1. Human herpesvirus 8 infection DNA positivity is associated with low insulin secretion: A case-control study in a sub-Saharan African population with diabetes
- Author
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Jean Jacques Noubiap, Mesmin Dehayem, Marcel Azabji-Kenfack, Barbara Atogho-Tiedeu, Jérôme LeGoff, Jean Claude Mbanya, V. Balla, Philippe Boudou, Vicky Kamwa, Gaelle Lemdjo, Jean-François Gautier, Eugene Sobngwi, Eric V. Balti, Jean-Louis Nguewa, Eric Lontchi-Yimagou, Martine Etoa, E. Djahmeni, and Fabienne Foufelle
- Subjects
0301 basic medicine ,medicine.medical_specialty ,education.field_of_study ,medicine.diagnostic_test ,business.industry ,Endocrinology, Diabetes and Metabolism ,Population ,virus diseases ,Type 2 Diabetes Mellitus ,Type 2 diabetes ,medicine.disease ,03 medical and health sciences ,030104 developmental biology ,0302 clinical medicine ,Endocrinology ,Insulin resistance ,Diabetes mellitus ,Internal medicine ,medicine ,Homeostatic model assessment ,030212 general & internal medicine ,Lipid profile ,business ,education ,Body mass index - Abstract
Background Viruses have been considered potential triggers for the development of diabetes. This study assessed insulin secretion and insulin sensitivity in human herpesvirus 8 (HHV8)-infected and uninfected sub-Saharan African people with diabetes. Methods In all, 173 people with non-autoimmune diabetes were enrolled consecutively: 124 with type 2 diabetes mellitus (T2DM) and 49 with ketosis-prone diabetes (KPD) admitted in hyperglycemic crisis. Those with KPD were further subdivided into those with new-onset ketotic-phase KPD (n = 34) or non-ketotic phase KPD (n = 15). All participants were screened for HHV8-specific antibodies and genomic DNA. Blood samples were collected for analysis of fasting glucose, HbA1c, lipid profile, and C-peptide, with insulin resistance and secretion estimated by homeostasis model assessment. Results Among the 173 diabetic participants, 88 (50.9%) were positive for HHV8 antibodies (Ac-HHV8+), including 15 (8.7%) positive for HHV8 DNA (DNA-HHV8+). The seroprevalence of HHV8 was similar between T2DM (55.6%) and KPD (61.2%) subjects. Of those with and without ketotic-phase KPD, 35.3% and 46.7% were Ac-HHV8+, respectively. Body mass index was significantly in lower DNA-HHV8+ than DNA-HHV8- subjects. Low-density lipoprotein and total cholesterol were significantly higher, but C-peptide and homeostatic model assessment of β-cell function (HOMA-β) were significantly lower in DNA-HHV8+ than DNA-HHV8- participants. After excluding DNA-HHV8+ participants, triglyceride concentrations were significantly higher in Ac-HHV8+ (n = 73) than Ac-HHV8- (n = 85) subjects. In contrast, HOMA-β was significantly higher among Ac-HHV8+ than Ac-HHV8- participants. Conclusions In the present study, HHV8 DNA positivity was associated with low insulin secretion in this sub-Saharan African diabetes population.
- Published
- 2018