: Preliminary Experience in Paris

Author

Goulet, Olivier, primary, Jan, Dominique, additional, Lacaille, Florence, additional, Colomb, Virginie, additional, Michel, Jean-Luc, additional, Damotte, Diane, additional, Jouvet, Philippe, additional, Brousse, Nicole, additional, Faure, Christophe, additional, Cézard, Jean-Pierre, additional, Sarnacki, Sabine, additional, Peuchmaur, Michel, additional, Hubert, Philippe, additional, Ricour, Claude, additional, and Révillon, Yann, additional

Published
1999
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14. Gangliogenesis in the enteric nervous system: roles of the polysialylation of the neural cell adhesion molecule and its regulation by bone morphogenetic protein-4.

Author

Faure C, Chalazonitis A, Rhéaume C, Bouchard G, Sampathkumar SG, Yarema KJ, and Gershon MD

Subjects
Animals, Bone Morphogenetic Protein 4, Cell Differentiation, Enteric Nervous System cytology, Ganglia, Autonomic embryology, Ganglia, Autonomic growth & development, Ganglia, Autonomic metabolism, Gene Expression Regulation, Developmental, Neural Cell Adhesion Molecule L1 genetics, Neural Cell Adhesion Molecule L1 metabolism, Neural Crest metabolism, Neurons metabolism, Rats, Rats, Sprague-Dawley, Sialic Acids genetics, Sialyltransferases genetics, Sialyltransferases metabolism, Signal Transduction, Bone Morphogenetic Proteins pharmacology, Cell Adhesion Molecules, Neuronal metabolism, Enteric Nervous System embryology, Enteric Nervous System growth & development, Sialic Acids metabolism
Abstract

The neural crest-derived cells that colonize the fetal bowel become patterned into two ganglionated plexuses. The hypothesis that bone morphogenetic proteins (BMPs) promote ganglionation by regulating neural cell adhesion molecule (NCAM) polysialylation was tested. Transcripts encoding the sialyltransferases, ST8Sia IV (PST) and ST8Sia II (STX), which polysialylate NCAM, were detectable in fetal rat gut by E12 but were downregulated postnatally. PSA-NCAM-immunoreactive neuron numbers, but not those of NCAM, were developmentally regulated similarly. Circular smooth muscle was transiently (E16-20) PSA-NCAM-immunoreactive when it is traversed by migrating precursors of submucosal neurons. Neurons developing in vitro from crest-derived cells immunoselected at E12 with antibodies to p75(NTR) expressed NCAM and PSA-NCAM. BMP-4 promoted neuronal NCAM polysialylation and clustering. N-butanoylmannosamine, which blocks NCAM polysialylation, but not N-propanoylmannosamine, which does not, interfered with BMP-4-induced neuronal clustering. Observations suggest that BMP signaling enhances NCAM polysialylation, which allows precursors to migrate and form ganglionic aggregates during the remodeling of the developing ENS.

Published
2007
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