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2. Cover Image, Volume 140, Issue 48

Author

Jiang, Linxu, primary, Zhang, Wenxin, additional, Fang, Ke, additional, Wang, Honglong, additional, Wang, Xiaoguang, additional, Su, Xiaoya, additional, and Xia, Faming, additional

Published
2023
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12. Ferrous hemoglobin and hemoglobin‐based oxygen carriers acting as a peroxidase can inhibit oxidative damage to endothelial cells caused by hydrogen peroxide

Author

Huo, Shuangshuang, primary, Lei, Xiaofeng, additional, He, Dan, additional, Zhang, Hua, additional, Yang, Zhipeng, additional, Mu, Wenhua, additional, Fang, Ke, additional, Xue, Dan, additional, Li, He, additional, Li, Xiaoyan, additional, Jia, Nan, additional, Zhu, Hongli, additional, Chen, Chao, additional, and Yan, Kunping, additional

Published
2021
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15. Convolutional neural network for accelerating the computation of the extended Tofts model in dynamic contrast‐enhanced magnetic resonance imaging

Author

Fang, Ke, primary, Wang, Zejun, additional, Li, Zhaoqing, additional, Wang, Bao, additional, Han, Guangxu, additional, Cheng, Zhaowei, additional, Chen, Zhihong, additional, Lan, Chuanjin, additional, Zhang, Yi, additional, Zhao, Peng, additional, Jin, Xinyu, additional, Liu, Yingchao, additional, and Bai, Ruiliang, additional

Published
2020
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17. Celastrol alleviates metabolic disturbance in high‐fat diet‐induced obese mice through increasing energy expenditure by ameliorating metabolic inflammation

Author

Yang, Xueping, primary, Wu, Fan, additional, Li, Lingli, additional, Lynch, Ernest C., additional, Xie, Linglin, additional, Zhao, Yan, additional, Fang, Ke, additional, Li, Jingbin, additional, Luo, Jinlong, additional, Xu, Lijun, additional, Zou, Xin, additional, Lu, Fuer, additional, and Chen, Guang, additional

Published
2020
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19. The miR393a/target module regulates seed germination and seedling establishment under submergence in rice (Oryza sativaL.)

Author

Yakun Xie, Yinong Yang, Fang Ke, Hongwu Bian, Muyuan Zhu, Ning Han, Fu Guo, and Junhui Wang

Subjects
0106 biological sciences, 0301 basic medicine, chemistry.chemical_classification, Oryza sativa, biology, Physiology, fungi, food and beverages, Plant Science, biology.organism_classification, Oryza, 01 natural sciences, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, Coleoptile, chemistry, Germination, Seedling, Auxin, Botany, Radicle, Abscisic acid, 010606 plant biology & botany
Abstract

The conserved miRNA393 family is thought to be involved in root elongation, leaf development and stress responses, but its role during seed germination and seedling establishment remains unclear. In this study, expression of the MIR393a/target module and its role in germinating rice (Oryza sativa L.) seeds were investigated. β-Glucuronidase (GUS) analysis showed that MIR393a and OsTIR1 had spatial-temporal transcriptional activities in radicle roots, coleoptile tips and stomata cells, corresponding to a dynamic auxin response. miR393a promoted primary root elongation when rice seeds were germinated in air and inhibited coleoptile elongation and stomatal development when seeds were submerged. Under submergence, the expression of miR393a was inhibited, and then the auxin response was induced. In the process, OsTIR1 and OsAFB2, auxin receptor genes, were negatively regulated by miR393. We found that miR393a inhibited stomatal development and coleoptile elongation but promoted free indole acetic acid (IAA) accumulation in the rice coleoptile tips. In addition, exogenous abscisic acid (ABA) enhanced the expression of miR393 and inhibited coleoptile growth. Together, miR393a/target plays a role in coleoptile elongation and stomatal development via modulation of auxin signalling during seed germination and seedling establishment under submergence. This study provides new perspectives on the direct sowing of rice seeds in flooded paddy fields.

Published
2016

27. CHA2DS2‐VASc scores predict major adverse cardiovascular events in patients with chronic obstructive pulmonary disease

Author

Ooi, Hean, primary, Chen, Li‐Hsiou, additional, Ni, Yung‐Lun, additional, Shen, Huan‐Ting, additional, Lee, Yen‐Hsien, additional, Chu, Yi‐Chun, additional, Fang, Ke‐Chih, additional, Chen, I‐Hung, additional, Hsu, Shu‐Lan, additional, Chen, Hsing‐Chun, additional, Huang, Chien‐Hsiu, additional, Fan, Kuo‐Sheng, additional, Lai, Chun‐Liang, additional, and Hang, Liang‐Wen, additional

Published
2017
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31. ChemInform Abstract: Synthesis of Disulfides and Diselenides by Copper-Catalyzed Coupling Reactions in Water

Author

Haifeng Xiang, Zhengkai Li, Xiangge Zhou, Hang Deng, Hualong Xu, and Fang Ke

Subjects
inorganic chemicals, chemistry.chemical_compound, chemistry, Aryl, Copper catalyzed, food and beverages, chemistry.chemical_element, Halide, General Medicine, Combinatorial chemistry, Sulfur, Selenium, Coupling reaction
Abstract

A simple and efficient protocol for copper-catalyzed coupling reactions between aryl halides and elemental sulfur or selenium has been developed. A variety of disulfides and diselenides can be obtained in moderate to excellent yields up to 96%.

Published
2013

32. ChemInform Abstract: Cu-Catalyzed Three-Component Synthesis of Substituted Benzothiazoles in Water

Author

Hang Deng, Zhengkai Li, Xiangge Zhou, and Fang Ke

Subjects
chemistry, Component (thermodynamics), chemistry.chemical_element, Organic chemistry, General Medicine, Sulfur, Catalysis
Abstract

In the presence of an optimized catalyst system, the reaction of iodoanilines, aromatic, heteroaromatic or aliphatic aldehydes, and an excess of sulfur affords the corresponding 2-substituted benzothiazoles.

Published
2012

33. ChemInform Abstract: Synthesis of 3-Indole Derivatives by Copper Sulfonato Salen Catalyzed Three-Component Reactions in Water

Author

Xiangge Zhou, Zhengkai Li, Yanyang Qu, Li Zhou, Fang Ke, Di Wu, and Haifeng Xiang

Subjects
chemistry.chemical_classification, Indole test, chemistry.chemical_compound, chemistry, Component (thermodynamics), chemistry.chemical_element, General Medicine, Aldehyde, Medicinal chemistry, Copper, Catalysis, Malononitrile
Abstract

An efficient three-component reaction of indole, aldehyde, and malononitrile in water catalyzed by a copper(II) sulfonato Salen complex afforded 3-indole derivatives in good to excellent yields up to 97%.

Published
2011

34. ChemInform Abstract: An Efficient Copper-Catalyzed Carbon-Sulfur Bond Formation Protocol in Water

Author

Di Wu, Zhengkai Li, Xiangge Zhou, Fang Ke, Yanyang Qu, and Zhaoqiong Jiang

Subjects
chemistry.chemical_compound, chemistry, Potassium thiocyanate, Aryl, Polymer chemistry, Copper catalyzed, chemistry.chemical_element, General Medicine, Bond formation, Carbon, Sulfur
Abstract

A variety of aryl bromides or iodides is converted to symmetrical diaryl sulfides in the reaction with potassium thiocyanate, generally with higher yields starting from aryl iodides.

Published
2011

35. ChemInform Abstract: Catalytic Hydroalkoxylation of Alkenes by Iron(III) Catalyst

Author

Xiangge Zhou, Fang Ke, Zhengkai Li, and Haifeng Xiang

Subjects
inorganic chemicals, Addition reaction, Chemistry, Organic chemistry, General Medicine, Hydroalkoxylation, Catalysis
Abstract

An efficient method for the Markovnikov-type addition of alcohols to mono-substituted olefins is developed using FeCl3 as an inexpensive catalyst.

Published
2011

41. Celastrol alleviates metabolic disturbance in high-fat diet-induced obese mice through increasing energy expenditure by ameliorating metabolic inflammation.

Author

Yang X, Wu F, Li L, Lynch EC, Xie L, Zhao Y, Fang K, Li J, Luo J, Xu L, Zou X, Lu F, and Chen G

Subjects
Adipose Tissue drug effects, Adipose Tissue physiology, Animals, Anti-Inflammatory Agents pharmacology, Cytokines metabolism, Diet, High-Fat, Dyslipidemias drug therapy, Glucose Intolerance drug therapy, Inflammasomes drug effects, Insulin Resistance, Liver drug effects, Macrophages drug effects, Male, Mice, Mice, Inbred C57BL, Mice, Obese, Obesity drug therapy, Pentacyclic Triterpenes, Thermogenesis drug effects, Weight Gain drug effects, Anti-Obesity Agents pharmacology, Energy Metabolism drug effects, Inflammation drug therapy, Triterpenes pharmacology
Abstract

Celastrol, a natural triterpene, has been shown to treat obesity and its related metabolic disorders. In this study, we first assessed the relationship between the antiobesity effects of celastrol and its antiinflammatory activities. Our results showed that celastrol can reduce weight gain, ameliorate glucose intolerance, insulin resistance, and dyslipidemia without affecting food intake in high-fat diet-induced obese mice. A CLAMS was used to clarify the improvement of metabolic profiles was attribute to increased adipose thermogenesis after celastrol treatment. Further studies found that celastrol decreased the infiltration of macrophage as well as its inflammatory products (IL-1β, IL-18, MCP-1α, and TNF-α) in liver and adipose tissues, which also displayed an obvious inhibition of TLR3/NLRP3 inflammasome molecules. This study demonstrated that celastrol could be a potential drug for treating metabolic disorders, the underlying mechanism is related to ameliorating metabolic inflammation, thus increasing body energy expenditure., (© 2020 John Wiley & Sons, Ltd.)

Published
2021
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